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Nwu.ac.za

Curriculum Vitae of Prof Brian Harvey
SA Pharmacy Council (You can use abbreviations) Faculty of Health Sciences: School of Pharmacy Internal mail box 16, Private bag X6001, Potchefstroom South Africa, 2520 Division of Pharmacology, School of Pharmacy North-West University (NWU) Potchefstroom Campus (PUK) Hoffman street Potchefstroom 2520 3. Qualifications (Start with most recent) Potchefstroom University for CHE (PUCHE) 4. Employment history (From current backwards. Not more than five) and co-director, MRC Unit on North-West University (NWU) Anxiety and Stress Disorders Molecular and cell biology, Behavioural neuroscience, Psychopharmacology 6. Publications (List publications over the last five years) Korff S, Stein DJ, Harvey BH (2009). Cortico-striatal cyclic AMP- phosphodiesterase-4 signalling and stereotypy in the deer mouse: Attenuation after chronic fluoxetine treatment. Pharmacology Biochemistry and Behavior 92: 514-520. Hamlyn E, Brand L, Shahid M, Harvey BH (2009). The ampakine, Org 26576, bolsters early spatial reference memory and retrieval in the 5-day Morris water maze task: A dose-ranging study in rats. Behavioural Pharmacology 20: 662-776. Wegener G, Harvey BH, Bonefeld B, Müller HK, Volke V, Overstreet DH, Elfving B (2010). Stress Associated Changes in the Nitric Oxide Signaling Cascade in a Genetic Animal Model of Depression. International Journal of Neuropsychopharmacology 13: 461-73. Toua C, Brand L, Mőller M, Emsley RA, Harvey BH (2010). The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical NMDA and D1 receptor binding in rats. Neuroscience 165: 492-9. Liebenberg N, Wegener G, Harvey BH, Brink CB (2010). Investigating the role of protein kinase-G in the antidepressant- like response of sildenafil in combination with muscarinic acetylcholine receptor antagonism. Behavioural Brain Research 209: 137-41. Liebenberg N, Harvey BH, Brand L, Brink CB (2010). Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression. Behavioural Pharmacology 21: 540-547. Mokoena ML, Harvey BH, Oliver DW, Brink CB (2010). Ozone modulates the effects of imipramine on immobility in the forced swim test, and nonspecific parameters of hippocampal oxidative stress in the rat. Metabolic Brain Disease 25: 125-33. Harvey BH, Duvenhage I, Viljoen F, Taljaard N, Malan SF, Wegener G, Brink CB, Petzer JP (2010). Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues. Biochemical Pharmacology. Abildgaard A, Solskov L, Volke V, Harvey BH, Lund S, Wegener G (2010). A high-fat diet exacerbates depressive-like behavior in the FSL rat model of depression. Psychoneuroendorinology. Moller M, Du Preez JL, Emsley R, Harvey BH (2010). Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration. Eur Neuropsychopharmacology. Terre’Blanche G, Heyer N, Bergh JJ, Mienie LJ, van der Schyf CJ,,Harvey BH (2010). Behavioral and neurochemical evidence for striatal toxicity in rats treated with phenylglyoxylic acid, a metabolite of styrene. Neurotoxicity Research (submitted). Brand L, Minnaar EL, van Zyl J, Wegener G, Harvey BH (2010). Bidirectional changes in cortico-hippocampal acetylcholine levels and reduced nitric oxide-cGMP signaling in the Flinders Sensitive Line (FSL) rat. Journal of Neurochemistry (submitted). Güldenpfennig M, Wolmarans D, du Preez JL, Stein DJ, Harvey BH (2010). Cortico-striatal oxidative stress, dopamine turnover and relation with stereotypy in the deer mouse. Physiology and Behavior (submitted). Terre’Blanche G, Heyer N, Bergh JJ, Mienie LJ, van der Schyf CJ,,Harvey BH (2011). The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: Influence of dose escalation/reduction over time. Neurotoxicity Research 20:97-101. Liebenberg N, Müller HK, Fischer CW, Harvey BH, Brink CB, Elfving B, Wegener G (2011). An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats. Neuroscience Letters 498:158-61. Hamer M, Malan NT, Harvey BH, Malan L (2011). Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function. Physiology and Behavior 104 (2011) 744–748. Swanepoel T, Harvey BH, Harden LM, Laburn HP, Mitchell D (2011). Dissociation between learning and memory impairment and other sickness behaviours in rats given fibroblast-stimulating lipopeptide-1 (FSL-1). Brain Behavior and Immunity 25:1607-1616. Swanepoel T, Harvey BH, Harden LM, Laburn HP, Mitchell D (2012). Simulated recurrent Mycoplasma infection in rats induces recurrent sickness responses without residual impairment in spatial learning and memory. Physiology and Behaviour 105: 800–808. Harvey BH, Shahid M (2012). Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: Focus on pharmacology and preclinical translational models. Pharmacology Biochemistry and Behavior 100:775-800. Hamer M, Frasure-Smith N, Lespérance F, Harvey BH, Malan NT, Malan L (2012). Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study. International Journal of Hypertension 2012;2012:426803. Malan L, Hamer M, Schlaich MP, Lambert GW, Ziemssen T, Reimann M, Van Rooyen JM, Schutte R, Schutte AE, Fourie CMT, Harvey BH, De Geus JCN, Seedat YK, Malan NT (2012). Facilitated defensive coping, silent ischemia and ECG left ventricular hypertrophy: the SABPA Study. Journal of Hypertension 30:543-550. Petzer A, Harvey BH, Wegener G, Petzer JP (2012). Azure B, a metabolite of methylene blue, is a high-potency, non-selective and reversible inhibitor of monoamine oxidase. Toxicology and Applied Pharmacology 258:403–409. Moller M, Du Preez JL, Emsley RA, Harvey BH (2012). Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment. Neuropharmacology 62: 2499-2506. Moller M, Du Preez JL, Harvey BH (2012). Development and validation of a single analytical method for the determination of tryptophan and its kynurenine metabolites in rat plasma. Journal of Chromatography B 898: 121-129. Liebenberg N, Harvey BH, Brand L, Wegener G, Brink CB. (2012). Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats. Metabolic Brain Disease 27:337–340. Brand L, van Zyl J, Minnaar EL, Viljoen F, du Preez JL, Wegener G, Harvey BH (2012). Cortico-limbic changes in acetylcholine and cGMP in the Flinders Sensitive Line rat, a genetic model of depression. Acta Neuropsychiatrica 24: 215–225. Trabace L, Zotti M, Colaianna M, Morgese MG, Schiavone S, Tucci P, Wegener G, Harvey BH, Cuomo V (2012). Neurochemical differences in two rat strains exposed to social isolation rearing. Acta Neuropsychiatrica 24: 286-295. Harvey BH, Hamer M, Louw R, van der Westhuizen FH, Malan L (2013). Metabolic and glutathione redox markers associated with brain-derived neurotrophic factor in depressed African men and women. Evidence for counter-regulation? Neuropsychobiology 67:33-40. Emsley R, Chiliza B, Asmal L, Harvey BH (2013). The nature of relapse in schizophrenia. BMC Psychiatry Feb 8;13(1):50. Moller M, Du Preez JL, Emsley RA, Harvey BH (2013). Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioral deficits in rats, and is reversed by clozapine or N- acetylcysteine. Brain Behavior and Immunity 30: 156-167. Mashele N, Malan L, van Rooyen JM, Harvey BH, Potgieter JC, Hamer M (2013). Depression, cardiometabolic function and left ventricular hypertrophy in African men and women: The SABPA Study. Clinical and Experimental Hypertension 35: 213-9. Wolmarans D, Brand L, Stein DJ, Harvey BH (2013). Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): Response to chronic escitalopram treatment and basal serotonin transporter (SERT) density. Behavioral Brain Research 256: 545-553. Möller M, Du Preez JL, Viljoen FP, Berk M, Harvey BH (2013). N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats. Metabolic Brain Disease (in press). Petzer A, Harvey BH, Petzer JP (2013). The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase. Toxicology and Applied Pharmacology (in press). Mashele N, Malan L, van Rooyen JM, Harvey BH, Potgieter JC (2013). Blunted neuro-endocrine responses linking depressive symptoms and ECG left ventricular hypertrophy in black Africans: the SABPA study. Cardiovascular Endocrinology (in press). Davis J, Moylan S, Harvey BH, Maes M, Berk M (2013). Neuroprogression in schizophrenia: Pathways underpinning clinical staging and therapeutic corollaries. Australian and New Zealand Journal of Psychiatry (submitted). Strauss L, Brink CB, Stein DJ, Harvey BH (2013). Late-life effects of chronic methamphetamine exposure during puberty on behaviour and cortico-striatal monoamines in social and isolation reared rats. Developmental Neuroscience (submitted). Slabbert N, Harvey BH, Brink CB, Lubbe M (2013). Prospective analysis of the Medicine Possession Rate (MPR) of antidepressants in the private health sector of South Africa (2006 to 2011). Pharmacoepidemiology and Drug Safety (submitted). Slabbert FN, Harvey BH (2013). Understanding antidepressant discontinuation syndrome: Lessons learned with agomelatine. (in preparation). Möller M, Brand S, Harvey BH (2013). Biomarkers in mood and psychotic disorders: Evaluation of the preclinical and clinical evidence. Curr Neuropharmacology (in preparation). Smith AJ, Malan L, Uys L, Ziemssen T, Harvey BH, Malan NT (2013). Down-regulated brain-derived neurotrophic factor (BDNF) is a cardiometabolic risk in Black Africans: The SABPA Study. (in preparation). Mokoena L, Harvey BH, Viljoen F, Brink CB (2013). Effects of chronic ozone inhalation on anxiety- and depression related behavior and markers of oxidative stress in a genetic animal model of depression, and response to antidepressant treatment. Free Radicles in Biology and Medicine (in preparation). 7. Papers delivered (List papers over the last five years) 9th World Congress of Biological Psychiatry, Paris, 28 June – 2 July 2009. Chaired an academic session, entitled “Glutamate as a neurobiological target in anxiety disorders: Metabotropic or ionotropic receptors?”, BH Harvey. 9th World Congress of Biological Psychiatry, 28 June - 2 July 2009, Paris, France. Stress-associated changes in the nitric oxide signaling cascade in a genetic animal model of depression. Wegener G, Harvey B, Elfing B, Muller H, Volke V. 9th World Congress of Biological Psychiatry, 28 June - 2 July 2009, Paris, France. Invited to co-chair a “free communication” session on pre-clinical research in anxiety disorders. 41st Brazilian Congress on Pharmacology and Therapeutic Studies. Presenting an invited plenary talk entitled “Studying the neurobiology of post-traumatic stress disorder using time- dependent sensitisation” at a symposium on “New Developments in PTSD”, Ribeirao Preto Convention Center, Ribeirao Preto, Sao Paulo, Brazil, 17-20 October 2009. Poster presentation at the 3rd International Symposium on Physiology and Pharmacology of Temperature Regulation (PPTR) held in Matsue, Japan, from July 23 (Thu) to 26 (Sun), 2009, entitled “Effects of simulated recurrent mycoplasma infection on fever, growth and learning and memory”, Swanepoel T, Harden LM, Harvey BH, Mitchell D. Poster presentation at the 36th International Congress of the International Union of Physiological Sciences (IUPS), held in Kyoto, Japan from July 27 to August 1, 2009, entitled “Effects of simulated recurrent mycoplasma infection on fever, growth and learning and memory”, Swanepoel T, Harden LM, Harvey BH, Mitchell D. Invited presentation at a symposium on the Biomedical Pathophysiology Relevant to Stress and Disease, entitled “Possible Resilience and Susceptibility Factors Related to Oxidative Stress and the Development of Depression in Male and Female Black Africans: The SABPA study. Harvey BH, Malan L, Hamer, M, Potgieter JC, Schutte AE, Schutte R, Huisman HW, Van Rooyen JM, Fourie CMT. 68th Annual meeting of the American Psychosomatic Society, Maritime Hotel, Portland, Oregon, USA. 11-13 March 2010. Invited research report presented at the Agomelatine Master Class Symposium hosted by Servier Pharmaceuticals, 10-13th February 2010, Paris, France, entitled “Antidepressant discontinuation and the benefits of agomelatine”. Harvey BH. 27th College Internasionale Neuropsychpharmacologicum Congress, Hong Kong, China, 06-10 June 2010. Monoamine oxidase-A inhibition by methylene blue and selected analogues and antidepressant effects in the rat forced swim test. Harvey BH, Duvenhage I, Petzer JP, Malan SF, Wegener G. International Anxiety Disorders Symposium, Spier Estate, Cape Town, South Africa, 1-2 May 2010. Stereotypy in the deer mouse: Correlation with cortico-striatal oxidative status and dopamine turnover, and response to combined fluoxetine/risperidone treatment. Güldenpfennig M, du Preez JL, Wolmarans D, Stein DJ, Harvey BH. Best Poster Award. International Union of Pharmacology World Pharma Congress, Copenhagen, Denmark, 17-23 July 2010. Cholinergic and glutamate-nitric oxide signaling pathways in a genetic animal model of depression, the Flinders Sensitive Line (FSL) rat. Brand L, Minnaar EL, van Zyl J, Wegener G, Harvey BH. 10th World Congress of Biological Psychiatry, 29 May – 2 June 2011, Prague, Czech Republic. Endogenous markers of nitric oxide in plasma of the Flinders sensitive line (FSL) rat, a genetic animal model of depression. Brand L, Watson M, Viljoen FP, Harvey BH. Anxiety and Depression: 21st Neuropharmacology Conference, 10-11 November 2011, Westin Tyson’s Corner, Tyson’s Corner, Virginia, USA (Satellite meeting of the 2011 Society for Neuroscience Congress, Washington, USA). Isolation Rearing Alters Plasma Tryptophan Metabolism in Rats and Decreases the Neuroprotective Ratio: Reversal by Clozapine. Moller M, Du Preez JL, Harvey BH. 3rd Schizophrenia International Research Society Conference, 14-18 April 2012, Florence, Italy. Social isolation rearing in rats induces schizophrenia-like behaviours that are reversed by sub-chronic treatment with clozapine or N-acetyl cycteine. Moller M, Emsley. R, Harvey BH. 3rd Schizophrenia International Research Society Conference, 14-18 April 2012, Florence, Italy. Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment. Moller M, Du Preez JL, Harvey BH. African Congress of Pharmacology, La Palm Hotel, Accra, Ghana, 11-13th July 2012. Invited plenary speaker. Using animal models to advance our understanding of anxiety and stress-related disorders. Harvey BH. African Congress of Pharmacology, La Palm Hotel, Accra, Ghana, 11-13th July 2012. Chronic Ozone Exposure Induces Oxidative Stress in Stress-sensitive Rats: Association with Memory Impairment and Depressogenic and Anxiogenic Effects. Mokoena M, Brink CB, Oliver DW, Harvey BH. Experimental Biology Congress 2013, Boston, MA, USA, 20-14 April 2013. Chronic Ozone Exposure Induces Oxidative Stress in Stress-sensitive Rats: Association with Memory Impairment and Depressogenic and Anxiogenic Effects. Mokoena ML, Brink CB, Oliver DW, Harvey BH. Invited by the organisers of 11th World Congress of Biological Psychiatry, held in Kyoto, Japan, 23-27 June 2013, to chair a symposium entitled “Novel approaches for the treatment of unipolar depression”, as wel as to present a talk on “N-acetyl cysteine as a novel treatment for depression”. 11th World Congress of Biological Psychiatry, Kyoto, Japan, 23-27 June 2013. Social isolation rearing induces a pro-inflammatory state in rats with associated mitochondrial, neurochemical and behavioural deficits: Reversal by Clozapine or N-acetylcysteine. Harvey BH, Möller M, Du Preez JL. Fifth International Conference on Pharmaceutical and Pharmacological Sciences ICPPS), 23-26 September 2009, Potchefstroom, North-West Province, South Africa. The effect of isolation rearing on schizophrenia-like behaviours and corticostriatal parameters of oxidative stress in rats, and response to clozapine. Moller M, du Preez JL, Emsley RA, Harvey BH. Fifth International Conference on Pharmaceutical and Pharmacological Sciences ICPPS), 23-26 September 2009, Potchefstroom, North-West Province, South Africa. The structure activity relationship of methylene blue and its analogues as lead compounds for novel antidepressant drug development. Duvenhage I, Petzer JP, Wegener G, Malan SF, Harvey BH. Fifth International Conference on Pharmaceutical and Pharmaco-logical Sciences ICPPS), 23-26 September 2009, Potchefstroom, North-West Province, South Africa. Stereotypy in the deer mouse, correlation with cortico-striatal oxidative stress and dopamine turnover, and response to combined fluoxetine/risperidone treatment. Guldenpfennig M, du Preez JL, Wolmarans D, Stein DJ, Harvey BH. Fifth International Conference on Pharmaceutical and Pharmacological Sciences ICPPS), 23-26 September 2009, Potchefstroom, North-West Province, South Africa. Basal versus KCl-evoked frontal cortical glutamate release in Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats: An in vivo microdialysis study. Visser G, Brand L, du Preez JL, Wegener G, Viljoen FP, Harvey BH. Fifth International Conference on Pharmaceutical and Pharmacological Sciences ICPPS), 23-26 September 2009, Potchefstroom, North-West Province, South Africa. Time- dependent sensitization as a behavioral model for investigating the neurobiology of post-traumatic stress disorder. Harvey BH. South African Biological Psychiatry Congress, Arabella, Western Cape, South Africa, 28-31 May 2009. Cholinergic, GABA and glutamate-nitric oxide signalling in a genetic rodent model of depression, the Flinders Line Sensitive (FSL) rat. Brand L, Minnaar EL, van Zyl J, Harvey BH. South African Biological Psychiatry Congress, Arabella, Western Cape, South Africa, 28-31 May 2009. Animal models of depression: Foolish reductionism of reliable science ? Brink CB, Brand L, Harvey BH South African Biological Psychiatry Congress, Arabella, Western Cape, South Africa, 28-31 May 2009. Invited plenary speaker. Major depression and metabolic encephalopathy: Syndromes more alike than not? Harvey BH South African Biological Psychiatry Congress, Arabella, Western Cape, South Africa, 28-31 May 2009. Increased glutamate NMDA-nitric oxide signaling following stress in the Flinders (FSL/FRL) rat implicates nitric oxide as a vulnerability factor in depression. Harvey BH. Wegener G, Bonefeld B, Müller HK, Volke V, Overstreet DH, Elfving B South African Biological Psychiatry Congress, Arabella, Western Cape, South Africa, 28-31 May 2009. Investigating the pro- cogni-tive actions of the AMPA receptor positive allosteric modulator, Org 26576, during spatial reference memory acquisition and retrieval in rats. Harvey BH, Hamlyn E, Brand L, Shahid M South African Biological Psychiatry Congress, Arabella, Western Cape, South Africa, 28-31 May 2009. Frontal cortical NMDA/D1 receptor binding following isolation rearing in rats, and differential response to sub-chronic clozapine and haloperidol treatment. Harvey BH, Toua C, Brand L, Mől er M, Emsley RA South African Biological Psychiatry Congress, Arabella, Western Cape, South Africa, 28-31 May 2009. Animal models of obsessive compulsive disorder: Where are we and where are we going? Wolmarans D, Stein DJ, Harvey BH. South African Congress for Pharmacology and Toxicology, Cape Town Lodge Hotel, Cape Town, South Africa, 3-6 October 2010. Behavioral and neurochemical evidence for striatal toxicity in rats treated with phenylglyoxylic acid, a metabolite of styrene. Terre’Blanche G, Heyer N, Bergh JJ, Mienie LJ, van der Schyff CJ, Harvey BH. Award for Best Poster. South African Congress for Pharmacology and Toxicology, Cape Town Lodge Hotel, Cape Town, South Africa, 3-6 October 2010. The effects of sildenafil, with and without atropine, on anxiety-like behavior in rats and on the expression of phosphodiesterase type 5 in rat brain. Slabbert FN, Brink CB, Harvey BH. South African Congress for Pharmacology and Toxicology, Cape Town Lodge Hotel, Cape Town, South Africa, 3-6 October 2010. Decreased plasma nitrite (NO2-) levels in a genetic rat model of depression, the Flinders Sensitive Line (FSL) rat: A possible biomarker of depression? Watson M, Brand L, Viljoen FP, Harvey BH. Winner of the South African Society for Basic and Clinical Pharmacology “Young Scientists Award, 2010” for the best podium presentation by an M.Sc student (M Watson). South African Congress for Pharmacology and Toxicology, Cape Town Lodge Hotel, Cape Town, South Africa, 3-6 October 2010. Phosphodiesterase type 5 inhibitors as novel antidepressant strategy: A review of the evidence. Brink CB, Harvey BH. South African Congress for Pharmacology and Toxicology, Cape Town Lodge Hotel, Cape Town, South Africa, 3-6 October 2010. Phosphodoesterase type 5 inhibitors enhance DNA repair capacity in neuroblastoma (SH-SY5Y) cells by enhancing cGMP/protein kinase G signaling. Reay R, van Niekerk BPJ, Harvey BH, Brink CB. Sixth International Conference on Pharmaceutical and Pharmaco-logical Sciences ICPPS), 25-27 September 2011, Coastlands Ho-tel Umhlanga, Durban. Natural Stereotypy in Deer Mice and its Association With Frontal Cortical and Striatal Serotonin Transpor-ter (SERT) Density. Wolmarans D, Brand L, Stein DJ, Harvey BH. Sixth International Conference on Pharmaceutical and Pharmaco-logical Sciences ICPPS), 25-27 September 2011, Coastlands Hotel Umhlanga, Durban. An Investigation into the Role of Noradrenergic Receptors in Conditioned Fear: Relevance to Posttraumatic Stress Disorder (PTSD). Erasmus M, Harvey BH. Sixth International Conference on Pharmaceutical and Pharmacological Sciences ICPPS), 25-27 September 2011, Coastlands Hotel Umhlanga, Durban. Role of the Peroxisome Proliferator Activated Receptor (PPAR)-γ Pathway in Mood Regulation and Antidepressant Action. Brand SJ, Brink CB, Wegener G, Harvey BH. Sixth International Conference on Pharmaceutical and Pharmaco-logical Sciences ICPPS), 25-27 September 2011, Coastlands Hotel Umhlanga, Durban. Effect of Early-Life Exposure to the Serotonin-Norepinephrine Reuptake Inhibitor, Venlafaxine, on Behaviour in Adulthood in Stress-Sensitive Rats. Steyn SF, Harvey BH, Brink CB. Winner of the South African Society for Basic and Clinical Pharmacology “Young Scientists Award, 2011” for the best podium presentation by an M.Sc student (SF Steyn). Sixth International Conference on Pharmaceutical and Pharmacological Sciences ICPPS), 25-27 September 2011, Coastlands Hotel Umhlanga, Durban. A single analytical method for the determination of tryptophan, and five of its metabolites in rat plasma. Moller M, Du Preez JL, Harvey BH (SASBCP Best Poster Award). Sixth International Conference on Pharmaceutical and Pharmacological Sciences ICPPS), 25-27 September 2011, Coastlands Hotel Umhlanga, Durban. Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment. Moller M, Du Preez JL, Harvey BH. Sixth International Conference on Pharmaceutical and Pharmacological Sciences ICPPS), 25-27 September 2011, Coastlands Hotel Umhlanga, Durban. Ozone-induced oxidative stress is associated with a depressogenic effect in stress sensitive rats. Mokoena, M, Brink CB, Oliver DW, Harvey BH. Biological Psychiatry Congress, 22-25 September 2011, Protea Hotel, Stellenbosch, South Africa. Neurochemical, peripheral and behavioural effects of social isolation rearing in rats: Relevance for schizophrenia. Möller M, Emsley R, Harvey BH. Congress of the South African Society for Basic and Clinical Pharmacology, University of Pretoria, Pretoria, South Africa, 29 Sept-2 October 2012. Effects of early life exposure of metamphetamine on depressive-like behavior in stress-sensitive rats. Swart C, Harvey BH, Stein DJ, Brink CB. Effects of chronic metamphetamine exposure during puberty on late-life social interactive and sensorimotor gating behaviors in social and isolation reared rats. Congress of the South African Society for Basic and Clinical Pharmacology, University of Pretoria, Pretoria, South Africa, 29 Sept-2 October 2012. Strauss L, Brink CB, Stein DJ, Harvey BH, Recipient of the Best Young Scientist Award (shared with M Moller). Social isolation rearing induces a pro-inflammatory state in rats withy associated deficits in sensorimotor gating, and is reversed by clozapine or N-acetyl cysteine. Congress of the South African Society for Basic and Clinical Pharmacology, University of Pretoria, Pretoria, South Africa, 29 Sept-2 October 2012. Moller, M, du Preez J, Harvey, BH. Recipient of the Best Young Scientist Award (shared with L Strauss). Depressive symptoms in black South Africans demonstrate gender-based differences in its association with serum levels of brain derived neurotrophic factor and markers of metabolic and oxidative stress. Congress of the South African Society for Basic and Clinical Pharmacology, University of Pretoria, Pretoria, South Africa, 29 Sept-2 October 2012. Harvey BH.

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Potential Effect of a Low-Fat, Vegan Diet on Medication Costs in Type 2 Diabetes Diabetes treatment typical y involves the use of several pharmaceutical agents. Often, one, two, or more drugs are required for blood glucose control, along with additional agents to reduce blood cholesterol and blood pressure. While drug treatments are often necessary and can be lifesaving, their use ent

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