Tadalafil appartiene alla classe degli inibitori selettivi della fosfodiesterasi di tipo 5, con un profilo farmacocinetico caratterizzato da un’emivita terminale di circa diciotto ore. Dopo somministrazione orale viene assorbito rapidamente e raggiunge concentrazioni plasmatiche massime in due ore. La biotrasformazione avviene principalmente tramite CYP3A4 con formazione di metaboliti inattivi, escreti in prevalenza con le feci. L’elevato legame alle proteine plasmatiche (>90%) assicura una distribuzione stabile. Nei confronti delle altre molecole della stessa classe, cialis compresse italia è noto per la durata prolungata dell’attività farmacologica.

Navynews.co.uk

NAVY NEWS
Paper Rates (1 April 2013)
National and International circulation
Display Fixed Size Adverts:
A: Full Page
£3,032 ex VAT
Navy News, the newspaper of the Royal Navy since 1954,
B: 1/2 Page Horizontal
£1,713 ex VAT
has a monthly circulation of up to 30,000.
C: 1/2 Page Vertical
£1,713 ex VAT
Ex-pat communities and ex-Service Associations use
D: 1/4 Page
£910 ex VAT
its columns to keep in touch with present developments
E: 1/8 Page
£465 ex VAT
and old shipmates, while foreign embassies and Press
F: 1/4 Page Banner
Correspondents scan its pages regularly, picking up
items they have missed through the usual lines of
G: 1/8 Page Banner
£465 ex VAT
communication.
H: 100mm Banner
£1,264 ex VAT
J: 50mm Banner
£657 ex VAT
Month by month it features RN operations, developments
in ships and naval aviation, organisational changes,
K: 10mm Slug
£124 ex VAT
charitable works, sports, historical features and book
reviews, reflecting the wide range of its readership
Display Columns:
Per 10mm (Min 30mm)
Over 10,000 copies of Navy News are sold directly via
newsagents across the country, 5,500 go to subscribers
Classified Columns:
and a further 13,000 are distributed within the Royal Navy
to ships and shore establishments.
Per 10mm (Min 30mm)
Run-on adverts (Min 30 words) £1.00 per word
Where readers may differ in location, analysis of the
subscriber base suggests people are time rich and have
a high disposable income. Key interests and hobbies
Inserts:
include holidays, charity, equity release, outdoor pursuits,
Leaflets
£25.00 per 1000
motoring, private education and property.
Leaflets (Subscribers only)
£85.00 per 1000
Whatever your product or service, your advertisement will
target a welcoming audience.
Discounts:
Our advertising team is waiting for your call and we can
Agency and series discounts are available on application.
assure you that the same high standards of customer
care which have applied over the years will continue.
Conditions of Acceptance:
Your best interests are our prime concern. Let us help
you to make the most of your company, its products and
Navy News reserves the right to refuse to publish any
services.
advertisement offered for publication or any copy for any
advertisement for which an order has been accepted.
Navy News does not guarantee the insertion of any
Telephone: +44(0)23 9272 5062
advertisement in any specified issue and will not accept
liability for any loss occasioned by failure to publish an
advertisement from any cause whatever.
+44(0)23 9273 4448
Navy News reserves the right to make any amendments
that it considers necessary and will not be liable for any
[email protected]
errors or omissions.
Description of goods for sale or services offered in
navynews.co.uk/advertise
advertisements must comply with the requirements of the
Trades Description Act.
The Advertiser will indemnify the Proprietor, the
Representatives and the Printer of the journal against any
damages which they may sustain in consequence of the
publication of his advertisement.
Notice of cancellation must be received in writing 5 weeks
preceding publication date.
Payments:
First three payments required in advance from all
advertisers. The first payment from a new advertising
agency is required in advance.
Approved Accounts: Payment required within 30 days of
invoice.
Payments accepted by cheque, debit/credit card or BACS
(details available on request).
NAVY NEWS
Website Rates (1 April 2013)
National and International circulation
Advert Types:
For our banner and skyscraper advertisements, we use a
The internet offers advertisers a unique opportunity
traffic scheduling system that circulates them at an even
to keep messages fresh and up-to-date and to display
rate to ensure that they receive fair and equal rotation.
products and services to the mass market.
Banners are a great vehicle for creating brand awareness
Ex-pat communities and ex-service associations
and for driving traffic to your site.
browse the Navy News website to keep in touch with
The dimensions are 550 pixels wide by 60 pixels high and
present developments and old shipmates, while foreign
should have a resolution of 72dpi.
embassies and Press Correspondents scan its pages,
The file should be in either GIF or Animated GIF
regularly picking up items they have missed through the
usual lines of communication.
The cost per month for this is: £80.00 ex VAT
The internet allows you to communicate a deeper
The latest advertising option is the Skyscraper.
message – a one-to-one relationship with customers who
This advert will be available on every page of the website
(in rotation) and can be linked to your email address or
interact and respond 24hrs a day, 365 days a year.
website.
The dimensions are 150 pixels wide x 600 pixels high and
The Navy News website is the online newspaper for the
should have a resolution of 72dpi.
Royal Navy.
The file should be in either GIF or Animated GIF
The same award winning editorial team write for both the
The cost per month for this is £130.00 ex VAT
printed and online publications.
All artwork will need to be emailed to:
Navy News Online benefits from this close association
[email protected]
with the newspaper; the reputation, goodwill and brand
recognition enjoyed by the paper has allowed the website
in a GIF or animated GIF file.
to gather a large audience over a relatively short period.
Our advertising team is waiting for your call and we can
Promoting your company through Navy News Online
assure you the same high standards of customer care,
allows you, the advertiser, to target a clearly defined
which has been applied over the years, will continue.
international market.
Your best interests are our prime concern. Let us help
you to make the most of your company, its products and
services.
Telephone: +44(0)23 9272 5062
+44(0)23 9273 4448
[email protected]
navynews.co.uk/advertise
Navy News Advertising Card
Display Fixed Size Adverts
A: Full Page
B: 1/2 Page Horizontal
C: 1/2 Page Vertical
Height: 338mm
Width: 264mm
Height: 168mm
Width: 264mm
Height: 338mm
Width: 130mm
D: 1/4 Page
E: 1/8 Page
Height: 168mm
Width: 130mm
Height: 80mm
Width: 130mm
F: 1/4 Page Banner
G: 1/8 Page Banner
H: 100mm Banner
Height: 80mm
Width: 264mm
Height: 40mm
Width: 264mm
Height: 100mm
Width: 264mm
J: 50mm Banner
K: 10mm Slug
Height: 50mm
Width: 264mm
Height: 10mm
Width: 264mm
Display Columns
Columns
Maximum column height: 338mm
Minimum column height: 30mm
Height: in mm
Width: in mm
Classified Columns
Columns
163mm 197mm 230mm 264mm
Maximum column height: 338mm
Minimum column height: 30mm
Height: in mm
Width: in mm
Production Overview
Advert Production Service:
Resolution:
Unique Reference Numbers (URNs)
If your copy is ready in good time and
All bitmap images for Colour and Mono
are allocated to every advertisement
you are unable to supply a completed
should be a minimum 300dpi at the
booked, these seven-digit numbers
advertisment, our in-house Graphic
used size.
enable us to identify the files received
Design service is available to create
and match them to the page.
your advertisements.
File Type:
Always start your filename with
This service however offers a limited
All files must be in PDF/X-1a:2001
this number, and use it in all
choice of typefaces and a single proof.
format with all fonts embedded, or
correspondence to make it easier to
JPEG, minimum 300dpi at the used
identify your artwork and minimise the
Please ensure you make this
potential for errors.
requirement clear when you make
your booking, so your advert can be
File Dimensions:
Classified or Display?:
correctly processed.
All files should be created to the exact
Your advertising executive will explain
Copy deadlines:
dimensions of the booked space.
the different sizes available.
Space for advertisements not received
Please do not include Bleed, Crop
These adverts differ in sizing and costs, by the copy deadline will be charged
Marks or additional white space.
and Classified Adverts will ONLY run
File Delivery:
in the Classified section of Navy News.
If you are not sure, please ask your
All files should be sent to:
Advertising Executive.
[email protected] and copied
to [email protected]

Source: https://navynews.co.uk/assets/upload/files/2014%20NN%20Advertising%20Rate%20Card-3.pdf