Sgu.edu

Antibiotic susceptibility pattern of fecal indicator bacteria isolated from owned dogs in Grenada: a
pilot study

V A Amadi1, A H Werners2, and H Hariharan1 1Pathobiology Academic Program, School of Veterinary Medicine, St George’s University, Grenada, West Indies. 2 Anatomy and Physiology Academic Program, School of Veterinary Medicine, St George’s University, Grenada, West Indies. Objective: To determine 1) the occurrence of doxycycline-resistant fecal indicator bacteria: Escherichia
coli, Klebsiella pneumoniae, and Enterococcus faecalis from dogs and 2) the antimicrobial susceptibility
of the doxycycline-resistant isolates to other antibiotics
Methodology: Anal swabs collected from 14 dogs were tested for the presence of doxycycline-resistant
bacterial indicators by a selective culture method. Eosin-methylene-blue medium supplemented with
25µg/ml doxycycline was used to isolate doxycycline-resistant E. coli and K. pneumoniae while
doxycycline-resistant E. faecalis was isolated using Kenner-fecal medium supplemented with 10µg/ml
doxycycline. Pure cultures of the isolates were identified using phenotypic characteristics. The
antimicrobial susceptibility of the doxycycline-resistant isolates was determined against 12 antibiotics
using the Kirby-Bauer method.
Result: Of the 14 dogs tested, the percentage that was positive for doxycycline-resistant bacterial
indicators were: 11(79%) for doxycycline-resistant E. coli, 7(50%) for doxycycline-resistant K.
pneumoniae
, and 8(57%) doxycycline-resistant E. faecalis. Based on our Kirby-Bauer assay results,
5(45%) of the doxycycline-resistant E. coli isolates were resistant to a single antibiotic, and 2(18%)
isolates presented multiple antibiotic resistance. The doxycycline-resistant E. coli isolated showed
resistance to two other antibiotics, tetracycline (45%) and cephalothin (27%). In comparison to the
doxycycline-resistant E. coli isolated, 1(14%) doxycycline-resistant K. pneumoniae isolate was resistant
to single antibiotic, and 5(71%) isolates showed multiple antibiotic resistance. The doxycycline-resistant
K. pneumoniae isolated showed resistance to seven other antibiotics: amoxicillin/clavulanate (57%),
ampicillin (86%), neomycin (14%), gentamicin (14%), tetracycline (29%), cefovecin (57%) and
cephalothin (57%). Two (25%) doxycycline-resistant E. faecalis were resistant to single antibiotic, and
6(75%) isolates showed multiple antibiotic resistance. The doxycycline-resistant E. faecalis isolated
showed resistance to eight other antibiotics: ampicillin (13%), neomycin (75%), gentamicin (38%),
trimethoprim/sulfamethoxazole (13%), tetracycline (100%), cefovecin (50%), cephalothin (63%), and
Imipenem (13%).
Conclusion: The tested dogs harbor doxycycline-resistant bacterial indicators in their intestine. The
doxycycline-resistant isolates were also resistant to other antibiotics.

Source: http://www.sgu.edu/research/pdf/phizeta-2013-abstracts/Link11.pdf

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