Tadalafil appartiene alla classe degli inibitori selettivi della fosfodiesterasi di tipo 5, con un profilo farmacocinetico caratterizzato da un’emivita terminale di circa diciotto ore. Dopo somministrazione orale viene assorbito rapidamente e raggiunge concentrazioni plasmatiche massime in due ore. La biotrasformazione avviene principalmente tramite CYP3A4 con formazione di metaboliti inattivi, escreti in prevalenza con le feci. L’elevato legame alle proteine plasmatiche (>90%) assicura una distribuzione stabile. Nei confronti delle altre molecole della stessa classe, cialis compresse italia è noto per la durata prolungata dell’attività farmacologica.

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ADR 會議內容統計
討論(件) 通報(件) 未通報(件) 通報藥物-ADR(件) Fungizone®--Fever(1) Tegretol®--SJS(1) Tegretol®--General erythematous papules(1) Tazocin®--Skin eruption(1) Ticlid®--Cholestatic hepatitis(1) NPH/RI®--Skin allergy(1) Vancomycin®--Toxic erythema(1) Lamisil®-- Cholestatic hepatitis(1) Glucophage®--Hepatitis(1) Amaryl®-- Cholestatic hepatitis(1) Wintermin®--Hypotension(1) Cataflam®--SJS(1) Dilantin®--Erythema multiforme(1) Myambutol®--SJS(1) Lopid®--Rhabdomyolysis(2) Ticlid®--Acute Cholestatic hepatitis(1) Nizoral®-- Acute hepatitis(1) Cataflam®-- Acute hepatitis(1) Salazopyrin®--SJS(1) Somatosan®--Delirium(1) Euglucon®--Hypoglycemia(1) Dogmatyl®--Galactorrhea(1) Cleocin®--Granulocytopenia(1) Ticlid®--Acute hepatitis(2) Salazopyrin®-- Acute hepatitis(1) Ponstan®,Doxymycin®,Keflex®,Cleocin®,Cataflam®,Premarin®, Anaprox®-Esophagitis(共 7 個藥 10 件案例) Cataflam®--Hepatitis(1) Tazocin®--Thrombocytopenia(1) Isoniazid®+Rifampin®--Hepatotoxicity(2) Isoniazid®+Rifampin®+Pyrazinamide®--Hepatotoxicity (2) Rifater®--Hepatotoxicity (10) Ciproxin®等 antibiotics –Pseudomembranous colitis(1) Rifater®--Jaundice(1) Haldol®--SIADH(1) Nimotop®--Hepatotoxicity(1) Ulex®--Skin rash(1) Wintermin®--Pancytopenia(1) Zantac®--SJS(1) Targocid®--Pancytopenia(1) Cataflam®--Oral ulcer(1) Nimotop®+Panamax®--Hepatotoxicity(1) Nimotop®+Panamax®+Acemet®--Hepatotoxicity(1) Nimotop®+Panamax®+Diprivan®+Dexamethasone®--Hepatotoxicity(1) Nimotop®+Dexamethasone®+Dilantin®--Hepatotoxicity(1) Nimotop®+Dexamethasone®--Hepatotoxicity(1) Nimotop®+Diprivan®+Dexamethasone®--Hepatotoxicity(1) Nimotop®+Diprivan®+Dilantin®+Panamax®--Hepatotoxicity(1) Mepem®-- Pancytopenia(2) Mannitol®+Gentamycin®–Acute renal failure(1) Ketoprofen®---SJS & Acute hepatitis(1) Rifampicin®--Thrombocytopenia(1) INAH®+MIDE®--Hepatotoxicity(1) Echinops latifolis®--Neutropenia(1) Nootropil®--Skin allergy(1) Targocid®--Allergy(1) Vincristine®--Neuropathy(1) ADR 會議內容統計
Nimotop®+Tinten+Propofol®--Hepatotoxicity(2) Nimotop®+Dexamethasone®--Hepatotoxicity(1) Keto®--Allergy(1) Procil®--Skin allergy(1) Chlorzoxazone®--Skin rash(1) Rifater ®--Hepatotoxicity(2) Gentamycin® --Renal failure(1) Glivec®--Muscle clonus and periorbital swelling--(1) Ponstan® ---Eye swelling(1) Ponstan® ---Eye swelling and skin rash(1) Acemet®--- Eye swelling(1) Ibuprofen®---Erythema multiforme(1) Keto®--- Erythema multiforme(1) Cataflam®,Dorsiflex®---Skin rash(1) Cabudan®,Rasitol®---Skin rash(1) Novamin®---Mouth numberness,cheek swelling,dyspnea(1) Cleocin®---Skin rash(1) Doxymycin®---Phototoxicity(1) Rifampicin®—Skin rash(1) Targocid®---Skin rash(1) Diflucan®---Skin rash(1) Augmentin®,Amoxicillin®--- Erythema multiforme(1) Baktar®---Pustular drug eruption(1) Allopurinol®---Generalized erythroderma(1) Dilantin®,Lamictal®,Depakine®,Phenobarbital®---Skin rash(1) Lamictal®,Depakine®---Maculopapular skin rash(1) Tegretol®---SJS(1) Dilantin®---SJS(1) Allopurinol®---SJS(1) Aminophylline----nausea, vomiting and tachycardia(1) Uformin® ---- allergy(1) Cataflam® ----allergy(1) Keto®------allergy(1) Gentamycin®-----Acute Renal Failure(2) Gentamycin® & Aprovel®----- Acute Renal Failure(1) Gentamycin® & Accupril®----- Acute Renal Failure(1) Cataflam®-----acute renal failure(1) Nimed® & Hyzaar®-----acute renal failure(1) Hyzaar® & COX 2 inhibitor -----acute renal failure(1) Ipratran®-----skin rash(3)
Ipratran®-----allergy(4)
IVIG-----hypoxia, cyanosis, hypotonia, and apnea(1)
Fosamax®-----allergy(1)
Dilantin®-----allergy(1)
Dilantin®-----skin rash(1)
Gefitinib-----drug eruption(1)
Oxacillin------phlebitis(1)
Ibuprofen -----skin rash(1)
Ponstan®-----skin rash(1)
Ponstan®-----allergy(1)
Keto®------skin rash(1)
Keto®-----allergy(1)
Cataflam®-----allergy(1)
Hiconcil® ----- skin rash(1)
Ibuprofen®-----allergy(1)
Vioxx®-----skin rash(1)
Keto®, cefamezin®-----skin rash(1)
ADR 會議內容統計

Source: http://psi.tmu.edu.tw/file/ADR%E9%80%9A%E5%A0%B1%E7%B5%B1%E8%A8%88/ADR%E9%80%9A%E5%A0%B1%E7%B5%B1%E8%A8%88-%E8%97%A5%E7%89%A9(93.6.17).pdf