Mais les résultats doivent être attendus longtemps et il n'y a généralement pas de temps doxycycline prix L'autre cas, c'est que l'achat d'un ou d'un autre antibiotique dans une pharmacie classique nécessite des dépenses matérielles considérables et pas toutes les personnes ne peuvent acheter des produits pharmaceutiques aussi coûteux.
Continuous caudal epidural analgesia in a patient with an implanted intrathecal baclofen pump
Continuous caudal epidural analgesia in a patient with an implanted intrathecal baclofen pump
Affiliation: Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada
Introduction: The use of epidural analgesia in patients with implanted intrathecal delivery devices is somewhatcontroversial. Major concerns include the risk of damaging the intrathecal catheter, the risk of infection, and the potential forinteraction between the epidurally-administered and the intrathecally-delivered medication. In children with cerebral palsy,intrathecal administration of baclofen permits significantly higher CSF concentrations of the drug than with oraladministration, allowing for greater reduction in spastic tone and lower incidence of side effects (1). Epidural analgesia is anattractive option for postoperative analgesia in these patients, who frequently have co-existing medical issues making the useof intravenous opioids for pain less desirable (2). In addition, cognitive impairment, visual or hearing loss, andcommunication or behavioural disturbances can make pain measurement difficult. This report describes the successful use ofcontinuous caudal epidural analgesia in a patient with an implanted intrathecal baclofen pump.
Case report: An 8 year-old, 29kg male patient presented to this institution for multi-level pelvic and femoral osteotomies,tenotomies, soft tissue releases, and Botox injections for a paralytic subluxation of the right hip. His past medical history wassignificant for premature birth at 24 weeks gestation, severe developmental delay, cortical blindness, and spasticquadriparesis with choreoathetosis. After a period of enteral baclofen therapy, an intrathecal baclofen pump was implantedwhen the patient was 7 years of age. The tip of the catheter was at the T4-5 level. The patient was non-verbal and wheelchair-bound. He had a history of dysphagia, mild gastroesophageal reflux and had no intake per os
Epidural analgesia was considered to be desirable for this patient by both the anesthesia and surgical teams, due to
the complexity of the procedure, the patient’s co-existing medical conditions, and the potential difficulty in postoperativepain assessment. Upon examination of the patient the surgical scar from the intrathecal pump placement was at the level ofL2-4. Because of reluctance to attempt epidural placement near the site of the existing intrathecal catheter it was decided toprocede with a continuous caudal technique. Programmation of the intrathecal pump was not changed in the perioperativeperiod.
After induction of general anesthesia and endotracheal intubation, the patient was postioned in the left lateral
decubitus position. The lumbosacral area was prepared with chlorhexidine and draped in a sterile fashion. The skin overlyingthe sacral hiatus was pierced with an 18g needle and an 18g Jelco cathlon was introduced into the caudal space by loss ofresistance. Styletted epidural catheters are not available in our institution, therefore, a 20g Braun epidural catheter wasthreaded through the cathlon to a predetermined distance of 12cm. Aspiration of the catheter was negative for CSF and blood,and a 3mL test dose of Bupivacaine 0.25% and epinephrine 5mcg/mL did not result in tachycardia or ECG changes. Anepidurogram was performed with Omnipaque 180, 0.5mL, revealing distribution of the contrast agent in the epidural space atthe level of L3-4 (Figure 1). The catheter was fixed with Mastisol, steri-strips, and a clear dressing, and a plastic barrier drapewas placed to isolate the catheter insertion site from the buttock area.
An initial bolus dose of 7mL of Bupivacaine 0.25% and epinephrine 5mcg/mL was given, followed by an infusion
of Bupivacaine 0.125% with epinephrine 2.5mcg/mL and Fentanyl 2.5mcg/mL at a variable rate of 7 to 9 mL/hr. Surgicaltime was approximately 6 hours. Upon completion of the procedure the patient was placed in a spica cast. The patient wastransferred to the recovery room and extubated shortly after arrival. He continued on an epidural infusion of Bupivacaine0.07% with Fentanyl 2.5mcg/mL at 7mL/hr and appeared comfortable.
The Fentanyl was removed from the epidural solution on postoperative day 1 because the patient appeared
comfortable but was noted to hypoventilate at 6 breaths per minute although able to maintain an SpO2 of 98% in room air.
Thereafter the respiratory rate was noted to increase to 12 breaths per minute. The patient continued to appear comfortable,with no apparent nausea, vomiting, sedation, motor block, muscle spasms, or local or systemic signs of infection. He wasable to tolerate physical manipulation and mobilization, and able to tolerate gavage feeds. On postoperative day 4 the patientwas converted to analgesia given by his gastrostomy tube and the epidural catheter was removed. There were no signs oflocal infection noted at the catheter site. The remainder of his course was unremarkable and he was discharged home onpostoperative day 8.
Discussion: Patients with cerebral palsy and spasticity significant enough to eventually require intrathecal Baclofen are alsomore likely to present for extensive orthopedic surgery. They also frequently have multiple comorbidities, particularlyrespiratory and gastrointestinal, and communication difficulties can make pain assessment challenging. Large doses ofopioids or the need for benzodiazepines to control muscle spasm may cause significant side effects, including respiratorydepression, nausea, vomiting, and increased risk of aspiration in patients with dysphagia and gastroesophageal reflux. Suchpatients could benefit greatly from regional anesthesia. However, damage to an intrathecal catheter or infection involving theapparatus could be catastrophic. This combination of factors creates a dilemma in how best to manage perioperative pain inthis population.
There are no case reports in the literature describing the use of caudal epidural analgesia for patients with an
implanted intrathecal Baclofen pump. The use of thoracolumbar epidural analgesia in a somewhat older patient in similarcircumstances but less impaired has been recently reported (3). The epidural catheter was inserted above the previous surgicalscar and two vertebral interspaces above the known site of catheter entry into the intrathecal space. Lumbar epiduralanalgesia for labor has also been described in a patient with an intrathecal pump for administration of Morphine to treatintractable epigastric pain secondary to hereditary pancreatitis (4). The epidural catheter was placed below the level of theprevious surgical scar, but no comment was made on whether the entry site of the catheter into the intrathecal space had beenverified from pre-pregnancy radiographs. The technique was successful, albeit difficult, as a midline approach failed, and thefirst paramedian approach resulted in a dural puncture. The only other epidural techniques reported in patients withintrathecal catheters include three case reports of epidural blood patches performed to treat postdural puncture headaches inpatients at time intervals up to 5 weeks after placement of the intrathecal catheter (5,6,7). Two approaches were lumbar, bothperformed one interspace below the level of the intrathecal catheter. One was performed with the aid of fluoroscopy. Thethird report used a caudal approach.
The advantages of caudal versus direct thoracolumbar epidural catheter placement include technically simplicity,
placement of the insertion site remote from the intrathecal catheter insertion site, and likely lower risk of accidental duralpuncture with possible effects on the intrathecal or epidurally-administered drug. Disadvantages include the feasibility ofthreading a caudal catheter cephalad to the desired level in patients of increasing age, and greater potential for contaminationof the caudal catheter insertion site due to its proximity to the buttock area.
This case report described the successful placement of a mid-lumbar epidural catheter by the caudal route in a 29kg,
8 year-old patient, providing excellent quality of analgesia with few side effects. There was no clinically apparent effect ofthe intrathecal infusion on the epidural local anesthetic dose or volume requirements or vice-versa. However, prudence iswarranted with epidural narcotics and as in this case, local anesthetic-only solutions may be sufficient. With strict aseptictechnique, efforts to isolate the caudal catheter from contamination and close postoperative follow-up, infectiouscomplications seem avoidable.
In conclusion, it appears that continuous caudal epidural analgesia can be successfully and safely performed in
patients with an indwelling intrathecal catheter and subcutaneous pump. Preoperative radiographs should be reviewed toconfirm the vertebral level of the intrathecal cathether prior to attempts at epidural catheter placement. The caudal route toepidural placement may offer advantages in simplicity of technique and less potential risk of complications during catheterplacement, provided all measures are taken to minimize the risk of contamination of the catheter. Whether the technique cansucceed in patients older than presented here remains to be evaluated.
References:1. Lyew, M.A. et al., Anesthesiology, 20032. Nolan, J. et al., Anaesthesia, 20003. Piper, N.A. et al., Pediatric Anesthesia, 20064. Tarshis, J. et al., Can J Anaesth, 19975. Sanders, J.C. et al., Anesth Analg, 20046. Huch, K. et al., Spinal Cord, 19997. Robins, B. and Boggs, D.P., Anesth Analg, 2001
Volume 10 • Supplement 1 • 2005 H E L I C O B A C T E R Helicobacter pylori and Non-malignant Diseases Limas Kupcinskas* and Peter Malfertheiner†*Department of Gastroenterology, Kaunas University of Medicine, Kaunas, Lithuania; †Otto-von-Guericke-Universität, Magdeburg, Zentrum für Innere Medizin, Klinik für Gastroenterologie, Hepatologie und Infectiologie, Magdeburg, Germany
¶¶ 3-7) Connections with language ¶ 3) A proper name is any letter or sign or combination of signs that designates ¶¶ 1-2) Sense v. reference ¶ 1ss1-3) Is equality a relation ¶ 4) Grasp of the sense of the name attends understanding of the language. Grasp of the sense illuminates an aspect of the reference (if a reference exists).3Comprehensive knowledge of the reference would all