Tadalafil appartiene alla classe degli inibitori selettivi della fosfodiesterasi di tipo 5, con un profilo farmacocinetico caratterizzato da un’emivita terminale di circa diciotto ore. Dopo somministrazione orale viene assorbito rapidamente e raggiunge concentrazioni plasmatiche massime in due ore. La biotrasformazione avviene principalmente tramite CYP3A4 con formazione di metaboliti inattivi, escreti in prevalenza con le feci. L’elevato legame alle proteine plasmatiche (>90%) assicura una distribuzione stabile. Nei confronti delle altre molecole della stessa classe, cialis compresse italia è noto per la durata prolungata dell’attività farmacologica.
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Analyses of adverse events during apheresis with focus on substitution fluids. The Swedish registryRut Norda1, Ulla Axdorph2, Claes-Göran Axelsson3, Gösta Berlin4, Svante Jonsson5, Gunilla Kumlien6, Jan Kurkus7, Bernd Stegmayr8, Björn Wikström91. Dept. of Clin. Imm. & Transfusion Medicine, Uppsala; 2. Dept. of Clin Imm. & Transfusion Medicine, Solna; 3. Dept. of Transfusion Medicine, Örebro; 4. Dept. of Transfusion Medicine, Linköping; 5. Dept. of Nephrology & Transplantation, Malmö;
6. Dept. of Transfusion Medicine, Karolinska, Huddinge; 7. Dept. of Nephrology, Lund; 8. Dept. of Nephrology, Umeå; 9. Dept. of Nephrology, Uppsala. The AEs below represent data from 2000-2001. Only symptoms and signs are reported here - Grade 1, n=40; Grade 2 and 3 n=96. AEs w i t h s u b s t i t u t i o n f l u i d a l b u m i n v e r s u s p
•There is a decrease in reported adverse events grade II/III over the years. •In parallel there is a decrease in procedures performed for diagnoses more vulnerable for AEs.
•When using albumin as substitution fluid hypotension is more frequent while urticaria and
shivering are more common AEs using plasma. This will be further analyzed. AEs with substitution of albumin vrs plasma + albumin Various diagnoses and i n c i d e n c e Adverse events grade 2/3 procedures) (symptoms and signs) Guillain-Barre Goodpasture Tx-rejection Myasthenia gravis Vasculitis Wegeners Severe sepsis Material: Data from 1996-2001 has Hyperviscosity Percentage of all Hypercholesterolemi Urticaria Hypotension Shivering
not been included since the transition to
computerization has led to a delay in the
Number of p r o c e d u r e s r e l a t e diagnoses with Adverse Events a b o v e a v e r a g e AEs with use of liquid stored plasma (LSP) + albumin v e r s u s f r e s h f r o z e n p l a s m a ( F F P ) + a l b u m i Guillain-Barr Goodpasture . procedures Tx-rejection Hypotension Tingling AE grade II/III (signs and symptoms only) in 8 apheresis units. The total number (n) of TPE procedures 1996-2001 at each unit are given. Number of procedures related to d i a g n o s e s Grade of AE in relation to substitution fluids Unit F: n=1731 with Adverse Events below average Unit C: n=1040 Unit H: n=1982 Unit E: n=1683 Unit B: n=384 Myasthenia Unit A: n=271 Vasculitis Unit G: n=1809 Wegeners Septic shock Unit D: n=1299 Hyperviscosity No. procedures Hypercholesterolemia alb 3.5-5% LSP+alb A d v e r s e e v e n t s , % Substitution fluids
AE grade 3/III: treatment required and procedure stopped
1.0 TITLE PAGE FOR 2008 PILOT (STOP-FLU 2) Study title: A pilot study for a randomized controlled trial comparing trivalent split virus influenza vaccine to seasonal antiviral prophylaxis in healthcare workers and other healthy adults: assessment of zanamivir versus vaccine. Products to be used: 1. Licensed, trivalent split virus influenza vaccine (Vaxigrip®, Fluviral®) 2. Zanamivir (R
TEXTE COURT DU RAPPORT D’ÉVALUATION TECHNOLOGIQUE Octobre 2013 Service évaluation des actes professionnels Ce texte court est téléchargeable sur : Haute Autorité de Santé Service documentation – information des publics 2, avenue du Stade de France – F 93218 Saint-Denis La Plaine CEDEX Tél. : +33 (0)1 55 93 70 00 – Fax : +33 (0)1 55 93 74 00 Ce texte court a été va