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Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
Gibson, Laura F., Ph.D.
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
West Virginia University, Morgantown, WV
West Virginia University, Morgantown, WV
A. Positions and Honors.
Positions and Employment
1991-1995 Postdoctoral Fellow, Mary Babb Randolph Cancer Center West Virginia University,
Assistant Professor, Department of Pediatrics, West Virginia University School of Medicine, Morgantown, WV
Adjunct Assistant Professor, Department of Microbiology and Immunology, West Virginia University, Morgantown, WV
Associate Professor and Vice Chair for Research, Department of Pediatrics, West Virginia School of Medicine, Morgantown, WV
Adjunct Associate Professor, Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV
Professor and Vice Chair for Research, Dept. of Pediatrics, and Adjunct Professor, Dept. of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV
Alexander B. Osborn Distinguished Professor in Hematologic Research; Mary Babb Randolph Cancer Center and Professor, Dept. of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV
Deputy Director, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV
Other Experience and Professional Memberships
Cancer Research Institute Postdoctoral Fellow
Association for Women in Science American Association for Cancer Research American Society of Hematology International Society of Experimental Hematology
Department of Pediatrics Outstanding Research Award
Department of Pediatrics Outstanding Research Award
Dean’s Award for Excellence in Research
Nominated for Outstanding Teacher of the Year
B. Selected peer-reviewed publications (in chronological order oldest to newest).
1. Gibson LF
, Piktel D, Landreth KS. Insulin-like growth factor-1 potentiates expansion of interleukin-7-
dependent pro-B cells. Blood. 1993;82(10):3005-11.
2. Gibson LF
, Piktel D, Narayanan R, Nunez G, Landreth KS. Stromal cells regulate bcl-2 and bax
expression in pro-B cells. Exp.Hematol. 1996;24(5):628-37.
3. Gibson LF
, Fortney J, Landreth KS, Piktel D, Ericson SG, Lynch JP. Disruption of bone marrow stromal
cell function by etoposide. Biol.Blood Marrow Transplant. 1997;3(3):122-32.
4. Ericson SG, Zhao Y, Gao H, Miller KL, Gibson LF
, Lynch JP, Landreth KS. Interleukin-6 production by
human neutrophils after Fc-receptor cross-linking or exposure to granulocyte colony-stimulating factor. Blood. 1998;91(6):2099-107.
5. Gibson LF
, Fortney J, Magro G, Ericson SG, Lynch JP, Landreth KS. Regulation of BAX and BCL-2
expression in breast cancer cells by chemotherapy. Breast Cancer Res.Treat. 1999;55(2):107-17.
6. Hahn BK, Piktel D, Gibson LF
, Landreth KS. Hematopoiesis: The Role of Stromal Integrin Interactions in
Pro-B Cell Proliferation. Hematology. 2000;5(2):153-60.
7. Mudry RE, Fortney JE, York T, Hall BM, Gibson LF
. Stromal cells regulate survival of B-lineage leukemic
cells during chemotherapy. Blood. 2000;96(5):1926-32.
8. Fortney JE, Zhao W, Wenger SL, Gibson LF
. Bone marrow stromal cells regulate caspase 3 activity in
leukemic cells during chemotherapy. Leuk.Res. 2001;25(10):901-7.
9. Frost LL, Neeley YX, Schafer R, Gibson LF
, Barnett JB. Propanil inhibits tumor necrosis factor-alpha
production by reducing nuclear levels of the transcription factor nuclear factor-kappab in the macrophage cell line ic-21. Toxicol.Appl.Pharmacol. 2001;172(3):186-93.
10. Hall BM, Fortney JE, Gibson LF
. Alteration of nuclear factor-kappaB (NF-kappaB) expression in bone
marrow stromal cells treated with etoposide. Biochem.Pharmacol. 2001;61(10):1243-52.
11. Fortney JE, Hall BM, Bartrug L, Gibson LF
. Chemotherapy induces bcl-2 cleavage in lymphoid leukemic
cell lines. Leuk.Lymphoma. 2002;43(11):2171-8.
12. Gibson LF
. Survival of B lineage leukemic cells: signals from the bone marrow microenvironment.
13. Hall BM, Fortney J, Gibson LF
. Human bone marrow stromal cell SDF-1 production is reduced following
exposure to etoposide or doxorubicin. Analytical Pharmacology. 2003;4:21-9.
Hogan MB, Weissman DN, Hubbs AF, Gibson LF
, Piktel D, Landreth KS. Regulation of
eosinophilopoiesis in a murine model of asthma. J Immunol. 2003;171(5):2644-51.
15. Adams SW, Wang L, Fortney J, Gibson LF
. Etoposide differentially affects bone marrow and dermal
derived endothelial cells. J Cell Mol.Med. 2004;8(3):338-48.
16. Hall BM, Gibson LF
. Regulation of lymphoid and myeloid leukemic cell survival: role of stromal cell
adhesion molecules. Leuk.Lymphoma. 2004;45(1):35-48.
17. Hall BM, Fortney JE, Taylor L, Wood H, Wang L, Adams SW, Davis S, Gibson LF
. Stromal cells
expressing elevated VCAM-1 enhance survival of B lineage tumor cells. Cancer Lett. 2004;207(2):229-39.
18. Peister A, Mellad JA, Larson BL, Hall BM, Gibson LF
, Prockop DJ. Adult stem cells from bone marrow
(MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood. 2004;103(5):1662-8.
19. Wang L, Fortney JE, Gibson LF
. Stromal cell protection of B-lineage acute lymphoblastic leukemic cells
during chemotherapy requires active Akt. Leuk.Res. 2004;28(7):733-42.
20. Clutter SD, Fortney J, Gibson LF
. MMP-2 is required for bone marrow stromal cell support of pro-B-cell
chemotaxis. Exp.Hematol. 2005;33(10):1192-200. PMCID: PMC1774816.
21. Wang L, Chen L, Benincosa J, Fortney J, Gibson LF
. VEGF-induced phosphorylation of Bcl-2 influences
B lineage leukemic cell response to apoptotic stimuli. Leukemia. 2005;19(3):344-53.
22. Wang L, Clutter S, Benincosa J, Fortney J, Gibson LF
. Activation of transforming growth factor-
beta1/p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow damage. Stem Cells. 2005;23(8):1122-34.
23. Wang L, Coad JE, Fortney JM, Gibson LF
. VEGF-induced survival of chronic lymphocytic leukemia is
independent of Bcl-2 phosphorylation. Leukemia. 2005;19(8):1486-7.
24. Clutter SD, Fortney JE, Gibson LF
. Chemotherapy disrupts activity of translational regulatory proteins in
bone marrow stromal cells. Exp.Hematol. 2006;34(11):1522-31.
25. Wang L, O'Leary H, Fortney J, Gibson LF
. Ph+/VE-cadherin+ identifies a stem cell like population of
acute lymphoblastic leukemia sustained by bone marrow niche cells. Blood. 2007;110(9):3334-44. PMCID: PMC2200915.
26. Yossuck P, Nightengale BJ, Fortney JE, Gibson LF
. Effect of morphine sulfate on neonatal neutrophil
chemotaxis. Clin.J Pain. 2008;24(1):76-82.
27. Wang L, O’Leary H, Gibson LF
. 2009 Bone Marrow Microenvironment Modulation of Ph+ Hematopoietic
Malignancies in Cancer Genome and Tumor Microenvironment; Springer Press. In press.
28. Othumpangat S, Gibson LF
, Samsell L, Piedimonte G. 2009 Nerve growth factor is essential for the
survival of human bronchial epithelial cells infected with Respiratory Syncytial Virus. PLoS.One. In Press.
C. Research Support.
Ongoing Research Support
NIH The Role of the Stem Cell Niche in ALL. The goals of this project are to delineate critical signals in the marrow microenvironment that modulate the stem cell phenotype of tumors and subsequently their therapeutic response. Role: PI R01 HL056888 Gibson (PI)
NIH Stromal Cell Function Following Chemotherapy. The goals of this project are to understand the mechanisms that underlie diminished hematopoietic support capacity in stromal cells exposed to aggressive chemotherapy. Role: PI P20 RR16440 Gibson (PI as of 2/1/2009)
NIH/NCRR CoBRE for Signal Transduction and Cancer. The goals of this project are to nurture collaborative interactions, support core facilities, and mentor junior scientists involved in studies of signal transduction in cancer. Role: PI P20 RR016440 Gibson (PI)
NIH/NCRR Cobre for Signal Transduction and Cancer: NCRR ARRA Supplement – Translational This research will develop an accurate prognostic model by combing patient gene expression profiles, demographic, clinical, pathological, and social ecological factors to predict lung cancer recurrence. Role: PI NCS-07-11 Cottrell, L. (PI)
NIH/NICHA National Children’s Study (NCS); Option Location Marion County (Sub-contract) NIH-NICHA-NCS-07-11 The goal of this project is contribution to a national level effort to investigate interactions between genetic and environmental exposures to specific developmental outcomes over time. Role: Co-I L.F. 5 P20 RR020180-05 Niles (PI)
NCI/NCRR CoBRE Transcription Factors in Cancer NCRR-ARRA Supplement - Translational (Sub-contract) The goal of this work is to establish a statewide network of banked tumor cells, with technically consistent processing, to allowing subsequent sharing of genomic based data relative to specific malignancies.
Blood (ASH Annual Meeting Abstracts) 2007 110: Abstract 2724 © 200 Poster Session Myeloma: Relapsed and Refractory Multiple Myeloma Myeloma - Therapy, excluding Transplantation PAD Given at Relapse Is More Effective Than VAD Given as Induction Therapy - Results of a Phase II Study. Treen C. Morris1, Paul J. Kettle1, Mary B. Drake1, Aisleen Brunton2,*, Gordon Cook3, Maeve Leahy4,
Claudication Treatment Comparative Effectiveness: Authors: Timothy P Murphy, Donald E. Cutlip, Judith G. Regensteiner, Emile R. Mohler III, David J. Cohen, Matthew R. Reynolds, Beth A. Lewis, Joselyn Cerezo, Niki C. Oldenburg, Claudia C. Thum, Alan T. Hirsch. Presenter: Alan T. Hirsch, Chair, on behalf of the CLEVER Study Investigators Acknowledgements and Disclosures Ackn