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Gender differences in drinking patterns and alcohol-related problems in a community sample in Sa˜oPaulo, BrazilCamila Magalha˜es Silveira, Erica Rosanna Siu, Yuan-Pang Wang, Maria Carmen Viana, Arthur Guerra de Andrade, LauraHelena Andrade . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 Postmortem diagnosis of acute myocardial infarction in patients with acute respiratory failure -demographics, etiologic and pulmonary histologic analysisAlexandre de Matos Soeiro, Aline D. Ruppert, Mauro Canzian, Vera L. Capelozzi, Carlos V. Serrano, Jr. . . . . . . . . 213 Metabolic syndrome in patients with chronic hepatitis C virus genotype 1 infection who do not haveobesity or type 2 diabetesLucivalda Pereira Magalha˜es Oliveira, Rosangela P. de Jesus, Ramona SSB Boulhosa, Carlos Mauricio C. Mendes, AndreCastro Lyra, Luiz Guilherme C. Lyra . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 Applying the new concept of maternal near-miss in an intensive care unitFa´tima Aparecida Lotufo, Mary Angela Parpinelli, Samira Maerrawi Haddad, Fernanda Garanhani Surita, JoseGuilherme Cecatti . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225 Wilson’s disease: an analysis of 28 Brazilian childrenRodolpho Truffa Kleine, Renata Mendes, Renata Pugliese, Irene Miura, Vera Danesi, Gilda Porta . . . . . . . . . . . . . 231 Isolated limb perfusion with hyperthermia and chemotherapy: predictive factors for regional toxicityJoa˜o Pedreira Duprat Neto, Fernanda Oliveira, Eduardo Bertolli, Andre Sapata Molina, Kenji Nishinari, Luciana Facure,Jose Humberto Fregnani. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 Evaluation of serial C-reactive protein measurements after surgical treatment of pleural empyemaIsrael Lopes Medeiros, Ricardo Mingarini Terra, Esther Mihwa Choi, Paulo Manuel Pego-Fernandes, FabioBiscegli Jatene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 Prevalence of eye disease in Brazilian patients with psoriatic arthritisFernanda B. F. de Lima, Maria Fernanda Abalem, Danilo G. Ruiz, Beatriz de A. F. Gomes, Ma´rio N. L. de Azevedo,Haroldo V. Moraes, Jr, Ariyah Seth Yeskel, Newton Kara-Junior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249 Isolated total RNA and protein are preserved after thawing for more than twenty-four hoursIvone Braga de Oliveira, De´bora Rothstein Ramos, Karen Lucasechi Lopes, Regiane Machado de Souza, JoelClaudio Heimann, Luzia Naoˆko Shinohara Furukawa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255 Reporting on health-related research in two prestigious Brazilian newspapersRicardo Afonso Teixeira, Marcela Carlini, Arthur de Carvalho Jatoba´ e Sousa, Paula Teixeira Fernandes, Vera ReginaToledo Camargo, Carlos Vogt, Li Min Li . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261 Growth hormone response to growth-hormone-releasing peptide-2 in growth-hormone-deficientLittle miceCibele N. Peroni, Cesar Y. Hayashida, Nancy Nascimento, Viviane C. Longuini, Rodrigo A. Toledo, Paolo Bartolini,Cyril Y. Bowers, Sergio P.A. Toledo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265 Endothelial function in pre-pubertal children at risk of developing cardiomyopathy: a new frontierAline Cristina Tavares, Edimar Alcides Bocchi, Guilherme Veiga Guimara˜es. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 Surgery with intraoperative botulinum toxin-A injection for the treatment of large-angle horizontalstrabismus: a pilot studyNilza Minguini, Keila M. M. de Carvalho, Fa´bio L. S. Bosso, Fa´bio Endo Hirata, Newton Kara-Jose´ . . . . . . . . . . . 279 Assessing the benefits of rosiglitazone in women with polycystic ovary syndrome through its effects oninsulin-like growth factor 1, insulin-like growth factor-binding protein-3 and insulin resistance: a pilotstudyJose´ Gomes Batista, Jose´ Maria Soares-Jr, Carla Cristina Maganhin, Ricardo Santos Simo˜es, Geraldez Tomaz, EdmundChada Baracat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283 Evaluation of bacterial infections in organ transplantationSı´lvia Figueiredo Costa, Maristela Pinheiro Freire, Leonardo Borges B, & Silva, Edson Abdala, Lı´gia Pierrotti, Luis Se´rgioFonseca de Azevedo, Pedro Enrique Dorhiac-Ilacer, Tania Mara Vareja˜o Strabelli, Maria Aparecida Shikanai-Yasuda,Comissa˜o de Infecc¸a˜o em Imunodeprimidos, Hospital das Clı´nicas da Faculdade de Medicina da Universidade de Sa˜oPaulo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 Sclerosing mesenteritis as an unusual cause of fever of unknown origin: a case report and reviewVivian Iida Avelino-Silva, Fabio Eudes Leal, Caio Coelho-Netto, Guilherme Cutait de Castro Cotti, Ricardo A. S. Souza,Rodrigo Lautert Azambuja, Manoel de Souza Rocha, Esper Georges Kallas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293 Poststernotomy aspergillosis: successful treatment with voriconazole, surgical debridement andvacuum-assisted closure therapyRinaldo Focaccia Siciliano, Daniel Reis Waisberg, Marcos Naoyuki Samano, Paulo Ferreira Leite, Paulo Tuma Ju´nior,Guilherme Cardinali Barreiro, Tania Mara Vareja˜o Strabelli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297

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020702 reduction in the incidence of type 2 diabetes

C o py r ig ht © 2 0 0 2 by t he Ma s s ac h u s e t t s Me d ic a l S o c ie t y V O L U M E 3 4 6 REDUCTION IN THE INCIDENCE OF TYPE 2 DIABETES WITH LIFESTYLE INTERVENTION OR METFORMIN DIABETES PREVENTION PROGRAM RESEARCH GROUP* ABSTRACT Background non-insulin-dependent diabetes mellitus, isly 8 percent of adults in the United States. Some riska seriou

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