SIGMA-ALDRICH Material Safety Data Sheet Date Printed: 10/SEP/2008 Date Updated: 02/MAY/2006 Version 1.4 Regulation (EC) No 1907/2006 1 - Product and Company Information Product Name NORFLOXACIN Product Number N9890 Company Sigma-Aldrich Pte Ltd #02-14 The Capricorn, Sci. Park II Singapore 117528 Singapore Technical Phone # (65) 6779 1200 Fax (65) 6779 1822 2 - Hazards Identification SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT Not hazardous according to Directive 67/548/EEC. 3 - Composition/Information on Ingredients Product Name CAS # EC no Annex I Index Number NORFLOXACIN 70458-96-7 274-614-4 None Formula C16H18FN3O3 Molecular Weight 319.3 AMU Synonyms AM-715 * Baccidal * 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazin yl)-3-quinolinecarboxylic acid * 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazin yl)-3-quinolinecarboxylic acid * MK-366 * Norfloxacin * 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3 -quinolinecarboxylic acid 4 - First Aid Measures AFTER INHALATION If inhaled, remove to fresh air. If breathing becomes difficult, call a physician. AFTER SKIN CONTACT In case of contact, immediately wash skin with soap and copious amounts of water. AFTER EYE CONTACT In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. AFTER INGESTION If swallowed, wash out mouth with water provided person is conscious. Call a physician.
5 - Fire Fighting Measures EXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. SPECIAL RISKS Specific Hazard(s): Emits toxic fumes under fire conditions. SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. 6 - Accidental Release Measures PROCEDURE(S) OF PERSONAL PRECAUTION(S) Exercise appropriate precautions to minimize direct contact with skin or eyes and prevent inhalation of dust. METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. 7 - Handling and Storage HANDLING Directions for Safe Handling: Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure. STORAGE Conditions of Storage: Keep tightly closed. Store at 2-8°C 8 - Exposure Controls / Personal Protection ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required. GENERAL HYGIENE MEASURES Wash thoroughly after handling. PERSONAL PROTECTIVE EQUIPMENT Respiratory Protection: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Hand Protection: Protective gloves. Eye Protection: Chemical safety goggles. 9 - Physical and Chemical Properties Appearance Physical State: Solid Property Value At Temperature or Pressure pH N/A BP/BP Range N/A MP/MP Range N/A SIGMA - N9890 www.sigma-aldrich.com Page 2
Flash Point N/A Flammability N/A Autoignition Temp N/A Oxidizing Properties N/A Explosive Properties N/A Explosion Limits N/A Vapor Pressure N/A SG/Density N/A Partition Coefficient N/A Viscosity N/A Vapor Density N/A Saturated Vapor Conc. N/A Evaporation Rate N/A Bulk Density N/A Decomposition Temp. N/A Solvent Content N/A Water Content N/A Surface Tension N/A Conductivity N/A Miscellaneous Data N/A Solubility N/A 10 - Stability and Reactivity STABILITY Stable: Stable. Materials to Avoid: Strong oxidizing agents. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen fluoride. HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur 11 - Toxicological Information RTECS NUMBER: VB2005000 ACUTE TOXICITY LD50 Oral Rat > 4000 mg/kg LD50 Subcutaneous Rat >1500 MG/KG LD50 Intravenous Rat 245 MG/KG Remarks: Behavioral:Somnolence (general depressed activity). Behavioral:Convulsions or effect on seizure threshold. LD50 Intramuscular Rat >500 MG/KG SIGMA - N9890 www.sigma-aldrich.com Page 3
Remarks: Behavioral:Convulsions or effect on seizure threshold. Lungs, Thorax, or Respiration:Other changes. LD50 Oral Mouse 4000 mg/kg LD50 Intraperitoneal Mouse 1064 MG/KG LD50 Subcutaneous Mouse >1500 MG/KG LD50 Intravenous Mouse 220 MG/KG Remarks: Behavioral:Convulsions or effect on seizure threshold. Behavioral:Somnolence (general depressed activity). LD50 Intramuscular Mouse 470 MG/KG Remarks: Behavioral:Somnolence (general depressed activity). LD50 Oral Mammal > 4000 mg/kg SIGNS AND SYMPTOMS OF EXPOSURE May cause nausea, headache, dizziness, lightheadedness, crystalluria, gastrointestinal or neurological adverse effects. ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: May be harmful if swallowed. CHRONIC EXPOSURE - MUTAGEN Human 160 MG/L Cell Type: lymphocyte DNA damage Rat 160 MG/KG Oral Micronucleus test Rat 310 UMOL/L SIGMA - N9890 www.sigma-aldrich.com Page 4
Cell Type: liver Unscheduled DNA synthesis CHRONIC EXPOSURE - TERATOGEN Species: Rat Dose: 1375 MG/KG Route of Application: Oral Exposure Time: (7-17D PREG) Result: Effects on Newborn: Behavioral. Specific Developmental Abnormalities: Musculoskeletal system. Species: Mouse Dose: 20 GM/KG Route of Application: Oral Exposure Time: (61D MALE/15D PRE-6D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Species: Mouse Dose: 10 GM/KG Route of Application: Oral Exposure Time: (61D MALE/15D PRE-6D PREG) Result: Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord). Species: Monkey Dose: 4650 MG/KG Route of Application: Unreported Exposure Time: (20-50D PREG) Result: Effects on Embryo or Fetus: Fetal death. CHRONIC EXPOSURE - REPRODUCTIVE HAZARD Result: Pregnant women should avoid contact with this material. Species: Rat Dose: 2750 MG/KG Route of Application: Oral Exposure Time: (7-17D PREG) Result: Effects on Newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4). Species: Mouse Dose: 1250 MG/KG Route of Application: Oral Exposure Time: (6-15D PREG) Result: Effects on Newborn: Behavioral. Species: Monkey Dose: 2 GM/KG Route of Application: Oral Exposure Time: (10-20D PREG) Result: Endocrine:Estrogenic. Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Maternal Effects: Other effects. Species: Rabbit Dose: 1625 MG/KG Route of Application: Oral Exposure Time: (13D PRE) Result: Maternal Effects: Uterus, cervix, vagina. Maternal SIGMA - N9890 www.sigma-aldrich.com Page 5
Effects: Ovaries, fallopian tubes. Species: Rabbit Dose: 1300 MG/KG Route of Application: Oral Exposure Time: (6-18D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Species: Rabbit Dose: 1300 MG/KG Route of Application: Oral Exposure Time: (6-18D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Species: Rabbit Dose: 1300 MG/KG Route of Application: Oral Exposure Time: (6-18D PREG) Result: Effects on Fertility: Litter size (e.g.; # fetuses per litter; measured before birth). Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death. 12 - Ecological Information No data available. 13 - Disposal Considerations SUBSTANCE DISPOSAL Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. 14 - Transport Information RID/ADR Non-hazardous for road transport. IMDG Non-hazardous for sea transport. IATA Non-hazardous for air transport. 15 - Regulatory Information Not hazardous according to Directive 67/548/EEC. COUNTRY SPECIFIC INFORMATION Germany WGK: 2 Self-Classification 16 - Other Information SIGMA - N9890 www.sigma-aldrich.com Page 6
WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. DISCLAIMER For R&D use only. Not for drug, household or other uses. SIGMA - N9890 www.sigma-aldrich.com Page 7
January 2010 Issue 23 Meat Safety News Digest A collection of recent news relevant to the safety of red meat prepared by the Food Safety Program of Meat & Livestock Australia, for SAFEMEAT Stakeholders PREVALENCE Results from the study showed that L. monocytogenes was present in both faecal The risk of Listeria monocytogenes and environmental samples, with grea
Bordetella in Squirrels In the last decade, rehabilitators have reported an increase required 21 days). Doxycycline is the antibiotic of choice for in the number of squirrels in rehabilitation dying dogs and cats and may be used in rabbits, squirrels, and unexpectedly and suddenly with few symptoms and no other rodents. Nebulizers were also used for some cases. obvious causes such as tra