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Os-cr kc-3 metformin hydrochloride 500 mg extended release tablets

Metformin Hydrochloride 500 mg Extended Release Tablet s
This formulation features Metformin Hydrochloride 500 mg tablets developed with Carbopol®* 974P NF polymer and hypromellose as the
Tablet Properties
2. Carbopol® 974P NF Polymer
Dissolution/Drug Release** 1 hour: 32 - 35% 5. Hypromellose Substitution Type 2208 USP ** USP Apparatus 1, 100 rpm, 900 ml pH 6.8 buf er Procedure
Metolose® is a registered trademark of Shin-Etsu Chemical Co., Ltd. 1. Weigh Metformin HCl, Carbopol® 974P NF polymer and hypromellose and pass through a
60 mesh sieve. Add the ingredients to a planetary mixer (or a high shear granulator) and blend for 5 minutes at slow speed (20 rpm). Granulate with isopropyl alcohol (~330 ml for a 1,000 tablet batch ) added over a period of 2 minutes while mixing at medium speed (50 rpm). Continue mixing for about 3 minutes or until the isopropyl alcohol has been 2. Pass the wet mass through a 3 mm screen. Dry the resulting granules on trays without heating for about 30 minutes to allow the isopropyl alcohol to evaporate. Continue drying at 65°C to a moisture content of less than 2%. 3. Pass the granules through a 20 mesh sieve and blend them with hypromellose (60 mesh sieve) for 8 minutes. Add the talc and magnesium stearate (60 mesh sieve) and blend for 2 Punches: 17.10 x 8.20 mm concave, capsule shaped Target weight: 800.0 mg Mechanical strength: 15 kP Friability: NMT 0.5 % w/w (100 revolutions) Previous Editions: December 19, 2008 / November 20, 2009 • Precautions should be taken during manufacture to avoid contact with water. Also, the manufacturing area and equipment must be flame proof as isopropyl alcohol is used for granulation. • The Metformin HCL grade used in this formulation had a specification of not less than 95% passing For more information or to request product samples, please visit orth America
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Noveon is a registered trademark of The Lubrizol Corporation *Trademark owned by The Lubrizol Corporation Copyright 2011 Lubrizol Advanced Materials, Inc.

Source: https://www.lubrizol.com/Life-Science/Documents/Pharmaceutical/Formulations/OS-CR-KC-3-Metformin-Hydrochloride-500-mg-ER-Tablets.pdf

String too short to be saved, 1979, 155 pages, donald hall, david r. godine publisher, 1979, pdf ebook

String Too Short to be Saved, Donald Hall, David R. Godine Publisher, 1979, 087923282X, 9780879232825,155 pages. This is a collection of stories diverse in subject, but sutured together by the limitless affection theauthor holds for the land and the people of New England. Donald Hall tells about life on a small farm where,as a boy, he spent summers with his grandparents. Gradually the boy grows


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