CSH Asia/ICMS Joint Conference
on Tumor Microenvironment
Suzhou, China
November 13-17, 2012
TUESDAY, NovEMbEr 13, 2012
isaac P. Witz, Tel Aviv University, Tel Aviv, Israel
Introductory Remarks
Introduced by isaac P. Witz
robert C. Gallo, Institute of Human Virology, University of Maryland
School of Medicine, Baltimore, Maryland, USA Human tumor viruses—Old foes and new challenges
Welcome Reception and Dinner
WEDNESDAY, NovEMbEr 14, 2012
iMMUNitY iN tHe tUMOr MiCrOeNVirONMeNt
Chairperson: W. H. Fridman, Cordeliers Research Centre, Paris,
Xuetao Cao, Chinese Academy of Medical Sciences, Beijing, China
Identification of new populations of immunosuppressive cells in
tumor microenvironment
ron N. Apte, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Interleukin-1 as a major cytokine detemining the balance between
inflammation and immunity in the tumor microenvironment
Michael r. Shurin, University of Pittsburgh, Pittsburgh, Pennsylvania,
Environmental regulation of the tumor microenvironment
Wolf H. Fridman, Cordeliers Research Centre, Paris, France
Shaping the immune microenvironment—Soil or seed?
Coffee Break
Introduced by isaac P. Witz
Carlo Croce, Ohio State University, Columbus, Ohio, USA
microRNas can function as ligands for TLR and regulate the
interactions between cancer cells and their microenviroment
reGULAtOrY eVeNtS iN tHe tUMOr MiCrOeNVirONMeNt
Chairperson: Chairperson: X. Cao, Chinese Academy of Medical
Heike Allgayer, University of Heidelberg, Mannheim, Germany
Defining key functions of microRNAs in several processes of the
metastatic cascade
Hidetoshi tahara, Graduate School of Biomedical Sciences Hiroshima
Senescence associated microRNas and exosomes coordinately
regulate cellular senescence and tumor microenvironment
PLENArY SESSIoN 2 continued
reGULAtOrY eVeNtS iN tHe tUMOr MiCrOeNVirONMeNt
eitan Yefenof, Hebrew University, Jerusalem, Israel
Steroid induced death of hemopoietic cancer cells—an interplay
between protein kinases and micro RNas
Baocun Sun, Tianjin Medical University, Tianjin, China
Study on vasculogenic mimicry and its molecular mechanism
Yongzhang Luo, Tsinghua University, Beijing, China
The CXCL12 (SDF-1α)/CXCR4 axis regulates both tumor angiogenesis
and lymphangiogenesis
theresa Guise, Indiana University, Indianapolis, Indiana, USA
muscle dysfunction associated with bone metastases—Role of
ryanodine receptor remodeling
Introduced by: isaac P. Witz
Peter H. Krammer
, German Cancer Research Center (DKFZ),
Regulation of the immune response by Annexin I PoSTEr vIEWING and CHINESE TEA & bEEr TASTING
Full list of posters can be found on page xvii of the program
Chairperson: L. Li,
Nankai University School of Pharmaceutical
Luyuan Li, Nankai University, Tianjin, China
TNFSF15 modulates angiogenesis and inflammation
Adit Ben-Baruch, Tel Aviv University, Tel Aviv, Israel
Regulation of pro-angiogenic switch and cell-remodeling by the
inflammatory microenvironment in breast cancer
Alberto Mantovani, Istituto Clinico Humanitas IRCCS, Milan, Italy
The yin-yang of tumor associated macrophages and cancer-related
Neta erez, Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel
Pro-inflammatory signaling by cancer-associated fibroblasts co-
evolves along defined tumor stages of mammary carcinogenesis
Subhra K. Biswas, A*STAR, Singapore
a protumoral role for myelomonocytic cells in human cancer
progression-a molecular insight
THUrSDAY, NovEMbEr 15, 2012
Visit to Old Suzhou
reGULAtOrY NetWOrKS iN tHe tUMOr
Chairpersons: D. Hoon,
John Wayne Cancer Institute, Santa Monica,
A. thomas-tikhonenko, University of Pennsylvania
Dave S. Hoon, John Wayne Cancer Institute, Santa Monica, California,
B7-H3 cell surface molecule associated with tumor progression and
epigenetic regulatory activity in cutaneous melanoma
Andrei thomas-tikhonenko, Perelman School of Medicine at the
University of Pennsylvania, Philadelphia, Pennsylvania, USA Pro-angiogenic microRNas in colorectal cancer—Lessons from mouse
models and cancer genomics
reuven reich, Institute of Drug Research, Jerusalem, Israel
microRNa-mediated regulation of ovarian carcinoma—Role of
Yaw-Chyn Lim, National University of Singapore, Singapore
Breast cancer cells modulate the tissue microenvironment of distant
sites to facilitate metastasis
Shelly tartakover Matalon, Tel Aviv University, Tel Aviv, Israel; Meir
Dr. Jekyll and mr. Hyde—The placenta’s dual effect on the metastatic
potential of breast cancer cells
eli Breuer, Hebrew University, Jerusalem, Israel
Carbamoylphosphonates control tumor cell proliferation and
dissemination by simultaneously inhibiting carbonic anhydrase IX and
matrix metalloproteinase-2
Ying Wei, University of California San Francisco, San Francisco,
Identification of pY654-β-catenin as a critical co-factor in hypoxia-
inducible factor-1α signaling and tumor responses to hypoxia
Coffee Break
rachel Bar-Shavit, Hadassah-Hebrew University Hospital, Jerusalem,
Emerging tasks of PaR in breast cancer—molecular mechanism and
translational outcome
Linda J. Metheny-Barlow, Wake Forest School of Medicine, Winston-
activation of a BDNF-p75NTR axis in breast cancer brain metastatic
cells by the microenvironment
Abdelilah Aboussekhra, King Faisal Specialist Hospital & Research
Role of p16INK4A and caffeine in suppressing the expression/
secretion of IL-6 and the pro-carcinogenic effects of breast cancer-
associated fibroblasts
Ben-Zion Katz, Tel-Aviv Medical Center, Tel-Aviv, Israel
Divergence in CD19-mediated signaling unfolds intra-clonal diversity
in chronic lymphocytic leukemia which correlates with disease
Xiyun Yan, Institute of Biophysics, Chinese Academy of Sciences,
The role of CD146 in tumor cell migration and tumor angiogenesis
rami Aqeilan, Hebrew University, Jerusalem, Israel
a pleiotropically tumor suppressor WWOX, inhibits breast cancer
Chairperson: A. Ostman,
Karolinska Institutet, Stockholm, Sweden
Arne Östman, Karolinska Institutet, Stockholm, Sweden
Impact of PDgFR-positive CaFs on prognosis, drug response and
Zhihai Qin, Institute of Biophysics, CAS, Beijing, China
Microtubule modification in stromal fibroblasts accelerates
inflammation and tumor progression
Donghui Zou, University of Otago, Dunedin, New Zealand
gene expression differences between colorectal cancer derived CaFs
and colonic fibroblasts illustrate CAF biology
Catherine Muller, IPBS CNRS UMR 5089, Toulouse, France
Adipocyte-derived fibroblasts (ADFs), a newly identified stromal
cell population, promote tumor progression and contribute to
desmoplastic reaction in breast cancer
Cecilia S. Leung, The University of Texas MD Anderson Cancer Center,
Cancer associated fibroblast derived MFAP5 regulates ovarian cancer
cell motility and invasion potential through calcium dependent CREB/
TNNC1 signaling pathways
tao Shan, First Affiliated Hospital of Medical College, Xi’an Jiaotong
Caveolin-1, as a novel biomarker of lethal tumor microenvironment, is inhibited via autophagy in pancreatic cancer associated fibroblasts cells SYMPoSIUM 3
Chairperson: L. Borsig,
University of Zurich, Switzerland
Lubor Borsig, University of Zürich, Zurich, Switzerland
Colon carcinoma extravasation is induced by CCL2-induced signaling
through endothelial CCR2 that is mediated through the JAK2-Stat5
and p38MAPK pathway
Coffee Break
Joseph Kwong, The Chinese University of Hong Kong, Shatin, Hong
Cancer cell-derived lymphotoxin mediates reciprocal tumor-stromal
interactions in ovarian cancer by inducing fibroblast-secreting
Bo Zhu, Xinqiao Hospital Institute of Cancer, Chongqing, China
Cancer stem cells enhance invasion of cancer cells via CCL-5-
mediated epithelial-mesenchymal transition
etta Livneh, Ben Gurion University of the Negev, Beer Sheva, Israel
PKC and its polymorphism enhance secretion of the pro-inflamatory
cytokine IL-6 and are involved in establishing cellular senescence
elena Voronov, Ben Gurion University of the Negev, Beer Sheva, Israel
The effects of IL-1 on colorectal cancer development
Li Yang, National Cancer Institute, Bethesda, Maryland, USA
Tumor microenvironment, the answer for the puzzling dual function
of TgFβ
Marcelo ehrlich, Tel Aviv University, Tel Aviv, Israel
Transport and signaling of the receptors for transforming growth
factor-β (TgF-β)—Regulation by molecular motifs, cellular factors and
the cell cycle
Akira Saito, University of Tokyo, Tokyo, Japan
An integrated expression profiling reveals target genes of TGF-β and
TNF-α possibly mediated by microRNas in lung cancer cells
Visit to Old City of Suzhou and free evening
FrIDAY, NovEMbEr 16, 2012
reGULAtOrY eVeNtS iN tHe tUMOr MiCrOeNVirONMeNt
Chairperson: A. raz,
Wayne State University, Detroit, Michigan, USA
takahiro Ochiya, National Cancer Center, Tokyo, Japan
Exosome as a novel regulator of tumor-microenvironment
Menashe Bar-eli, UT MD Anderson Cancer Center, Houston, Texas, USA
Driving genes in melanoma metastasis—The role of the tumor
Bernd Groner, Georg Speyer Haus, Frankfurt am Main, Germany
Reciprocal interactions between stromal and epithelial cells regulate
the ductal outgrowth during glandular development and the invasive
potential of metastasizing mammary tumor cells
Avraham raz, Wayne State University, School of Medicine, Detroit,
On the role of autocrine motility factor-a tumor secreted cytokine in
cancer progression and metastasis
Coffee Break
raghu Kalluri, Harvard Medical School, Beth Israel Deaconess Medical
Fibrosis and cancer progression
Yu-quan Wei, The State Key Lab of Biotherapy, West China Hospital,
Proteomics analysis of tumor microenvironment—implications of
metabolic and oxidative stresses in tumorigenesis
Senthil K. Muthuswamy, University of Toronto, Toronto, Canada; Cold
Spring Harbor Laboratory, Cold Spring Harbor, New York, USA Loss of cell polarity and metastasis—Synergy with oncogenes or the
Lunch and Poster Viewing
Oral presentation of selected posters and awarding of poster prizes
Full list of posters begins on page xvii of the program
tArGetiNG tHe tUMOr MiCrOeNVirONMeNt
Chairperson: F. Balkwill,
Queen Mary University of London,United
Frances r. Balkwill, Barts Cancer Institute, Queen Mary University of
Targeting the peritoneal tumor microenvironment of high grade
serous ovarian cancer
Yutaka Kawakami, Keio University School of Medicine, Tokyo, Japan
mechanisms for cancer induced immunosuppression in tumor
associated microenvironments and their reversal by targeting altered
signaling pathways in cancer cells and immune cells
robert S. Kerbel, Sunnybrook Research Institute, Toronto, Canada
Differential therapeutic outcomes when treating primary orthotopic
tumors versus visceral metastases
Yona Keisari, Tel Aviv University, Tel Aviv, Israel
ablation of solid tumors by intratumoral pulsed electric currents or
alpha radiation activates anti-tumor immune responses that can target
residual disease
Jacques Pouyssegur, Institute for Research on Cancer and Aging
(IRCAN), University of Nice, CNRS, INSERM, Nice, France genetic disruption of CD147/ Basigin, a subunit of lactate-H+/
symporters (mCTs), sensitizes glycolytic tumour cells to phenformin
Submission to High Impact Journals
Discussion Leader: Nicola McCarthy, Chief Editor, Nature Reviews
Cocktails and Conference Dinner
SATUrDAY, NovEMbEr 17, 2012
Chairpersons: J.-P. Abastado,
A-STAR, Singapore
A. Porgador, Ben Gurion University of the Negev, Beer
Jean-Pierre Abastado, A-STAR, Singapore
Chemokines shape the immune tumor microenvironment
Angel Porgador, Ben-Gurion University of the Negev, Beer Sheva,
The function of NCRs in health and cancer—Emphasis on isoforms
Limin Zheng, Sun Yat-sen University, Guangzhou, China
Dynamic regulating the immune responses by different anatomic
areas in human tumors
reuven Stein, Tel Aviv University, Tel Aviv, Israel
CD38 deficiency in the tumor microenvironment attenuates glioma
progression and modulates features of tumor-associated microglia/
Viktor Umansky, German Cancer Research Center and University
Overcoming immunosuppression in melanoma microenvironment
induced by chronic inflammation
Coffee Break
Diane Damotte, Institut National de la Santé et de la Recherche
Médicale (INSERM), U872, Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie, Paris, France; Université Paris Composition, organization and clinical impact of the adaptive
and innate immune microenvironments in lung metastases from
colorectal and renal cell carcinoma
Alexandre Corthay, University of Oslo, Oslo, Norway
Tumor-specific Th2 cells collaborate with M2 macrophages to
eradicate cancer
Michal Baniyash, Hebrew University Hadassah Medical School,
Chronic inflammation-induced immunosuppression—Underlying
mechanisms and clinical implication in cancer
Cremer isabelle, UMRS 872 INSERM, Team 13, Paris, France
TLR7 in non-small cell lung carcinoma (NSCLC) patients—a double-
edged sword
Julia Kzhyshkowska, University of Heidelberg, Mannheim, Germany
Stabilin-1 is expressed on tumor-associated macrophages on early
stages in breast cancer and supports tumor growth in animal breast
cancer model by clearance of SPaRC
Arthur A. Hurwitz, National Cancer Institute, Frederick, Maryland,
Tumor-associated mast cells suppress anti-tumor immunity via
IL-13 and TgF-β
tArGetiNG tHe tUMOr AND tHe tUMOr
Chairpersons: r. Ge,
National University of Singapore, Singapore
t. ten Hagen, Erasmus Medical Center, Rotterdam, the
ruowen Ge, National University of Singapore, Singapore
Novel functions of a proteoglycanase— aDamTS5 (aggrecanase-2)
functions as an anti-angiogenic and anti-tumorigenic protein
independent of its proteoglycanase activity
Shelly Maman, Tel-Aviv University, Tel-Aviv, Israel; The Institute
of Human Virology, University of Maryland School of Medicine, micrometastasis regulation by the lung microenvironment in
timo LM. ten Hagen, Erasmus MC, Rotterdam, the Netherlands
Utilization and manipulation of the tumor microenvironment to
improve drug delivery to solid tumors
ingrid Herr, University of Heidelberg and German Cancer Research
Selection of established and primary models of pancreatic cancer
stem cells and therapeutic targeting
Liat Drucker, Tel Aviv University, Tel Aviv, Israel; Meir Medical Center,
Translation initiation as a novel platform for targeting myeloma-
microenvironment interactions
Coffee Break
Albrecht reichle, University Regensburg, Regensburg, Germany
a phase II study of Imatinib with pioglitazone, etoricoxib,
dexamethasone and low-dose treosulfan—Combined anti-osteoplastic,
anti-inflammatory, immunomodulatory and angiostatic treatment in
patients with CRPC
Zhengqiang Yuan, University College London, London, United
Reduction of lung metastasis by engineered mesenchymal stem cells
expressing TRaIL
Andrei V. Bakin, Roswell Park Cancer Institute, Buffalo, New York, USA
Targeting TAK1 in cancer progression and metastasis
Hélène Haegel, Transgene SA, Illkirch-Graffenstaden, France
an anti-CD115 monoclonal antibody targeting both tumor cells and
myeloid cells involved in cancer progression—Inhibition of osteoclast
and m2-polarized macrophages
Michael Grusch, Medical University of Vienna, Vienna, Austria
Deregulation of the FgF/FgF-receptor axis during melanoma
progression—Opportunities for simultaneous targeting of tumor cells
and the microenvironment
Martina Seiffert, German Cancer Research Center, Heidelberg,
The immunomodulatory drug lenalidomide reduces survival of
chronic lymphocytic leukemia cells by targeting the inflammatory
Shihui Liu, National Institute of Allergy and Infectious Diseases, NIH,
Treating solid tumors with tumor-associated protease-activated
anthrax toxins
Posters will be displayed for the duration of the conference
Jennifer H.e. Baker, University of British Columbia, Vancouver, Canada; BC
Cancer Research Centre, Vancouver, Canada
Investigating the highly heterogeneous distribution of trastuzumab in Her2-
overexpressing cancer xenografts using DCE-mRI and histology
Xingfeng Bao, Eisai Inc, Andover, Massachusetts, USA
antagonism of PgE receptor type-4 induces an effective anti-tumor immune
response by promoting aPC differentiation
Shijie Cai, University of Oxford, Oxford, United Kingdom; Huaqiao University,
Quanzhou, China
Stromal fibroblast GTP cyclohydrolase expression facilitates tumor
angiogenesis and progression
David W. Chan, The University of Hong Kong, Pokfulam, Hong Kong
The AMP-activated protein kinase gamma-2 (AMPK-γ2) subunit acts as a
modifier of AMPK activity in ovarian cancer cells
Mo Chen, National University of Singapore, Singapore
The novel angiogenesis inhibitor Isthmin inhibits angiogenesis through
gRP78-mediated internalization
Yu-Che Cheng, Academia Sinica, Taipei, Taiwan
BTG3 suppresses tumorigenesis and metastasis by antagonizing the AKT–
GSK3β–β-catenin signaling pathway
Valerie SP. Chew, Singapore Immunology Network, Singapore
Toll-like receptor 3-expressing tumor parenchyma and infiltrating natural
killer cells promote tumor control in hepatocellular carcinoma
Yoon Pyo Choi, Yonsei University College of Medicine, Seoul, South Korea
Synergistic effect for the combination of ILK and β4 integrin as an anticancer
target in ovarian cancer
Hila Confino, Sackler Faculty of Medicine, Tel - Aviv, Israel
Induction of anti-tumor immunity against experimental metastatic tumors
following tumor ablation by intratumoral Ra-224 loaded wires
Matthew t. Drake, Mayo Clinic, Rochester, Minnesota, USA
Overexpression of CCL3/mIP-1α induces diffuse bone loss in a novel murine
model of human multiple myeloma
Min Fang, Zhongnan Hospital of Wuhan University, Wuhan, China
Co-evolution of tumor microenvironment revealed by QDs-based multiplexed
imaging of hepatocellular carcinoma
eliane Fischer, Paul Scherrer Institute, Villigen, PSI, Switzerland
Targeting fibroblast activation protein (FAP) with phage-derived radiolabeled
Liang Han, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Sonic hedgehog signaling passage contributes to neurogenic pain through
stellate cells in pancreatic cancer
Ville Härmä, VTT Technical Research Centre of Finland, Turku, Finland
Quantification of dynamic morphological drug responses in 3D organotypic
cell cultures by automated image analysis
tal Hirschhorn, Tel Aviv University, George S. Wise Faculty of Life Sciences, Tel
Aviv, Israel
Differential regulation of Smad3 and of the type II transforming growth
factor-β receptor in mitosis—Implications for signaling
Dominique B. Hoelzinger, Mayo Clinic College of Medicine, Scottsdale,
Arizona, USA
administration of intratumoral Cpg-ODN and CCL1 depletion leads to
activated, cytolytic CD8+ T cells resistant to tolerization
Jason P. Holland, Harvard Medical School, Massachusetts General Hospital,
Boston, Massachusetts, USA
Designing radiotracers for non-invasive nuclear imaging of the tumor
esther Hoste, Cancer Research UK, Cambridge, United Kingdom
Characterization of a mouse model of wound-induced skin tumourigenesis
Yizhou Hu, University of Helsinki, Helsinki, Finland
Netrin-4 promotes glioblastoma cell proliferation via integrin beta-4 signaling
Bo Huang, Institute of Basic Medical Sciences, Chinese Academy of Medical
Biomechanical signaling—Implications in cancer and immunoregulation
Min-Chuan Huang, National Taiwan University College of Medicine, Taipei,
The molecular chaperone Cosmc enhances malignant behaviors of colon
cancer cells via activation of Akt and ERK
Marko Hyytiäinen, University of Helsinki, Helsinki, Finland
The signalling pathways mediating the effects of netrins on proliferation and
invasion of glioblastoma cells
takashi imai, National Institute of Radiological Sciences, Chiba, Japan
association of polymorphisms in hyaluronan receptor CD44 with radiotherapy
effectiveness in patients with cervical cancer
Sivan izraely, Tel Aviv University, Tel Aviv, Israel
Specificity and functions of molecules associated with melanoma brain
tianxia Jiang, Institute of Biophysics, Chinese Academy of Sciences, Beijing,
CD146 is a co-receptor for VEGFR-2 in tumor angiogenesis
Jing Jiao, University of California Los Angeles, Los Angeles, California, USA
Cell type specific role of COX2 on skin cancer development
Ki-rim Kim, Yonsei University College of Dentistry, Seoul, South Korea
15-deoxy-Δ12,14-prostaglandin J inhibits osteolytic bone metastasis of breast
cancer cells
Sara Lamorte, Instituto Português de Oncologia de Lisboa Francisco Gentil,
Lisbon, Portugal; University of Torino, Torino, Italy
multiple myeloma perivascular niche perturbs bone marrow function—Role of
delta like ligand 4
Nongnit Laytragoon-Lewin, Ryhov Hospital Clinical Microbiology, Jönköping,
Prognostic biomarkers, plasma CRP and TNFa on survival of head and neck
squamous cell carcinoma (HNSCC) patients
eun-Jung Lee, Yonsei University Health System, Seoul, South Korea
Down-regulation of IL-12 though IL-6 production increased treatment failure
after radiotherapy of hepatocellular carcinoma
Qun-Ying Lei, Fudan University,Shanghai Medical College, Shanghai, China;
Fudan University, Institutes of Biomedical Sciences, Shanghai, China
acetylation negatively regulates lactate dehydrogenase a and is
downregulated in pancreatic cancer
Kristina Levan, Sahlgrenska Cancer Center, Gothenburg, Sweden
Characterization of genes involved in epithelial mesenchymal transition in
SKOV-3 and OVCAR-3 cells
Bing Li, University of Minnesota, Austin, Minnesota, USA
adipose fatty acid binding protein accelerates cancer progression
Cong Li, Fudan University, Shanghai, China
Imaging intratumoral acidosis by using a pH-activatable near-infrared
fluorescence probe in vivo
Dan Liu, Vanderbilt University, Nashville, Tennessee, USA; Yale University, New
Haven, Connecticut, USA
Loss of LZaP inactivates p53 in head and neck cancer and regulates sensitivity
of cells to DNa damage in the p53-dependent manner
Li Liu, Institute of Basic Medical Sciences, Chinese Academy of Medical
Sciences & Peking Union Medical College, Beijing, China
The regulatory pathways and controlling mechanisms involved in NOK
oncogene mediated glucose metabolism
Li Liu, University of Heidelberg and German Cancer Research Center,
Triptolide from TCm abolishes NF-κB-signaling, EmT and stem-like features in
an hypoxic microenvironment of pancreatic cancer
Su Hao Lo, University of California - Davis, Sacramento, California, USA
Cten functions as a novel quantity controller of epidermal growth factor
Noor A. Lokman, University of Adelaide, Adelaide, Australia
annexin a2 released during ovarian cancer-peritoneal cell interaction
promotes a pro-metastatic cancer cell behaviour
ida Lundberg, Umeå University, Umeå, Sweden
Different subgroups of colorectal cancer and adjacent fibroblasts
Samuel Lundin, University of Gothenburg, Gothenburg, Sweden
Cancer associated fibroblast (CAF) footprints in the transcriptional profiles of
gastric tumor- and non-tumor tissue
Yunus A. Luqmani, Kuwait University, Safat, Kuwait
Factors influencing proliferation and invasion of endocrine resistant breast
cancer cells
tsipi Meshel, Tel-Aviv University, Tel-Aviv, Israel
Mechanisms regulating the secretion of the inflammatory chemokine CCL2 in
breast tumor cells
tsipi Meshel, Tel-Aviv University, Tel-Aviv, Israel
The role of PhoX2B in micro and macro metastases of neuroblastoma
Adriana Michielsen, Institute of Molecular Medicine, St. James’s Hospital,
Trinity College Dublin, Dublin, Republic of Ireland
The tissue microenvironment in Barrett’s Oesophagus induces dendritic cell
Neda Moazzezy, Pasteur Institute of Iran, Tehran, Iran
Biomarker expression in blood and tissue of breast cancer patients
elin Möllerström, Sahlgrenska Academy, University of Gothenburg, Göteborg,
Subpopulations of cells within human astrocytomas determined by single cell
gene expression profiling
Jennifer M. Munson, Ecole Polytechnique Federale de Lausanne, Lausanne,
Lymphatic endothelial cell-induced stromal stiffening caused by activation of
fibroblasts in the tumor microenvironment
Daotai Nie, Southern Illinois University School of Medicine, Springfield,
Illinois, USA
microenvironmental regulation of tumor metastasis through thromboxane a2-
receptor signalling axis
Se Young Park, Yonsei University College of Dentistry, Seoul, South Korea
Inhibitory effect of betulinic acid on breast cancer-associated bone diseases
e Pomianowska, University of Oslo, Oslo, Norway
Role of cyclooxygenase-2 and prostaglandin E2 in stellate cells from
pancreatic cancer
Yael raz, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of
Medicine, Tel Aviv University, Tel Aviv, Israel.
Characterization of cancer associated fibroblasts in mammary gland
Albrecht reichle, University Regensburg, Regensburg, Germany
Biomodulatory therapy approaches—Renal clear cell carcinoma
Albrecht reichle, University Regensburg, Regensburg, Germany
Formal-pragmatic communication theory as prerequisite for an evolution-
adjusted tumor pathophysiology
Albrecht reichle, University Regensburg, Regensburg, Germany
Practical relevance of an evolution theory for understanding tumor
development and for specifying tumor therapy
thomas reinheckel, Albert-Ludwigs-University, Freiburg, Germany
Cysteine cathepsins as tumor-promoting extracellular proteases in the
microenvironment of murine breast cancer
Carmela ricciardelli, University of Adelaide, Adelaide, Australia
Carboplatin-induced hyaluronan production—a chemoresistance mechanism
in ovarian cancer
Orit Sagi-Assif, Tel-Aviv University, Tel-Aviv, Israel
The metastatic microenvironment—Survival of melanoma cells in the brain is
regulated by interactions with the brain microenvironment
Francis H.W. Shand, University of Tokyo, Tokyo, Japan; CREST, Tokyo, Japan;
University of Melbourne, Parkville, Australia The contribution of spleen-pool myeloid cells to tumor infiltration
Yoray Sharon, Tel-Aviv university, Tel-Aviv, Israel
Mammary fibroblasts are activated to become pro-inflammatory by breast
tumor cells
elin Sjoberg, Karolinska Institute, Stockholm, Sweden
Towards identification of a receptor for the orphan chemokine CXCL14
Alex Soltermann, University Hospital Zurich, Zurich, Switzerland
Epithelial-mesenchymal transition at the tumor-stroma interface of non-small
cell lung carcinoma
rakesh Srivastava, University of Kansas Medical Center, Kansas City, USA
Clinical potential of NPV-LDE-225 (Erismodegib) for the treatment of brain
cancer by targeting glioblastoma initiating cells
Olga tatti, Helsinki University, Research Program Unit, Helsinki, Finland
mT3-mmP regulates melanoma growth and vascular intravasation
Alimatou M. tchafa, Drexel University, Philadelphia, Pennsylvania, USA
Combined role of interstitial fluid flow and ErbB2 expression on breast cancer
timo LM. ten Hagen, Erasmus MC, Rotterdam, the Netherlands
melanoma and endothelial cell communication affect tumor aggressiveness
Chia-Lung tsai, Chang-Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan
Secreted stress-induced phosphoprotein 1 activates the ALK2-SMAD signaling
pathways and promotes cell proliferation of ovarian cancer cells
Nithya rao Velliyuir Nott, National University of Singapore, Singapore
aDamTS4—a new role in angiogenesis and cancer
Juan-Jose Ventura, University of Cambridge, Cambridge, United Kingdom
Unraveled a paracrine network underlying the potential of human lung stem
cells to establish their own niche
Bo Wang, State Key Laboratory of Oncology in South China, Guangzhou,
mast cells in muscularis propria producing interleukin 17 predicts favorable
prognosis in esophageal squamous cell carcinoma
Yuan Yuan Wang, IPBS CNRS UMR 5089, Toulouse, France; INSERM U1048,
Toulouse, France; The First Affiliated Hospital of Chongqing Medical University, ChongQing, China
Tumor-surrounding adipocytes provide energetic support to breast cancer
cells, through fatty acid β-oxidation, to promote tumor progression
Julia e. Wells, Telethon Institute for Child Health Research, Perth, Australia;
University of Western Australia, Perth, Australia
In vivo model to determine the role of connective tissue growth factor (CTgF)

in childhood leukaemia
Hui Z. Xie, State Key Laboratory of Molecular Oncology, Beijing, China
IQGAP1 knockdown induced anoikis by inhibition of Erk1/2 and S6K activity
in Eca109, HB99 and HCT116 cell lines
Dan Xu, Dalian Maritime University, Dalian, China
miR-22 is involved in the cytotoxic effect of endosulfan on human endothelial
Lixia Xu, Nankai University, Tianjin, China
Death receptor-3 is a key mediator of TNFα- and TNFSF15-induced
endothelial cell apoptosis
Celestial t. Yap, Yong Loo Lin School of Medicine, National University of
Singapore, Singapore
gelsolin modulates the expression of extracellular matrix components in colon
tsz-Lun Yeung, University of Texas MD Anderson Cancer Center, Houston,
Texas, USA
TgF-β induced stromal versican promotes cancer invasion in advanced stage
serous ovarian cancer
irene Ylivinkka, University of Helsinki, Helsinki, Finland
Netrin-1 promotes the invasiveness and survival of human glioblastoma cells
Mingo M. H. Yung, The University of Hong Kong, Hong Kong SAR, China
Bitter melon extract (BME) used as natural AMPK activator in inhibiting
ovarian cancer cells growth
Yiyao Zhang, University of Heidelberg and German Cancer Research Center,
Heidelberg, Germany
aspirin-sensitizes pancreatic cancer to chemotherapeutic drugs by inhibition
of cancer stem cell features
Bo Zhu, Xinqiao Hospital Institute of Cancer, Chongqing, China
IL-17 produced by tumor microenvironment promotes self-renewal of cancer
stem cells in ovarian cancer


Contents book

Contents book 1 Introduction The World’s Best Kept Secret About the Author Jenny’s Story Acknowledgements To True Friends The humble beginnings of NPAN and the need for information What compels, inspires and influences me as a woman, as a natural progesterone advocate, consultant and author CHAPTER 1 Testimonials from women CHAPTER 2 Attitudes Towards Proges

Prosp. lotemicin ingles.indd

risk of secondary ocular infections. Pharmacological features: In those diseases causing thinning of the cornea or sclera, the use of topical steroids may cause Use in pediatrics LOTEMICIN® Pharmacological action perforations. In acute ocular purulent diseases, steroids may hide or exacerbate the existing Safety and effectiveness of LOTEMICIN® have not been established in

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