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1) D Gallo, I De Stefano, MG Prisco, G Scambia, G Ferrandina. Estrogen Receptor Beta in Cancer: an
Attractive Target for Therapy. Current Pharmaceutical Design 2012 Feb 28. 2) MG Prisco, GF Zannoni, I De Stefano, VG Vellone, L Tortorella, A Fagotti, L Mereu, G Scambia,
D Gallo. Prognostic role of Metastasis Tumor Antigen 1 (MTA1) in ovarian cancer patients: a clinical study. Human Pathology 2012; 43(2):282-8 3) GF Zannoni, MG Prisco, VG Vellone, I De Stefano, G Vizzielli, L Tortorella, A Fagotti, G
Scambia, D Gallo. Cytoplasmic expression of Estrogen Receptor beta (ERβ) as a prognostic factor in vulvar squamous cell carcinoma in elderly women. Hystopatology 2011; 59(5): 909-17. 4) I De Stefano, GF Zannoni, MG Prisco, A Fagotti, L Tortorella, G Vizzielli, L Mencaglia, G
Scambia, D Gallo. Cytoplasmic expression of estrogen receptor beta (ERβ) predicts poor clinical outcome in advanced serous ovarian cancer. Gynecology Oncology 2011; 122(3):573-9. 5) M Mancuso, S Leonardi, P Giardullo, E Pasquali, F Borra, I De Stefano, MG Prisco, M Tanori, G
Scambia, V Di Majo, S Pazzaglia, A Saran, D Gallo. The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways. Cancer Letter 2011; 308(2):197-202. 6) I De Stefano, A Battaglia, GF Zannoni, MG Prisco, A Fattorossi, D Travaglia, S Baroni, D Renierd,
G Scambia, C Ferlini, and D Gallo. Hyaluronic acid-Paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts. Cancer Chemotherapy and Pharmacology 2011; 68(1):107-16. 7) GF Zannoni, MG Prisco, VG Vellone, I De Stefano, G Scambia, D Gallo. Changes in the expression
of Estrogen Receptors and E-cadherin as molecular markers of progression from normal epithelium to invasive cancer in elderly patients with vulvar squamous cell carcinoma: a pilot study. Histopathology 2011; 58(2):265-75. 8) M Mancuso, S Leonardi, M Ceccarelli, E Pasquali, I De Stefano, MG Prisco, S Rebessi, M Tanori,
G Scambia, V Di Majo, S Pazzaglia, A Saran and D Gallo Protective role of 17 beta-estradiol on medulloblastoma development in Patched1 heterozygous mice. International Journal of Cancer 2010; 127(12):2749-57. 9) I De Stefano, G Raspaglio, GF Zannoni, D Travaglia, MG Prisco, C Ferlini, G Scambia, G Scambia
and D Gallo. Antiproliferative and antiangiogenic effects of the of the Benzophenanthridine alkaloid Sanguinarine in melanoma. Biochemical Pharmacology 2009; 78(11):1374-81. 10) M Mancuso, D Gallo, S Leonardi, M Pierdomenico, E Pasquali, I De Stefano, S Rebessi, M Tanori,
G Scambia, V Di Maio, V Covelli, S Pazzaglia, A Saran. Modulation of Basal and Squamous Cell Carcinoma by Endogenus Estrogen in Mouse Model of Skin Cancer. Carcinogenesis 2009; (2): 340-7. 11) D Gallo, GF Zannoni, I De Stefano, M Mosca, C Ferlini, E Mantuano G Scambia. Soy
phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice. Journal of Nutrition 2008; 138(7): 1360-4. 12) D Gallo, A Battaglia, E Mantuano, D Travaglia, I De Stefano, A Buzzonetti, G Scambia. 17β-
Estradiol and soy-phytochemicals selectively induce a type 2 polarization mesenteric lymph nodes of ovariectomized rats. Menopause 2008; 15(4Pt1): 718-25. 13) D Gallo, GF Zannoni, M Fabrizi, I De Stefano, E Mantuano, G Scambia. Comparative effects of
17β-estradiol and phytoestrogens in the regulation of endometrial functions in the rodent uterus. Journal of Endocrinological Investigation 2008; 31(1): 48-56. 14) D Gallo, E Mantuano, M Fabrizi, C Ferlini, S Mozzetti, I De Stefano and G Scambia. Effects of
phytoestrogen-containing soy on the growth-inhibitory activity of ICI 182 720 in an experimental model of estrogen-dependent breast cancer. Endocrine-Related Cancer 2007; 14(2): 317-324.

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A DOUBLE-BLIND, RANDOMIZED, PHASE 2 STUDY TO COMPARE THE SAFETY AND EFFICACY OF INTRAVENOUS CXA-101 (CXA) AND INTRAVENOUS CEFTAZIDIME (CTZ) IN COMPLICATED URINARY TRACT INFECTION (cUTI) O. UMEH1, D. CEBRIK2, I.R. FRIEDLAND1 1Cubist Pharmaceuticals, Inc., Lexington, MA ; 2Axistat, Inc., San Francisco, CA Background: CXA-101 is a novel parenteral broad-spectrum cephalosporin with


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