V e r ö f f e n t l i c h u n g e n P r o f . D r . O l i v e r M ü l l e r 1) Originalpublikationen ab 2005
Chen J, Röcken C, Lofton-Day C, Schulz HU, Müller O, Kutzner N, Malfertheiner P, Ebert M: Molecular analysis of APC promoter methylation and expression in colorectal cancer metastasis. Carcinogenesis 26(1): 37-43 (2005) Kutzner N, Hoffmann I, Linke C, Thienel T, Grzegorczyk M, Urfer W, Martin D, Winde G, Traska T, Hohlbach G, Müller KM, Kuhnen C, Müller O: Non-invasive colorectal cancer diagnosis by the combined application of molecular diagnosis and the faecal occult blood test. Cancer Letters 229: 33-41 (2005) Rosenbaum C, Röhrs S, Müller O, Waldmann H: Modulation of MRP-1-Mediated Multidrug Resistance by Indomethacin Analogues. Journal of Medicinal Chemistry 48(4): 1179-1187 (2005) Ziegler S, Röhrs S, Tickenbrock L, Möröy T, Klein-Hitpass L, Vetter IR, Müller O: Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation. The FEBS Journal 272(7): 1600-1615 (2005) Lehnhardt M, Muehlberger T, Kuhnen C, Brett D, Steinau HU, Joneidi Jafari H, Steinstraesser L, Müller O, Homann HH: Feasibility of Chemosensitivity Testing in Soft Tissue Sarcomas. World Journal of Surgical Oncology 3(20): 1-12 (2005) Fürstner A, Kirk D, Fenster M, Aissa C, De Souza D, Müller O: Diverted Total Synthesis: Preparation of a Focused Library of Latrunculin Analogues and Evaluation of their Actin- Binding Properties. Proc. Nat. Acad. Sci. USA (PNAS) 102(23): 8103-8108 (2005) Lehnhardt M, Klein-Hitpass L, Kuhnen C, Homann HH, Daigeler A, Steinau HU, Röhrs S, Schnorr L, Steinstraesser L, Müller O: Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BioMedCentral Cancer 5: 74-90 (2005) Barun O, Kumar K, Sommer S, Langerak A, Mayer TU, Müller O, Waldmann H: Natural Product Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity. European Journal of Organic Chemistry 22: 4773-4788 (2005) und Cover Picture Becker CFW, Wacker R, Bouschen W, Seidel R, Kolaric B, Lang P, Schroeder H, Müller O, Niemeyer CM, Spengler B, Goody RS, Engelhard M: Protein-DNA Arrays as Tools for Detection of Protein-Protein Interactions by Mass Spectrometry. Angew. Chemie 117: 7808-7812 (2005) und Angew. Chemie Int Edit 44: 7635-7639 (2005) Lumbierres M, Palomo JM, Kragol G, Röhrs S, Müller O, Waldmann H: Solid-Phase Synthesis of Lipidated Peptides. Chemistry 11: 7405-7415 (2005)
Sievers S, Fritzsch C, Grzegorczyk M, Kuhnen C, Müller O: Absolute beta-catenin concentrations in Wnt pathway stimulated and non-stimulated cells. Biomarkers 11 (3): 270-278 (2006) Sievers S, Fritzsch C, Kutzner N, Lehnhardt M, Kuhnen C, Müller O: Hypermethylation of the APC Promoter but lack of APC mutations in Myxoid/Round-cell Liposarcoma. International Journal of Cancer 119: 2347-2352 (2006) Fürstner A, Kirk D, Fenster MDB, Aïssa C, De Souza D, Nevado C, Tuttle T, Thiel W, Müller O: Latrunculin Analogues with Improved Biological Profiles by Diverted Total Synthesis: Preparation, Evaluation and Computational Analysis. Chemistry 13: 135-140 (2007) Ziegler S, Röhrs S, Tickenbrock L, Langerak A, Chud S, Feldmann I, Jakubowski N, Müller O: 24p3 is regulated by the Wnt pathway independently from iron. Cancer Genetics and Cytogenetics 174: 16-23 (2007) Fürstner A, Nagano T, Müller C, Seidel G, Müller O: Total synthesis and evaluation of the actin-binding properties of microcarpalide and a focused library of analogues. Chemistry 13: 1452-1462 (2007) Lessmann T, Leuenberger MG, Menninger S, Lopez-Canet M, Müller O, Hümmer S, Bormann J, Korn K, Fava E, Zerial M, Mayer TU, Waldmann H: Natural Product-derived Modulators of Cell Cycle Progression and Viral Entry by Enantioselective Oxa Diels-Alder Reactions on the Solid Phase. Chemistry & Biology 14(4): 443-451 (2007) Fürstner A, Nevado C, Wasser M, Tremblay M, Chevrier C, Teply F, Aïssa C, Moulin E, Müller O: Total synthesis of Iejimalide A-D and assessment of the remarkable actin-depolymerizing capacity of these polyene macrolides Journal of the American Chemical Society 129(29): 9150-9161 (2007) Köster MP, Müller O, Pollerberg E: Adenomatous Polyposis Coli (APC) is differentially distributed in growth cones and modulates their local stability and steering. Journal of Neuroscience 27(46): 12590-12600 (2007) Wehner F, Nören-Müller A, Müller O, Reis-Correa I, Giannis A, Waldmann H: Indoloquinolizidine Derivatives as Novel and Potent Apoptosis Inducers and Cell-Cycle Blockers. ChemBioChem 9: 401-405 (2008) und Cover Picture Csepregi A, Röcken C, Hoffmann J, Ping G, Saliger S, Müller O, Schneider-Stock R, Kutzner N, Roessner A, Malfertheiner P, Ebert MP: APC promoter methylation and protein expression in hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology 134(5): 579-589 (2008) Sievers S, Fritzsch C, Kuhnen C, Müller O: SPMSP: Solid-phase PCR with colorimetric read-out for quantitative methylation analysis. Anticancer Research 28: 2055-2060 (2008)
Daigeler A, Lehnhardt M, Müller O, Steinau HU, Homann H, Hauser J, Chromik A, Klein- Hitpass L: Heterogeneous in vitro effects of doxorubicin on gene expression in primary liposarcoma cultures. BMC Cancer 8: 313 (2008) Tickenbrock L, Hehn S, Sargin B, Choudhary C, Bäumer N, Bürger H, Schulte B, Müller O, Berdel WE, Müller-Tidow C, Serve H: Activation of Wnt signalling in leukaemia by inducation of Frizzled-4. International Journal of Oncology 33(6): 1215-1221 (2008) Daigeler A, Klein-Hitpass L, Stricker I, Müller O, Kuhnen C, Chromik AM, Steinstraesser L, Goertz O, Steinau HU, Lehnhardt M: Malignant fibrous histiocytoma – pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. Langenbecks Archives of Surgery 394(3): 589-596 (2009) Röhrs S, Kutzner N, Vlad A, Grunwald T, Ziegler S, Müller O: Chronological expression of Wnt target genes Ccnd1, Myc, Cdkn1a, Tfrc, Plf1 and Ramp3. Cell Biology International 33: 501-508 (2009) Marelli MM, Moretti RM, Mai S, Müller O, van Groeninghen J, Limonta P: Novel insights into GnRH receptor activity: Role in the control of human glioblastoma cell proliferation. Oncology reports 21: 1277-1282 (2009) Lanckohr C, Debiec-Richter M, Müller O, Homann H-H, Lehnhardt M, Herter P, Kuhnen C: Gardner fibroma: Case report with morphologic, molecular biological and genetic analysis and discussion of a relatively new soft tissue tumor entity. Der Pathologe: in Druck Götze S, Wolters M, Reifenberger G, Müller O, Sievers S: Promoter hypermethylation of Wnt inhibitors is a frequent event during gliomagenesis. International Journal of Cancer: in Druck 2. Patente
Process for purifying, stabilising or isolating nucleic acids from biological materials Patent PCT / EP 96 / 03595 (1998) A method for purification of DNA from biological materials Patent PCT / EP 98 / 00052 (2000) The interaction of the APC wild-type tumor suppressor protein with DNA and its high nuclear level in proliferating cells as new tools in research and diagnostics – a new method for the detection of fast proliferating cells Patent PCT / EP 00 / 06656 (2000) An assay for the detection of primary DNA lesions based on the interaction of the DNA with DNA repair proteins Patent PCT / EP 01 / 06591 (2001)
A new method for detecting DNA mutations Anmeldung 01 07 317 beim Deutschen Patentamt (2001) Novel Indenyl derivatives with therapeutic implications Anmeldung 01 19 483 beim Deutschen Patentamt (2001) Novel compounds, derived from Sulindac as a lead compound, with anti-proliferative, apoptosis inducing or cell transformation reverting effects, and cell biological assays for measuring these effects Anmeldung 01 63 426 beim Deutschen Patentamt (2001) Method for the analysis of nucleic acid methylation Patent PCT / EP 06 / 009233 (2006) A child-safe device for reversible fixation of standard blisters Utility Patent (Gebrauchsmuster) 06 003 379 beim Deutschen Patentamt (2006) 3. Übersichtsartikel (Reviews), Lehrbuch und Internetseite (ab 2006)
Shahmoradgoli M, Müller O, Kutzner, N, Noorinayer B, Zali MR: Gene Symbol: APC. Disease: Familial adenomatous polyposis coli Human Genetics 118(6): 776 (2006) Linke C, Müller O: Colorectal Cancer Screening: Molecular Diagnosis Encyclopedia of Medical Genomics and Proteomics by Jürgen Fuchs & Maurizio Podda (Editors), Taylor & Francis Books New York 1(1): 1-5 (2007) Röhrs S, Müller O: The Wnt pathway as a target for novel anti-cancer drugs Current Chemical Biology 1: 227-239 (2007) Hauss O, Müller O: The Protein Truncation Test (PTT) in mutation detection and molecular diagnosis Methods in Molecular Biology: In vitro Transcription and Translation Protocols, Second Edition by Guido Grandi (Editor), Humana Press Totowa 375: 151-164 (2007) Vlad A, Röhrs S, Klein-Hitpass L, Müller O: The first five years of the Wnt targetome Cellular Signalling, 20(5): 795-802 (2008) Wagener C, Müller O: Molekulare Onkologie: Entstehung, Progression, klinische Aspekte 3. Auflage, Georg Thieme Verlag Stuttgart (2009) Wagener C, Müller O: http://www.onkoview.com Internet-Seite mit Animationen zur Molekularen Onkologie (2009)
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Premenstrual syndrome (PMS) Overview Premenstrual syndrome (PMS) is a range of physical, psychological and behavioural symptoms that women can suffer up to two weeks before their period begins.1, 2 Doctors are still unsure what causes PMS but it’s been attributed to hormonal change, chemicals called neurotransmitters, hormone-like prostaglandins, diet and lifestyle.2 PMS often increa