Physiologie2.uni-erlangen.de

Publications Prof. Dr. med. C. Korbmacher
Original articles
Rauh R, Soell D, Haerteis S, Diakov A, Nesterov V, Krueger B, Sticht H, Korbmacher C. A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect. Am J Physiol Lung Cell Mol Physiol. 2013;304:L43-55 L'Hoste S, Diakov A, Andrini O, Genete M, Pinelli L, Grand T, Keck M, Paulais M, Beck L, Korbmacher C, Teulon J, Lourdel S. Characterization of the mouse ClC-K1/Barttin chloride channel. Biochim Biophys Acta. 2013;1828:2399-2409 Lefèvre CM, Diakov A, Haerteis S, Korbmacher C, Gründer S, Wiemuth D. Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC). Pflügers Arch. 2013 (Epub ahead of print) Jensen D, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU. The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. J Biol Chem. 2013 (Epub ahead of print) Nesterov V, Dahlmann A, Krueger B, Bertog M, Loffing J, Korbmacher C. Aldosterone- dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron. Am J Physiol Renal Physiol. 2012;303:F1289-1299 Krueger B, Schlötzer-Schrehardt U, Haerteis S, Zenkel M, Chankiewitz VE, Amann KU, Kruse FE, Korbmacher C. Four subunits (αβγδ) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations. Invest. Ophthalmol. Vis. Sci. 2012;53:596- Haerteis S, Schaal D, Brauer F, Bruschke S, Schweimer K, Rauh R, Sticht H, Rösch P, Schwarzinger S, Korbmacher C. An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation. Cell Physiol Biochem. Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C. Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ-subunit of the human epithelial sodium channel. J. Gen. Physiol. 2012;140:375-389 Haerteis S, Krappitz M, Bertog M, Krappitz A, Baraznenok V, Henderson I, Lindstrom E, Murphy JE, Bunnett NW, Korbmacher C. Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflügers Arch. 2012;464:353-365 Stewart AP, Haerteis S, Diakov A, Korbmacher C, Edwardson JM. Atomic force microscopy reveals the architecture of the epithelial sodium channel (ENaC). J Biol Chem. Rauh R, Diakov A, Tzschoppe A, Korbmacher J, Azad AK, Cuppens H, Cassiman JJ, Dötsch J, Sticht H, Korbmacher C. A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition. J. Physiol. Huber R, Krueger B, Diakov A, Korbmacher J, Haerteis S, Einsiedel J, Gmeiner P, Azad AK, Cuppens H, Cassiman JJ, Korbmacher C, Rauh R. Functional characterization of a partial loss- of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis. Cell Physiol Biochem. 2010;25:145-158 Diakov A, Nesterov V, Mokrushina M, Rauh R, Korbmacher C. Protein kinase B α (PKBα) stimulates the epithelial sodium channel (ENaC) heterologously expressed in Xenopus laevis oocytes by two distinct mechanisms. Cell Physiol Biochem. 2010;26:913-924 2005 - 2009:
Svenningsen P, Bistrup C, Fri s UG, Bertog M, Haerteis S, Krueger B, Stubbe J, Jensen ON, Thiesson HC, Uhrenholt TR, Jespersen B, Jensen BL, Korbmacher C, Skøtt O. Plasmin in nephrotic urine activates the epithelial sodium channel. J. Am. Soc. Nephrol. 2009;20:299- Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Wil am C. HIF-prolyl hydroxylases in the rat kidney: Physiologic expression patterns and regulation in acute kidney injury. Am. J. Pathol. 2009;174:1663-1674 Krueger B, Haerteis S, Yang L, Hartner A, Rauh R, Korbmacher C, Diakov A. Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1. Cell Physiol Biochem. 2009;24:605-618 Haerteis S, Krueger B, Korbmacher C, Rauh R. The δ-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation. J Biol Chem. Azad AK, Rauh R, Vermeulen F, Jaspers M, Korbmacher J, Boissier B, Bassinet L, Fichou Y, des Georges M, Stanke F, De Boeck K, Dupont L, Balascakova M, Hjelte L, Lebecque P, Radojkovic D, Castellani C, Schwartz M, Stuhrmann M, Schwarz M, Skalicka V, de Monestrol I, Girodon E, Ferec C, Claustres M, Tummler B, Cassiman JJ, Korbmacher C, Cuppens H. Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease. Nesterov V, Dahlmann A, Bertog M, Korbmacher C. Trypsin can activate the epithelial sodium channel (ENaC) in microdissected mouse distal nephron. Am J Physiol. 2008;295:F1052-1062 Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C. Cleavage in the g-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels. J. Physiol. 2008;586:4587-4608 Bertog M, Cuffe JE, Pradervand S, Hummler E, Hartner A, Porst M, Hilgers KF, Rossier BC, Korbmacher C. Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome. J. Physiol. 2008;586:459-475 Wielpütz MO, Lee IH, Dinudom A, Boulkroun S, Farman N, Cook DI, Korbmacher C, Rauh R. (NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and Fisher rat thyroid cells. J Biol Chem. 2007;282:28264-28273 Kraus C, Reis A, Naehrlich L, Dötsch J, Korbmacher C, Rauh R. Functional characterization of a novel CFTR mutation P67S identified in a patient with atypical cystic fibrosis. Cell Physiol Yang LM, Rinke R, Korbmacher C. Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's b- and g- subunit. J Biol Chem. 2006;281:9859-9868 Rauh R, Dinudom A, Fotia AB, Paulides M, Kumar S, Korbmacher C, Cook DI. Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (SGK) involves the PY motifs of the channel but is independent of sodium feedback inhibition. 2000 - 2004:
Zdebik AA, Cuffe JE, Bertog M, Korbmacher C, Jentsch TJ. Additional disruption of the ClC-2 Cl- channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models. J Biol Chem. 2004;279:22276-22283 Volk T, Konstas AA, Bassalay P, Ehmke H, Korbmacher C. Extracellular Na+ removal attenuates rundown of the epithelial Na+-channel (ENaC) by reducing the rate of channel retrieval. Sandrasagra S, Cuffe JE, Regardsoe EL, Korbmacher C. PGE2 stimulates Cl- secretion in murine M-1 cortical collecting duct cells in an autocrine manner. Pflügers Arch. 2004;448:411-421 Diakov A, Korbmacher C. A novel pathway of ENaC activation involves an SGK1 consensus motif in the C-terminus of the channel's a-subunit. J Biol Chem. 2004;279:38134-38142 Konstas AA, Korbmacher C, Tucker SJ. Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. Am J Physiol. 2003;284:C910-917 Konstas AA, Korbmacher C. The g-subunit of ENaC is more important for channel surface expression than the b-subunit. Am J Physiol. 2003;284:C447-456 Konstas AA, Koch JP, Korbmacher C. cAMP-dependent activation of CFTR inhibits the epithelial sodium channel (ENaC) without affecting its surface expression. Pflügers Arch. Fotia AB, Dinudom A, Shearwin KE, Koch JP, Korbmacher C, Cook DI, Kumar S. The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium Yun CC, Palmada M, Embark HM, Fedorenko O, Feng Y, Henke G, Setiawan I, Boehmer C, Weinman EJ, Sandrasagra S, Korbmacher C, Cohen P, Pearce D, Lang F. The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. J. Am. Soc. Nephrol. Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S. Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2- interacting protein. J Biol Chem. 2002;277:29406-29416 Konstas AA, Koch JP, Tucker SJ, Korbmacher C. CFTR-dependent upregulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel (ENaC). J Biol Chem. Konstas AA, Dabrowski M, Korbmacher C, Tucker SJ. Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B: Implications for the identity of the renal ATP- regulated secretory K+ channel. J Biol Chem. 2002;1:1 Cuffe JE, Howard DP, Bertog M, Korbmacher C. Basolateral adrenoceptor activation mediates noradrenaline-induced Cl- secretion in M-1 mouse cortical collecting duct cells. Pflügers Arch. Cuffe JE, Bertog M, Velazquez-Rocha S, Dery O, Bunnett N, Korbmacher C. Basolateral PAR-2 receptors mediate KCl secretion and inhibition of Na+ absorption in the mouse distal colon. J. Howard DP, Cuffe JE, Boyd CA, Korbmacher C. L-arginine effects on Na+ transport in M-1 mouse cortical collecting duct cells - a cationic amino acid absorbing epithelium. J Membr Konstas A-A, Bielfeld-Ackermann A, Korbmacher C. Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression. Pflügers Arch, 2001;442:752-761 Konstas A-A, Mavrelos D, Korbmacher C. Conservation of pH sensitivity in the epithelial sodium channel (ENaC) with Liddle's syndrome mutation. Pflügers Arch. 2000;441:341-350 Koch J-P, Korbmacher C. Mechanism of shrinkage activation of nonselective cation channels in M-1 mouse cortical collecting duct cells. J Membr Biol. 2000;177:231-242 Cuffe JE, Bielfeld-Ackermann A, Thomas J, Leipziger J, Korbmacher C. ATP stimulates Cl- secretion and reduces amiloride-sensitive Na+ absorption in M-1 mouse cortical collecting duct cel s. J. Physiol. 2000;524:77-90 Bertog M, Smith DJ, Bielfeld Ackermann A, Bassett J, Ferguson DJ, Korbmacher C, Harris A. Ovine male genital duct epithelial cells differentiate in vitro and express functional CFTR and ENaC. Am J Physiol. 2000;278:C885-894 1995 - 1999:
Koch J-P, Korbmacher C. Osmotic shrinkage activates nonselective cation (NSC) channels in various cell types. J Membr Biol. 1999;168:131-139 Bertog M, Letz B, Kong W, Steinhoff M, Higgins MA, Bielfeld Ackermann A, Frömter E, Bunnett NW, Korbmacher C. Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells. J. Physiol. 1999;521:3-17 Bielfeld Ackermann A, Range C, Korbmacher C. Maitotoxin (MTX) activates a nonselective cation channel in Xenopus laevis oocytes. Pflügers Arch. 1998;436:329-337 Letz B, Schomerus C, Maronde E, Korf HW, Korbmacher C. Stimulation of a nicotinic Ach receptor causes depolarization and activation of L-type Ca2+ channels in rat pinealocytes. J. Letz B, Korbmacher C. cAMP stimulates CFTR-like Cl- channels and inhibits amiloride-sensitive Na+ channels in mouse CCD cells. Am J Physiol. 1997;272:C657-666 Meyer K, Korbmacher C. Cell swelling activates ATP-dependent voltage-gated chloride channels in M-1 mouse cortical colllecting duct cells. J. Gen. Physiol. 1996;108:177-193 Volk T, Rabe A, Korbmacher C. Glibenclamide inhibits an outwardly rectifying chloride channel in M-1 mouse cortical collecting duct cells. Cell Physiol Biochem. 1995;5:222-231 Volk T, Frömter E, Korbmacher C. Hypertonicity activates nonselective cation channels in mouse cortical collecting duct cells. Proc. Natl. Acad. Sci. USA. 1995;92:8478-8482 Letz B, Ackermann A, Canessa CM, Rossier BC, Korbmacher C. Amiloride-sensitive sodium channels in confluent M-1 mouse cortical collecting duct cells. J Membr Biol. 1995;148:127- Korbmacher C, Volk T, Segal AS, Boulpaep EL, Frömter E. A calcium-activated and nucleotide- sensitive nonselective cation channel in M-1 mouse cortical collecting duct cells. J Membr 1990 - 1994:
Korbmacher C, Segal AS, Fejes-Tóth G, Giebisch G, Boulpaep EL. Whole-cell currents insingle and confluent M-1 mouse cortical collecting duct cells. J. Gen. Physiol. 1993;102:761-793 Korbmacher C, Boulpaep EL, Giebisch G, Geibel J. Endothelin increases [Ca2+]i in M-1 mouse cortical collecting duct cells by a dual mechanism. Am J Physiol. 1993;265:C349-C357 Ahmad I, Korbmacher C, Segal AS, Cheung P, Boulpaep EL, Barnstable CJ. Mouse cortical collecting duct cells show nonselective cation channel activity and express a gene related to the cGMP-gated rod photoreceptor channel. Proc. Natl. Acad. Sci. USA. 1992;89:10262- Erickson-Lamy K, Korbmacher C, Schuman JS, Nathanson JA. Effect of endothelin on outflow facility and accommodation in the monkey eye in vivo. Invest. Ophthalmol. Vis. Sci. Coroneo MT, Korbmacher C, Flügel C, Stiemer B, Lütjen-Drecoll E, Wiederholt M. Electrical and morphological evidence for heterogeneous populations of cultured bovine trabecular meshwork cells. Exp. Eye Res. 1991;52:375-388 Korbmacher C, Helbig H, Coroneo M, Erickson-Lamy KA, Stiemer B, Tamm E, Lütjen-Drecoll E, Wiederholt M. Membrane voltage recordings in a cell line derived from human ciliary muscle. Invest. Ophthalmol. Vis. Sci. 1990;31:2420-2430 Helbig H, Korbmacher C, Wiederholt M. Mechanism of ascorbic acid transport in the aqueous humor. Fortschr Ophthalmol. 1990;87:421-424 1985 - 1989:
Korbmacher C, Schulz W, König M, Siebe H, Lichtenstein I, Hierholzer K. Renal epithelial cell lines (BSC-1, MDCK, LLC-PK1) express 11 b-hydroxysteroid dehydrogenase activity. Biochim Korbmacher C, Helbig H, Stahl F, Coroneo M, Haller H, Lindschau C, Quass P, Wiederholt M. Continuous membrane voltage recordings in A10 vascular smooth muscle cells: Effect of AVP. Korbmacher C, Helbig H, Haller H, Erickson-Lamy KA, Wiederholt M. Endothelin depolarizes membrane voltage and increases intracellular calcium concentration in human ciliary muscle cells. Biochem. Biophys. Res. Commun. 1989;164:1031-1039 Korbmacher C, Helbig H, Förster C, Wiederholt M. Measuring intracellular pH in cultivated corneal epithelial cells. Fortschr Ophthalmol. 1989;86:279-282 Korbmacher C, Helbig H, Blank M, Dressler S, Stahl F, Wiederholt M. Characterization of Cl-/ HCO -3 exchange in A10 vascular smooth muscle cells using 36Cl-. Biochim Biophys Acta. Helbig H, Korbmacher C, Wohlfarth J, Coroneo MT, Lindschau C, Quass P, Haller H, Coca- Prados M, Wiederholt M. Effect of acetylcholine on membrane potential of cultured human nonpigmented ciliary epithelial cells. Invest. Ophthalmol. Vis. Sci. 1989;30:890-896 Helbig H, Korbmacher C, Wohlfarth J, Coca-Prados M, Wiederholt M. Intracellular voltage recordings in bovine non-pigmented ciliary epithelial cells in primary culture. Curr. Eye Res. Helbig H, Korbmacher C, Wohlfarth J, Coca-Prados M, Wiederholt M. Electrical membrane properties of a cell clone derived from human nonpigmented ciliary epithelium. Invest. Ophthalmol. Vis. Sci. 1989;30:882-889 Helbig H, Korbmacher C, Wohlfarth J, Berweck S, Kühner D, Wiederholt M. Electrogenic Na+- ascorbate cotransport in cultured bovine pigmented ciliary epithelial cells. Am J Physiol. Helbig H, Korbmacher C, Stumpff F, Coca-Prados M, Wiederholt M. Role of HCO - regulation of cytoplasmic pH in ciliary epithelial cells. Am J Physiol. 1989;257:C696-705 Helbig H, Korbmacher C, Nawrath M, Erb C, Wiederholt M. Sodium bicarbonate cotransport in cultured pigmented ciliary epithelial cells. Curr. Eye Res. 1989;8:595-598 Helbig H, Korbmacher C, Erb C, Nawrath M, Knuuttila KG, Wistrand P, Wiederholt M. Carbonic anhydrase and its function in ion transport in cultivated pigmented ciliary body epithelial cells. Fortschr Ophthalmol. 1989;86:474-477 Helbig H, Korbmacher C, Erb C, Nawrath M, Knuuttila KG, Wistrand P, Wiederholt M. Coupling of 22Na and 36Cl uptake in cultured pigmented ciliary epithelial cells - a proposed role for the isoenzymes of carbonic anhydrase. Curr. Eye Res. 1989;8:1111-1119 Coroneo MT, Helbig H, Korbmacher C, Wiederholt M. Effect of hypotonic media on the membrane voltage of cultured bovine corneal endothelial cells. Curr. Eye Res. 1989;8:891- Korbmacher C, Helbig H, Stahl F, Wiederholt M. Evidence for Na/H exchange and Cl/HCO3 exchange in A10 vascular smooth muscle cells. Pflügers Arch. 1988;412: 29-36 Korbmacher C, Helbig H, Förster C, Wiederholt M. Characterization of Na+/H+ exchange in a rabbit corneal epithelial cell line (SIRC). Biochim Biophys Acta. 1988;943:405-410 Korbmacher C, Helbig H, Förster C, Wiederholt M. Evidence for Na+/H+ exchange and pH sensitive membrane voltage in cultured bovine corneal epithelial cells. Curr. Eye Res. Jentsch TJ, Korbmacher C, Janicke I, Fischer DG, Stahl F, Helbig H, Hollwede H, Cragoe EJ, Jr., Keller SK, Wiederholt M. Regulation of cytoplasmic pH of cultured bovine corneal endothelial cel s in the absence and presence of bicarbonate. J Membr Biol. 1988;103:29-40 Helbig H, Korbmacher C, Stumpff F, Coca-Prados M, Wiederholt M. Na+/H+ exchange regulates intracellular pH in a cell clone derived from bovine pigmented ciliary epithelium. J. Helbig H, Korbmacher C, Kühner D, Berweck S, Wiederholt M. Characterization of Cl-/HCO -3 exchange in cultured bovine pigmented ciliary epithelium. Exp. Eye Res. 1988;47:515-523 Helbig H, Korbmacher C, Berweck S, Kühner D, Wiederholt M. Kinetic properties of Na+/H+ exchange in cultured bovine pigmented ciliary epithelial cells. Pflügers Arch. 1988;412:80-85 Helbig H, Korbmacher C, Berweck S, Kühner D, Wiederholt M. Culture of ciliary body epithelia and studies of ion transport. Fortschr Ophthalmol. 1988;85:42-45 Helbig H, Korbmacher C, Wiederholt M. K+-conductance and electrogenic Na+/K+ transport of cultured bovine pigmented ciliary epithelium. J Membr Biol. 1987;99:173-186 Wiese G, Ballowitz L, Korbmacher C. Pharmacokinetic studies of the enterohepatic circulation in Gunn rats. Klin Pädiatr. 1985;197:366-370 Korbmacher, C., Letz, B., Ackermann, A., Volk, T. (1995) Sodium channels and nonselective cation channels in the cortical collecting duct. Nephrology, Dialysis, Transplantation 10: 1546-1550. Loffing J., Korbmacher C. (2009) Sodium transport in the renal connecting tubule. Pflügers Archiv 458: 111-135. Contribution to books
Wiederholt, M., Helbig, H., Korbmacher, C. (1991) Ion transport across the ciliary epithelium: Lessons from cultured cells and proposed role of the carbonic anhydrase. In "Carbonic Anhydrase". Eds. F. Botrè, G. Gross, B.T. Storey, VCH, Weinheim, New York, Basel, Cambridge, pp. 232-244. Wiederholt, M., Helbig, H., Korbmacher, C. (1993) Regulation of electrolyte transport mechanisms in ciliary epithelium. In "Basic Aspects of Glaucoma Research III" Ed. E. Lütjen-Drecoll, Schattauer Verlag, Stuttgart-New York, pp. 225-241. Korbmacher, C., Barnstable, C. J. (1993) Renal epithelial cells show nonselective cation channel activity and express a gene related to the cGMP-gated photoreceptor channel. In "Nonselective cation channels: Pharmacology, Physiology and Biophysics", ed. by D. Siemen and J. Hescheler, Birkhäuser Verlag Basel/Switzerland, pp. 147-164. Beteiligt als Koautor am Lehrbuch ‚Physiologie’ (5. Auflage, 2005, Thieme-Verlag) herausgegeben von Rainer Klinke, Hans-Christian Pape und Stefan Silbernagl. Federführender Autor der Kapitel ‚Die Zel e als Grundbaustein’ und ‚Von der Zel e zum Organ’. Beteiligt als Koautor am Lehrbuch ‚Physiologie‘ (6. Auflage, 2010, Thieme-Verlag) herausgegeben von Rainer Klinke, Hans-Christian Pape, Armin Kurtz und Stefan Silbernagl. Federführender Autor des Kapitels ‚Funktion und Interaktion von Zel en‘ Beteililgt als Koautor am Lehrbuch ‚Physiologie‘ (7. Auflage, Thieme-Verlage, in Vorbereitung) herausgegeben von Hans-Christian Pape, Armin Kurtz und Stefan Silbernagl. Federfürhrender Autor des Kapitels ‚Funktion und Interaktion von Zel en‘ Promotion (Dr. med.)
'Einfluß von Milch und Milchbestandteilen auf die enterale Resorption von Bilirubin am Modell der Gunn-Ratte.' Dissertation an den Medizinischen Fachbereichen der FU Berlin, 1986. Habilitation in Physiology (Priv.-Doz.)
'Charakterisierung des Ionentransports einer differenzierten Zellinie (M-1) des Sammelrohrepithels mit Hilfe der 'Patch clamp'-Technik.' Vorgelegt dem Fachbereich Humanmedizin der Johann Wolfgang Goethe-Universität Frankfurt am Main, 1994.

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