Date: July 18, 2011 13:46:39 +0700
From: ICVP Secretariat <[email protected]>
Reply-to: ICVP Secretariat <[email protected]>
To: <[email protected]>
Subject: Abstract Submitted - [email protected]
2nd International Congress of Veterinary Pharmacology With many thanks,
This is to acknowledge the receipt of your submitted abstract. You will be advised
of the review process as soon as possible.

*Drug Resistances*
Your Abstract Number: ICVP-1131
Antifungal Activity of Griseofulvin and Flluconazole Against Microsporum
Vitro Model
Nowrozi, H. * 1; Kazemi, A .2; Tohidi Moghaddam, M. 3; Anisian, A. 4 Zar
Department of medical mycology, Tehran University of Medical Sciences, Tehran, Iran pharmacology, Science and Research Branch, Islamic Azad University, Tehran, Iran; pathology, Science and Research Branch, Islamicc Azad University, Tehran, Iran; 4- DoMedicine, Graduated of Veterinary Medicine, Islamic Azad University, Karaj Branch , veterinary Medicine (DVM) and Department of pharmacology, Natures’ gift Corresponding author's email: [email protected]
Objectives: Tinea Capitis (TC) is a current fungal disease in prepubertal children which caused
dermatophytes such as Microsporum and Trichophyton. Griseofulv
recent years, because of excess exposure of this drug, resistance haas reported .So, this study wasantifungal activity of griseofulvin and fluconazole against Microsporum sp in a new In Vitro Mo Materials & Methods: This study was done in two levels (initial and final minimum inhibitory
4 Microsporum strains were supplied from department of mycology of Tehran University of
cultured on sabouraud dextrose agar (SDA) at 30 c .Fungal suspensions were spectrophotometrically supplied wranged .05 – 5 ×10 4 . Initial MICs were done in accordance with National Committee for Clinical LabStandards (NCCLS) guideline. Griseofulvin and fluconazole were supplied 10 two-fold serially diluted rang0.125 -64 µg ml -1 and 0.187 -96 µg ml -1 respectively and incubated with diluted fungal suspensions with RPM Results & Conclusion: The mean initial MICs were 32 µg ml -1 and 48 µg ml -1 for griseofulvin and fluc
respectively. The mean final MICs were 64 µg ml -1 and 96 µg ml -1 for griseofulvin and fluconazole respe
With regard to increase in final MICs and mimic of clinical condition, clinicians should utilize MICs for hiring t
effective antifungal agents for treatment of fungal diseases and prevention of any drug resistance.
Keywords: Microsporum, Griseofulvin, Fluconazole, minimum inhibitory concentration

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