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Mehmet TANOL. Ph.D.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir,
Turkey, Ph.D., 1983.
Faculty of Pharmacy, University of Istanbul, Istanbul, Turkey, B.Pharm., 1973 ACADEMIC APPOINTMENTS:
Full Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul Kemerburgaz
University, Istanbul, Turkey, April 2012 to present.
Full Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege Universty, Izmir,
Turkey, April 1999 to August 1999.
Associate Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University,
Izmir, Turkey, October 1992 to April 1999.
Assistant Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University,
Izmir, Turkey, February 1987 to October 1992.
Research Assistant, Faculty of Pharmacy, Ege University, Izmir, Turkey, January 1979 to
Teaching Assistant, Faculty of Pharmacy, Ege University, Izmir, Turkey, October 1973
to January 1979. SABBATICAL LEAVES:
Research Associate, Biotechnology Innoviation & Optimization Center ,University of
Kansas, 2009 to 2012
Research Associate, Center for Drug Delivery Research,University of Kansas, ( Dr. R.
Rajewski), December 1999 to 2009
Post doc., Department of Pharmaceutical Chemistry, University of Kansas, (Dr. J.H.
Rytting), December 1996 to 1999
Post doc., Department of Medicinal Chemistry, University of Kansas, (Dr. J. Aube'),
September 1988 to September 1990. PROFESSIONAL EXPERIENCES:
Pharmacist, registered; July 1972, Bergama, Izmir, Turkey
Pharmacist, registered; July 1971, Bergama, Izmir, Turkey PROFESSIONAL MEMBERSHIPS:
American Chemical Society (February 2002 to present)
American Association of Pharmaceutical Scientists (June 1997 to present)
Organization of Ege University Faculty of Pharmacy Graduates and Affiliates (1996 to
Evaluation Committee for Research Awards granted by Toprak Ilac; A prominent drug
company located in Istanbul, Turkey (1996 to 1997)
Organization of Pharmaceutical and Medicinal Chemistry, Ankara, Turkey (1995 to
Turkish Association of Pharmacists (June 1973 to present)
Associate Professor Representative in the Faculty Council (March 1996 to January 1997)
Undergraduate Level: (Faculty of Pharmacy, Ege University, Izmir, Turkey)
Organic Chemistry (2 credit hours) offered to 2nd year pharmacy students.
Medicinal Chemistry I / II (4 credit hours) offered to 3rd year pharmacy students.
Medicinal Chemistry III / IV (4 credit hours) offered to 4th year pharmacy students. Pharmaceutical Chemistry Practicum I / II offered to 3rd year pharmacy students. Pharmaceutical Chemistry Practicum III / IV offered to 4th year pharmacy students.
Graduate Level: (Faculty of Pharmacy, Ege University, Izmir, Turkey)
Stereochemistry (2 credit hours) offered in the M.S. program
Advanced Organic Chemistry (4 credit hours) offered in the Ph.D. program
QSAR of Drugs (2 credit hours) offered in the Ph.D. program RESEARCH INTERESTS:
Synthesis of Prodrugs (POM , Cyclic Peptides).
Total synthesis of potentially active heterocycles: more recent interest on stereoselective
total synthesis of natural products with pharmacological activity.
Synthesis of new biodegradable transdermal penetration enhancers.
Studies on physicochemical properties of synthesized compounds, leading to SAR and
The preparation of the new enhancers and prodrugs for targeted drug delivery systems.
Structure elucidation of unknown compounds using spectrometric methods.
HPLC, UV, 1H-NMR and 13C-NMR, IR, MS of drug substances.Activity tests and
assays on synthesized compounds (local anesthetic and antispasmodic activity tests).
1H- and 13C-NMR (Bruker WP60, Bruker WP90, Varian 300LX).
IR (Perkin Elmer 577, Perkin Elmer 1420).
UV (Carl Zeiss PMQ, Perkin Elmer Lambda 5) Spectrometers.
LCMS (Shimadzu 2010)
HPLC (Perkin Elmer, Waters).
Polarimeter (Perkin Elmer 241 MC).
Chromatotron (7924 T Harrison Research).
Animal Handling (Local anesthetic activity tests on the skins of guinea pigs and
antispasmodic activity tests on ileum of rats).
Principles of Radiation Safety.
Macintosh and IBM PC computers.
U.S. and Turkish citizen, married, two children. Born in Bergama (August 22,1949),
Auxiliary Activities: Reading, Hunting, Sailing, Swimming, Soccer. PUBLICATIONS:
, "Studies On the Synthesis and structure-activity Relationship of Some p
-Acylaminophenylmorpholinoalkyl Ethers with Potential Local Anesthetic
Activity", Ph.D. Thesis, Izmir, (1983).
, "Studies On Some p
-Acylaminophenylmorpholinoalkyl Ethers", Gazi
Ecz. Fak. Der. 3
(1), 81 (1986).
J. Aube', Y. Wand, M. Hammond, M. Tanol,
F. Takusagawa and D. V. Velde,
"Synthetic Aspects of an Asymmetric Nitrogen Insertion Process: Preparation of
Chiral, Non-Racemic Caprolactams and Valerolactams. Total Synthesis of (-)-
Alloyohimbane", J. Am. Chem. Soc., 112
U. Ucucu, I. Isikdag and M. Tanol
, " Antihelmintic Activity and QSARs of Some
2-Alkyl-5-chlorobenzimidazole Derivates", Gazi Ecz. Fak. Der., 9
P. Ozic, M. Tanol
, M. Cizmecioglu, V. Pabuccuoglu and B. Gozler, "Synthesis of
Some Potentially Active 1-Substitutedaryl-1,2,3,4-tetrahydroisoquinolines via
3,4-Dihydro Analogs", Doga TU J.Pharm., 2
(2), 81 (1994).
J. Aube', S. Ghosh, and M. Tanol
, "Symmetry-Driven Synthesis of Indole
Alkoloids: Asymmetric Total Synthesis of (+)-Yohimbine, (-)-Yohimbone, (-)-
Yohimbane, and (+)-Alloyohimbane", J. Am. Chem. Soc., 116
, 9009 (1994).
S. Ghosh, M. Tanol
and J. Aube', "A Novel Route to the Alkoloids of the
Yohimbine Family"; presented at the 28th Annual Medicinal Chemistry Meeting-
In-Miniature (MIKI), held in the University of Illinois at Chicago, U.S.A. in May
S. Dickey, M. Hammond, M. Tanol
and J. Aube', "Asymmetric Synthesis of
Chiral Glyceral Equivalents", presented within the Seminar Program of the
University of Kansas, School of Pharmacy, Department of Medicinal Chemistry
U.S.A. in September (1990).
T. Buyuktimkin, M. Tanol
, S. Buyuktimkin, N. Buyuktimkin, J. L. Yeager and J.
H. Rytting, " Permeation and Dissapperarance Studies with two Biodegradable
Penetration Enhancers, Dodecyl 2-(N,N-Dimethylamino)-Propionate(DDAIP) and
2-(N,N-Dimethylamino)-Propanol Tetradecanoate(DAIPM) in Shed Snake Skin",
presented at the 12th Annual AAPS Meeting, Abstract 2240.Pharm. Res. 14
, S. Buyuktimkin, N. Buyuktimkin, J. L. Walters, J. L. Yeager and J. H.
Rytting, "Comparison of Model Membranes for Transdermal Studies: Part I.
Transport Study" presented at the 12th Annual AAPS Meeting, Abstract
2295.Pharm. Res. 14
: S 316, (1997).
, S. Buyuktimkin, N. Buyuktimkin, J. L. Walters, A. E. Cohen, J. L.
Yeager and J. H. Rytting, "Comparison of Model Membranes for Transdermal
Studies: Part II. Total Lipid Content and Composition" presented at the 12th
Annual AAPS Meeting, Abstract 2296.Pharm. Res. 14
: S 316, (1997).
S. Buyuktimkin, N. Buyuktimkin, N. Ersoy, M. Tanol
, J. L. Walters, A. R.
Cohen, and J. H. Rytting, “ Influence of Storage Conditions of The Shed Snake
Skin of Three Species On Their Lipid Composition, Transdermal Delivery and
Retention of Diphenhydramine, Hydrocortisone, and Ketoprofen” presented at the
13th Annual AAPS Meeting, Abstract 3603.Pharm. Sci.
V:1, No:1, (1998).
B. Gozler, E. Erciyas, V. Pabuccuoglu, S. Gunes, M. Tanol
Chemistry III-IV Lecture Notes", Izmir, (1992).
, M.P. McIntosh, T. Siahaan, R.A. Rajewski. “Solvent Effects on The
Synthesis of N a-(Benzyloxycarbonyl)-Ne-(Chloromethyloxycarbonyl)-L-Lysine
amide” presented at the 224th ACS National Meeting, Boston, MA, August 18-22,
M.P. McIntosh, M. Tanol
, N. Schwarting, D.M. Pinson, S.C. Fowler and R.A.
Rajewski. “Targeted Methotrexate Delivery to activated T-cells via LFA-1
Receptors in Relapsing and Remitting Experimental Autoimmune
Encephalomyelitis Reduces relapse severity” presented at the American
Association of Pharmaceutical Scientists, National Biotechnology Conference,
San Francisco, 2005.
A. N. Lucas, M. Tanol
, M. P. McIntosh and R. A. Rajewski, Preparation and
purification of desethylamiodarone hydrochloride, Synthetic Communications
Vol. 36, Number 22, pp. 3371-3376 (2006).
Shelton Shary N; Shawgo Mary E; Matthews Shawna B; Lu Yuanming; Donnelly
Alison C; Szabla Kristen; Tanol Mehmet
; Vielhauer George A; Rajewski Roger
A; Matts Robert L; Blagg Brian S J; Robertson John D
Patent application title: PRODRUGS OF (3,5-BIS(4-FLUOROPHENYL)TETRAHYDRO-1H-OXAZOLO[3,4-C]OXAZOL-7A-YL)METHANOL AND DERIVATIVES THEREOF
IPC8 Class: AA61K314188FI
USPC Class: 514393
Patent application number: 20100056592Read more:
Patent application title : 2-METHOXYESTRADIOL (2-ME2) PRODRUG WITH ENHANCED BIOAVAILABILITY FOR PROPHLAXIS OR TREATMENT OF CANCEROUS OR NON-CANCEROUS CONDITION
Inventors: Suman Kambhampati, Roger A. Rajewski, Sushanta K. Banerjee, Mehmet Tanol
Agents: Dinesh Agarwal, P.C. 5350 Shawnee Road, Suite 330
Alexandria, VA,22312 U.S.A Docket Number: US 1547/10(Prov.)
Patent application title : PRODRUGS OF 6-CYCLOHEXYL-1-HYDROXY-4-METHYLPYRIDIN-2-(1H)-ONE AND DERIVATIVES THEREOF
Inventors: Mehmet Tanol
, Scott J. Weir. Agents : Workman Nydegger, 1000
Eagle Gate Tower ,Salt Lake City, UT US. Application Number: 61419218,
Attorney Docket Number: 16994.86
Patent application title: DECOQUINATE PRODRUGS AND METHODS OF SYNTHESIS AND TREATMENT
Inventors: Stefano Pogany, Mehmet Tanol
, Michael Baltezor Agents: Maschoff
Gilmore & Israelsen 1441 W. Utc Blvd., Suite 100 Park City, Utah 84098-763
US. Docket No: 10007US01
K. Kucukoglu , M. Tanol
“Synthesis of Some Pramoxine-Based Compounds as
Possible Local Anesthetic and Anticholinergic Agents”, Asian Journal of
, Vol. 22, No.5 (2010), 3404-3412.
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