Journal of Microbes and Infection, September 2009, Vol. 4, No. 3 Advances in mechanisms of bacterial resistance to linezolid and
related detection methods

1. No. 263 Hospital of Chinese People s Liberation Army, Beijing 101149, China; 2. Dalian Medical University, Abstract: Linezolid is an antibacterial belonging to the oxazolidinone class of antibiotics. The importance of linezolid
as an antibiotic is related to its activity against a number of clinically significant Gram-positive cocci, including
multidrug-resistant staphylococci and vancomycin-resistant enterococci. Although bacterial resistance to linezolid is not a major issue at present, its development in clinical isolates should be paid more attention. In this article, the mechanisms of bacterial resistance to linezolid, and related detection methods were reviewed. We showed that bacterial resistance is mediated by a single-nucleotide mutation and the production of methyltransferase, however, other potential mechanisms have not yet been determined. The detection methods for linezolid resistance include microbiological and molecular biological methods, some of which would benefit from technological improvements.
Key words: Linezolid; Resistance; Oxazolidinone; Bacteria
( methicillin-resistant Staphylococcus aureus, MRSA) ( vancomycin-resistant enterococci, Corresponding author: XIA Meng-Y an, E-mail: [email protected] 126. com Journal of Microbes and Infection, September 2009, Vol. 4, No. 3 ( chloramphenicol-florfenicol resistance, Journal of Microbes and Infection, September 2009, Vol. 4, No. 3 [ 1] Mutnick AH, Enne V, Jones RN. Linezolid resistance since 2001: Sentry antimicrobial surveillance program [ J] . Ann Pharmacother, 2003, 37( 6) : 769-774 dependence of emergence of resistance to linezolid in Enterococcus faecalis in vivo[ J] . J Infect Dis, 2007, 195 [ 3] Potoski BA, Adams J, Clarke L, et al. Epidemiological Staphylococci[ J] . Clin Infect Dis, 2006, 43( 3) : 165-171 [ 4] Hillemann D, R sch-Gerdes S, Richter E.
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