Microsoft word - shi _list of publications_100504.doc

LIST OF PUBLICATIONS
CLINICAL TRIALS OF HERBAL MEDICINAL PRODUCTS DEVELOPED BY
SWEDISH HERBAL INSTITUTE
KAN JANG tablets, fixed combination (Andrographis paniculata, Eleutherococcus
senticosus)
Cáceres, D.D., Hancke, J.L., Burgos, R.A., Sandberg, F., Wikman, G.K., 1998, "Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study", Phytomedicine, 6, 4, pp. 217-223. (PDF available) Cáceres, D.D., Hancke, J.L., Burgos, R.A., Wikman, G.K., 1997, "Prevention of common colds with Andrographis paniculata dried extract. A pilot double blind trial", Phytomedicine, 4, 2, pp. 101-104. (PDF available) Gabrielian, E.S., Shukarian, A.K., Goukasova, G.I., Chandanian, G.L., Panossian, A.G., Wikman, G., Wagner, H., 2002, “A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis”, Phytomedicine, 9, pp. 589-597. (PDF available) Gablielian E., Hovhannisyan A, Abrahamyan H., Panossian A., Wikman G. Effect of Kan Jang tablets and Echinacea purpurea extract on pharmacokinetic and pharmacodynamic of Warfarin in rats, Abstracts of World Congress of Pharmacy and Pharmaceutical Sciences , Singapore 1-6 September, 2001. PDM-P-072. Hancke, J., Burgos, R., Cáceres, D., Wikman, G., 1995, "A double-blind study with a new monodrug Kan Jang: Decrease of symptoms and improvement in the recovery from common colds", Phytotherapy Research, 9, 559-562. Kulichenko, L.L., Kireyeva, L.V., Malyshkina, E.N., Wikman, G., 2003, “A randomized controlled study of Kan Jang versus Amantadine in the treatment of influenza in Volgograd”, Journal of Herbal Pharmacotherapy, 3, 1, pp. 77-93. (PDF available) Melchior, J., Palm, S., Wikman, G., 1996/97, "Controlled clinicals study of standardized Andrographis paniculata extract in common cold - a pilot trial", Phytomedicine, 3, 4, pp. 315-318. (PDF available) Melchior, J., Spasov, A.A., Ostrovskij, O.V., Bulanov, A.E., Wikman, G., 1999, “Double blind placebo controlled pilot and Phase III study of a standardised Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper respiratory tract infection”, Phytomedicine, 7, 5, pp. 341-350. (PDF available) Spasov, A.A., Ostrovskij, O.V., Chernikov, M.V., Wikman, G., 2004, “Comparative Controlled Study of Andrographis paniculata Fixed Combination, Kan Jang® and an Echinacea Preparation as Adjuvant, in the Treatment of Uncomplicated Respiratory Disease in Children, Phytotherapy Research,18, pp 47-53. Panossian A., Oganessian A., Mamikonian G. Ambartsumian E., Gabrielian E., Wagner H., Wikman G. Pharmacokinetic and oral bioavailability of andrographolid (AND) from Andrographis paniculata extract (APE) in rats and humans Phytomedicine , 7(5), 351-364, 2000. (PDF available) G:\Information\Our studies\referenslistor på våra studier\SHI _list of publications_100504.doc Panossian A, A. Hovhannisyan, G. Mamikonyan, H. Abrahamian, E. Hambardzumyan, E. Gabrielian “Pharmacokinetic and Oral Bioavailability of Andrographolide from Andrographis paniculata Extract SHA-10 and Andrographis Fixed Combination Kan Jang in Rats and Humans” Drug Information Association, 12th Annual EuroMeeting 2000, Nice,France, pp 30. Panossian A, A. Hovhannisyan, G. Mamikonyan, H. Abrahamian, G. Goukasova, E. Gabrielian, G.Wikman, H.Wagner “Pharmacokinetic of Andrographolide from Andrographis paniculata Extract SHA-10 and Andrographis Fixed Combination Kan Jang in Rats and Humans” 3th International Congress on Phytomedicine, Supplement II, 2000, Munich, Germany, pp 118. KAN JANG mixture (Adathoda vasica, Echinacea purpurea, Eleutherococcus
senticosus)
Thom, E., Wollan, T., 1997, "A controlled clinical study of Kan Jang mixture in the treatment of uncomplicated upper respiratory tract infections", Phytotherapy Research, 11, pp. 207-210. Narimanian, M., Badalyan, M., Panosyan, V., Gabrielan, E., Panossian, A., Wikman, G., Wagner, H., 2005, “Randomized trial of a fixed combination (KanJang®) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections”, Phytomedicine, 12, 8, pp 539-547. Wikman, G., Panossian, A. “The efficacy of multi-drug therapy for the common cold with particular reference to Kan Jang fixed combination”. Abstract P 596, 55th International Congress and Annual Meeting of the Society form Medicinal Plant Research, September 2-6, 2007, Graz, Austria. Planta Medica, 73, pp. 100-101. ADAPTOGENS (Eleutherococcus senticosus, Rhodiola rosea, Schizandra
chinensis)
Aslanyan, G., Amroyan, E., Gabrielyan, E., Nylander, M., Wikman, G., Panossian, A., 2010. ”Double-blind, placebo-controlled, randomised study of single dose effects of Adapt-232 on cognitive functions”. Phytomedicine, 17, pp. 494-499. Bajevsky, R.M., Nikulina, G.A., Bogatova, R.I., Wikman, G., Roslyakova, N.A., 1998, "The study of the phytoadaptogen effect on the organism functional state based on the analysis of heart rate variability", draft report Bogatova, R.I., Shlykova, L.V., Salnitsky, V.P., Wikman, G., 1997, "Evaluation of the effect of a single dose of a phytoadaptogen on the working capacity of human subjects during prolonged isolation", Aerospace and Environmental Medicine, 31, 4, pp. 51-54. (ADAPT 232 chisan) Darbinyan, V., Aslanyan, G., Amroyan, E., Gabrielyan, E., Malmstrom, C., Panossian, A. 2007. “Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression”. Nordic Journal of Psychiatry, 61, 5, pp. 343-348. (PDF available) Darbinyan, V., Aslanyan, G., Amroyan, E., Gabrielyan, E., Malmstrom, C., Panossian, A. 2007. “Rhodidola SHR-5 extract and the treatment of depression”. Abstract SL 032, 55th International Congress and Annual Meeting of the Society form Medicinal Plant Research, September 2-6, 2007, Graz, Austria. Planta Medica, 73, pp. 813-814. (PDF available) Darbinyan, V., Kteyan, A., Panossian, A., Gabrielian, E., Wikman, G., Wagner, H., 1999, “Rhodiola rosea in stress induced fatigue – A double blind cross-over study of a standardized extract SHA-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty”, Phytomedicine, 7, 5, pp. 365-371. (SHR-5 rosenrot) (PDF available) Narimanian, M., Badalyan, M., Panosyan, V., Gabrielyan, E., Panossian, A., Wikman, G., Wagner, H., 2005, “ Impact of ChisanR (ADAPT 232) on the Quality – of - life and its Efficacy as an G:\Information\Our studies\referenslistor på våra studier\SHI _list of publications_100504.doc Adjuvant in the treatment of Acute Non-specific Pneumonia”, Phytomedicine, 12, pp 723-729. (ADAPT 232 chisan) (PDF available) Olsson EMG, von Schéele B, Panossian AG. A randomized double-blind placebo controlled parallell group study of SHR-5 extract of Rhodiola rosea roots as treatment for patients with stress related fatigue. Planta medica. 2009 Feb;75(2):105-12. Epub 2008 Nov 18. (PDF available) Panossian, A.G., Oganessian, A.S., Ambartsumian, M., Gabrelian, E.S., Wagner, H., Wikman, G., 1999, "Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva", Phytomedicine, 6, 1, pp. 17-26. (PDF available) Panossian A., V. Darbinyan , A. Kteyan, G. E. Gabrielian , G. Wikman Rhodiola rosea L. in stress induced fatigue – a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Drug Information Association, 36th Annual Meeting, June 11-15, 2000 Convention Center, San Diego, CA, USA Shevtsov, V.A., Zholus, B.I., Shervarly, V.I., Vol’skij, V.B, Korovin, Y.P., Khristich, M.P., Roslyakova, N.A., Wikman, G., 2003, “A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work”, Phytomedicine, 10, pp. 95-105. (SHR-5 rosenrot) (PDF available) Spasov, A.A., Wikman, G.K., Mandrikov, V.B., Mironova, I.A., Neumoin, V.V., 2000, “A double blind placebo controlled pilot study of the stimulating effect of Rhodiola rosea SHR-5 extract on the physical and mental work capacity of students during a stressful examination period with a repeated low-dose regimen”, Phytomedicine, 7, 2, pp. 85-89. (SHR-5 rosenrot) (PDF available) Schutgens FW, Neogi P, van Wijk EP, van Wijk R, Wikman G, Wiegant FA. The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment. Phytother Res. 2009 Jan 23. [Epub ahead of print] Other products
Toromanyan E, Aslanyan G, Amroyan E, Gabrielyan E., Panossian A. Efficacy of HerbaDiet® in overweight and obese human subjects. Phytotherapy Research. 2007 21(12):1177-81 Babayan S, Aslanyan G, Amroyan E, Gabrielyan E, Panossian A. Pilot clinical trial of KJJ in children with uncomplicated respiratory tract infections. Published in: Comprehensive Bioactive Natural Products, Vol 3. Efficacy, Safety & Clinical Evaluation II, ed. V.K Gupta. Studium Press LLC, U.S.A. 2010, pp. 297-307. Babayan S, Aslanyan G, Amroyan E, Gabrielyan E, Wikman G, Panossian A. Comparative study of Femineral® and Floradix® in women of child-bearing age and adolescent girls with iron deficiency anaemia. Scientia Pharmaceutica. 2008; 76: 725–742. doi:10.3797/scipharm.0807-17. PHARMACOLOGICAL STUDIES OF HERBAL MEDICINAL PRODUCTS
DEVELOPED BY SWEDISH HERBAL INSTUTUTE
KAN JANG tablets (Andrographis paniculata, Eleutherococcus senticosus)
Amroyan, E., Gabrelian, E., Panossian, A., Wikman, G., Wagner, H., 1999, "Inhibitory effect on andrographolide from Andrographis paniculata on PAF-induced platelet aggregation", Phytomedicine, 6, 1, pp. 27-31. (PDF available) Hovhannisyan, A.S., Abrahamyan, H., Gabrielyan,E.S., Panossian, A.G., 2006, ”The effect of Kan Jang Extract on the pharmacoinetics and pharmacodynamics of warfarin in rats”, Phytomedicine, 13, 5, pp 318-323. (PDF available) G:\Information\Our studies\referenslistor på våra studier\SHI _list of publications_100504.doc Panossian, A., Davtyan, T., Gukassyan, N., Gukasova, G., Mamikonyan, G., Gabrielian, E., Wikman, G., 2002, “Effect of Andrographolide and Kan Jang fixed combination of extract SHA-10 and extract SHE-3 on proliferation of cytokines and immune activation markers in the whole blood cells culture”, Phytomedicine, 9, pp. 598-605. Panossian, A., Hovhannisyan, A., Mamikonian, G., Abrahamian, H., Hambardzumyan, E., Gabrielian, E., Goukasova, G., Wikman, G., Wagner, H., 2000, “Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan jang in rats and human”, Phytomedicine, 7, 5, pp. 351-364.(PDF available) ADAPTOGENS (Eleutherococcus senticosus, Rhodiola rosea, Schizandra chinensis)
Abrahamyan H, Hovhannisyan A., Gabrielyan E. Panossian A., Pharmacokinetic study of salidroside and rosavin, active principles of Rhodiola rosea in rats by high performance capillary electrophoresis system. Drugs and medicine, No. 3, pp. 55-61, 2004. Abrahamyan H, Hovhannisyan A., Panossian A., Gabrielyan E. The bioavailability of salidroside and rosavin, active principles of Rhodiola rosea extract SHR-5 in rats. Medical Science of Armenia, 45 (1), 24-29, 2005. Ahumada, F., Hermosilla, R., Hola, R., Pena, R., Wittwer, F., Wegmann, E., Hancke, J., Wikman, G., 1989, “Studies on the Effect of Schizandra chinensis Extract on Horses Submitted to Exercise and maximum Effort “, Phytotherapy Research, 3 (5), pp 175-179. Bogatova, R.I., Guryeva, T.S., Lebedeva, Z.N., Wikman, G., Palm, S., Roslyakova, N.A., 1996, "Avian reproductive function under a combined effect of phytoadaptogens and some factors of a space flight", ACTA Vet. Brno., 65, pp. 87-92. Boon-Niermeijer, E.K., van der Berg, A., Wikman, G., Wiegant, F.A.C., 2000, “Phyto-adaptogens stimulate recovery from intoxication with copper or cadmium in larvae of Lymnaea stagnalis”, Phytomedicine, 7, 5, pp. 389-399. (Rosenrot) (PDF available) Hancke, J., Burgos, R., Cáceres, D., Brunetti, F., Durigon, A., Wikman, G., 1996, "Reduction of serum hepatic transaminases and CPK in sport horses with poor performance treated with a standardized Schizandra chinensis fruit extract", Phytomedicine, 3, 3, pp. 237-240. (PDF available) Hancke, J., Burgos, R., Wikman, G., Ewertz, E., Ahumada, F., 1994, "Schizandra chinensis, a potential phytodrug for recovery of sport horses", Fitoterapia, 125, 2, pp. 113-118. Hernandez, D.E., Hancke, J.L., Wikman, G., 1988, "Evaluation of the anti-ulcer and antisecretory activity of extracts of Aralia elata root and Schizandra chinensis fruit in the rat", Journal of Ethnopharmacology, 23, pp. 109-114. Makarov V., Makarova M.N., Stoloschyck N.V., Wikman G., Panossian A. Potential use of plant adaptogens in age-related disorders . Book of Abstracts. 2nd World Conference of Stress, 23-26 August 2007, 3rd Cell stress Society International Congress on Stress Responses in Biology and Medicine, Budapest, Hungary, p.242 Malyshev, L.Y., 1995, “Study of the effect of adaptogens of natural origin on synthesis of heat shock proteins”, Russian Academy of medical Sciences Institute of General Pathology and Pathophysiology, SCIENTIFIC REPORT in accordance with agreement between “Interstam AB and Institute of general pathology and Pathophysiology G:\Information\Our studies\referenslistor på våra studier\SHI _list of publications_100504.doc Malyshev, I.Yu., Prodius, P.A., Arckhipenko, Yu.V., Wikman, G., Meerson, F.Z., 1997, "A new approach to studying the mechanism of action ans searching form criteria od adaptogen activity", presented at the 5th World Congress International Society For Adaptive Medicine (ISAM). Panossian, A., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., Wikman, G. 2010. ”Pharmacokinetics of active constituents of Rhodiola rosea SHR-5 extract”. In the book: Comprehensive Bioactive Natural Products – Efficacy, Safety & Clinical Evaluation I, Vol 2. Ed. Gupta V.K., pp. 308-329. Studium Press LLC, Texas, USA, printed at Thomspn Press (India) Ltd. Panossian, A.G., Oganessian, A.S., Ambartsumian, M., Gabrelian, E.S., Wagner, H., Wikman, G., 1999, "Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva", Phytomedicine, 6, 1, pp. 17-26. (PDF available) Panossian A., Hovhannisyan A, Abrahamyan H., Gablielian E., Wikman G. Pharmacokinetic of salidroside and rosavin, from a standardized Rhodiola rosea extract SHR-5 in rats. Pharmavologist 44 (2) Suppl 1, 100.7 (2002) Panossian, A. Hovhannisyan, H. Abrahamyan, G. Wikman, Pharmacokinetics of active constituents of Rhodiola rosea L. special extract SHR-5. “Bioactive Natural Products”, Studium Press LLC, USA, 2008. Panossian A., Wikman G., Kaur P., Asea A. Adaptogens exert a stress protective effect by modulation of expression of molecular chaperons. Phytomedicine, 2009 Jun;16(6-7):617-22. Epub 2009 Feb 1. (PDF available) Panossian A., Hambartsumyan M, Hovhanissyan A. and Wikman G. Adaptogens modify stress response suppressing the increase of p-SAPK, nitric oxide and cortisone in blood of rabbits. Abstract S 013, 54th International Congress and Annual Meeting of the Society form Medicinal Plant Research, 29 August – 2 September, 2006, Helsinki, Finland. Planta Medica, 72, p. 968. Panossian A., Hambartsumyan M., Hovanissian A, Gabrielyan E., Wikman G. G. The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol Drug Turgets Instights, 1, 39-54, 2007; http://la-press.com/cr_data/files/f_DTI-2-Panossian-et-al_290.pdf (PDF available) Panossian A., Wikman G., Hambartsumyan M., Hovhanissyan A. Adaptogens – modifiers of stress response Book of Abstracts. 2nd World Conference of Stress, 23-26 August 2007, 3rd Cell stress Society International Congress on Stress Responces in Biology and Medicine, Budapest, Hungary, p.69. Panossian, A., Nikoyan, N., Ohanyan, N., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E, Wikman, G., 2008, “Comparative study of Rhodiola preparations on behavioural despair of rats”, Phytomedicine, 15, pp. 84-891. (PDF available) Panossian A, Hovhannisyan A, Abrahamyan H, Gabrielyan E, Wikman G. Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats. Phytother Res. 2009 Mar; 23(3):351-7. Panossian, A., Wikman, G., 2006, “The pharmacology of plant adaptogens: an overview with particular reference to their mechanisms of action and indications” , International Society for Adaptive Medicine, (ISAM), VIII World Congress June 21-24, Moscow, Russia. Shirinyan, E., Panossian, A., Wikman, G., 2006, “Single dose effects of adaptogens: the synergistic and antagonistic effects of their fixed combinations on endurance and hypoxia of rats subjected to a forced swimming test”, International Society for Adaptive Medicine, (ISAM), VIII World Congress June 21-24, Moscow, Russia. G:\Information\Our studies\referenslistor på våra studier\SHI _list of publications_100504.doc Wiegant, F.A.C., Surinova, S., Ytsma, E., Langelaar-maakinje, M., Post, J-A., Wikman, G., 2006, “Life-span enhancing effects of plant adaptogens in C. elegans”. International Society for Adaptive Medicine, (ISAM), VIII World Congress June 21-24, Moscow, Russia. Wiegant, F.A.C., Limandjaja, G., Bayda, L., Zenina, T.A., Vorontsova, O., Malyshev, I.Yu., Wikman, G., Langelaar-Makkinje, M., Post, J.A., 2006, ”Mild Oxidative stress by plant adaptogens initiates self-defense mechanisms in cells”, International Society for Adaptive Medicine, (ISAM), VIII World Congress June 21-24, Moscow, Russia. Wiegant, F.A.C., Limandjaja, G., de Poot, S.A.H., Bayda, L.A., Vorontsova, O.N., Zenina, T.A., Langelaar-Makinje, M., Post, J.A., Wikman, G., . 2006, “Plant adaptogens activate cellular adaptive mechanisms by causing mild damage”, ISAM (international Society for Adaptiove medicine) Congress held in Moscow in June. (PDF available) Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology. 2009 Feb;10(1):27-42. Epub 2008 Jun 7. OTHER PREPARATIONS
Amaryan G., Astvatsatryan. V., Gabrielyan, E., Panossian, A., Panosyan, V., Wikman, G. 2002, “Double-blind, placebo-controlled, randomized, pilot clinical trial of Immuno-Guard® - a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever”, Clinical and Experimental Rheumatology, 20, 4, p. 104. Amaryan G., Astvatsatryan. V., Gabrielyan, E., Panossian, A., Panosyan, V., Wikman, G. 2003, “Double-blind, placebo-controlled, randomized, pilot clinical trial of Immuno-Guard® - a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Phytomedicine, 10, 4, pp. 271-285. Babayan S, Aslanyan G, Amroyan E, Gabrielyan E, Panossian A. Pilot clinical trial of Kan Jang Junior in children with uncomplicated respiratory tract infections. In: Compendium of Bioactive Natural Products Vol. 2: Efficacy, Safety & Clinical Evaluation (Part-1) Studium Press LLC, USA,2009. pp. in press. Panossian A., Davtyan, T., Panosyan, V., Mamikonyan, G., Wikman, G. 2003. “g-Interferon-inducing and antiviral activity of extracts of Nerium oleander and Glycyrrhiza glabra, and of a fixed combination of these extracts (NatuGuard®) In: 3rd International Symposium on Natural Drugs”, Proceedings, Eds. F.Borelli, F.Capasso, N.Milic, A.Russo. Naples, 2-4 October, Grafidea S.r.l.Milano. pp. 211-214. Panossian A., Hambartsumyan, M., Panosyan, L., Abrahamyan, H., Gabrielyan, E., Amaryan, G., Astvatsatryan, V., Wikman, G. 2002, “Plasma nitric oxide level in Familial Mediterranean Fever”, Clinical and Experimental Rheumatology, 20, 4, p. 78. Ter-Grigoryan V., Panosyan, V., Panossian, A., Wikman, G. 2003, “Comparative evaluation of the efficacy and safety of multiple doses of Cardiohealth in comparison with Renitec in patients with mild to moderate hypertension”, In: 3rd International Symposium on Natural Drugs. Proceedings, Eds. F.Borelli, F.Capasso, N.Milic, A.Russo. Naples, 2-4 October, Grafidea S.r.l.Milano. pp. 223-226. Drug analysis
Panossian A, A. Danielyan, G.Mamikonyan and G.Wikman. Methods of Phytochemical Standardisation of Rhizoma Cimicifugae racemosae Phytochem.Anal .15 ,100-108, 2004 G:\Information\Our studies\referenslistor på våra studier\SHI _list of publications_100504.doc Panossian A, A. Danielyan, G.Mamikonyan, G.Wikman, Methods of phytochemical standardization of Rhizoma Cimicifugae Racemosae3rd International Symposium on Natural Drugs, October 2-4, 2003, Naples, Italy, p. 149. Panossian A, A. Dainelyan, M. Mkrtichyan, G.Mamikonyan, G.Wikman, S.Isupov Phytochemical study of Mumiyo 3rd International Symposium on Natural Drugs, October 2-4, 2003, Naples, Italy, p. 148. Panossian A., A. Danielyan, G.Mamikonyan, G.Wikman, Methods of phytochemical standardization of Rhizoma Cimicifugae Racemosae, In: 3rd International Symposium on Natural Drugs. Proceedings, Eds. F.Borelli, F.Capasso, N.Milic, A.Russo. Naples, 2-4 October 2003, Grafidea S.r.l.Milano. pp. 219-222. Panossian A, A. Dainelyan, M. Mkrtichyan, G.Mamikonyan, G.Wikman, S.Isupov Phytochemical study of Mumiyo 3rd International Symposium on Natural Drugs, October 2-4, 2003, Naples, Italy, p,148. Mamikonyan G., A.Panossian, E.Gabrielian, G.Wikman. Developing of the methods of analysis of Andrographolide Medical Science of Armenia. 2002. Vol. XLII, No. 2, pp. 11-19. Review Articles
Panossian A., Wikman, G., Wagner, H., Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of actions. Phytomedicine, 6 (4), 287-300, 1999 Panossian A.G. Adaptogens: Tonic herbs for fatigue and stress. Alternative & Complimentary therapies. Vol 9, No 6, pp. 327-332. 2003. Panossian A.G. Adaptogens. A historical Overview and Perspective. Natural pharmacy. Vol. 7 No.4, July August 2003, pp.1,19-20. Panosyan A., .Wagner H. Stimulating effects of adaptogens: an overview of clinical trials of adaptogens with particular reference on their efficacy at single dose administration – Phytotherapy research, 2005 19 (10):819-838. Panossian A, Wikman G. Effect of adaptogens on the central nervous system Arquivos Brasileiros de Fitomedicina Científica • Vol. 2. Nr 2- Maio de 2005, pp.108-130. Panossian A., Wikman G. Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine. Journal of Ethnopharmacology. Vol 118/2 pp 183-212 DOI information: 10.1016/j.jep.2008.04.020 DOI: http://dx.doi.org/10.1016/j.jep.2008.04.020 Panossian A, Wikman G. Evidence-Based Efficacy of Adaptogens in Fatigue, and Molecular Mechanisms Related to Their Stress-Protective Activity. Curr Clin Pharmacol. 2009 Sep 1. [Epub ahead of print] Panossian, A., Wikman, G., Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals 2010, 3, pp. 118-224. Panossian, A., Wikman, G., Sarris, J., 2010. “Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy”. Phytomedicine, 17, pp. 481-493. G:\Information\Our studies\referenslistor på våra studier\SHI _list of publications_100504.doc

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