Microsoft word - microbio showtunes.doc
Antimicrobials 1, to the tune of “Think of Me”
Beta-lactams bind transpeptidases, preventing
formation of crosslinks in the peptidoglycan layer
Glycopeptides (the only one we have available is
peptidoglycan chain, preventing further cell wall
Beta-lactams kill where cell walls grow,
Don’t combine B-lactams with bacteriostatic
They won’t work if static drugs make wall
drugs! They are most effective on active bacteria
Strep pneumo is the most common organism in
both CAP and nosocomial pneumonia (about 1/3)
H influenzae and Klebsiella are the next most
likely etiologic agents for CAP severe enough to
require hospitalization. Other causes of milder
pneumoniae, viruses, Legionella). Standard tx
for hospitalized pts is a B-lactam (PCN or
ceftriaxone) and azithromycin (other regimens
for elder/high risk, outpatient, and aspiration).
Natural PCNs are drug of choice for GAS, also
used for syphilis and Lyme dz (both spirochetes).
Aminopenicillins are active against some G(-)
including Proteus mirabilis, non B-lactamase-
inhibitor (e.g., clavulanate) have expanded
Piperacillin/tazobactam covers Pseudomonas.
UTI’s, to the tune of “Castle on a Cloud”
hematogenous seeding can occur with (subacute)
bacterial endocarditis or tuberculosis. Alkaline
urine (e.g., when Proteus makes urease) and
Etiologic agent is usually E coli; other agent for
Check for systemic/bacteremic infection with
Standard tx for uncomplicated UTI is TMP-sulfa.
If pt has sulfa allergy, nitrofurantoin can be used.
Fluoroquinolones can be used for complicated
[Extra notes that I couldn’t fit into the song: Complicated acute cystitis: stones, DM, upper UTI, men, pregnant women, resistant bacteria (recurrent, nosocomial), recent instrumentation. Test for pregnancy BEFORE choosing drug – could be toxic to fetus. N gonorrheae and Chlamydia trachomatis: urethritis in men, cervicitis in women. Co-infection 25%. Treat both: ceftriaxone(3G) (single IM dose) for gonococcus, azithromycin (single PO dose) for chlamydia.]
Antimicrobials 2 - meningitis, to the tune of “Don’t Stop Believin’”
Complement is down, meningococcus going ’round, Susceptibility to N meningitides if complement But pneumococcus wins 3 times out of 5.
deficient. 60% of adult bacterial meningitis is
Antibodies low, H. flu’s gonna steal the show.
due to S pneumo. Susceptibility to H influenzae
if humoral immunity is weak. The elderly and
meningitis due to Listeria monocytogenes.
Fluoroquinolones and tetracyclines are potential
Rx for meningitis, but they can cause fetal
abnormalities. So can Bactrim (TMP-SMX).
Beta-lactams are the penicillins, cephalos,
The beta-lactams. 3rd and 4th generation
cephalosporins have good CNS penetration.
[Note also: Ceph-3s are divided into anti-
Pseudomonas (ceftazidime) or not (ceftriaxone).]
Carbapenems are good broad-spectrum agents
but might cause seizures, esp w/ CNS dz (bad for
Poor CNS penetration w/ macrolide and Ceph-1.
Pregnancy = immunocompromised state, at risk
for meningitis due to Listeria (small G(+) rod).
[Beta-lactams, are the penicillins, cephalos,
Hold onto the feelin’ Streetlight people….]
Photomedicine and Laser SurgeryVolume 26, Number 4, 2008© Mary Ann Liebert, Inc. Pp. 393–400DOI: 10.1089/pho.2007.2144Low-Level Laser Therapy in the Prevention and Treatmentof Chemotherapy-Induced Oral Mucositis in Young PatientsMeire Maman Fracher Abramoff, D.D.S.,6 Nilza Nelly Fontana Lopes, D.D.S., M.S.,1Luciana Almeida Lopes, D.D.S., M.S., Ph.D.,2 Luciano Lauria Dib, D.D.S., M.S., Ph.D.
International Journal of Bioinformatics and Biological Science: v.1 n.1 p.71-77. March, 2013 Antimicrobial properties of tea tree oil Puja Kumari Jacob School of Biotechnology and Bioengineering, SHIATS, Allahabad, UttarPradesh, India*Corresponding Author: Puja Kumari [email protected] ABSTRACT Phytomedicine such as tea tree (melaleuca) oil have become increasingly popularin recent de