Vital signs – prn to evaluate “End-of-Life Vital Signs” for comfort, heart rate (tachycardia), respiration (apnea, rapid rate/tachypnea), temperature if warm to touch, secretions (gurgling or coarse crackles). Diet – Patient choice of time, quantity and type of food as tolerated. Family may provide food. Activity – as tolerated. Position of comfort. Oxygen – 2 to 3 L/minute/nasal cannula prn shortness of breath (dyspnea). Pain: Optimal pain management is best achieved with routine or long-acting medication, such as Morphine, Dilaudid, Oxycontin, Duragesic, etc. with a routine dosage schedule. Breakthrough pain, identified by verbalization, moaning, restlessness, grimacing, etc, is treated with a short-acting oral medication, such as Roxanol or Dilaudid liquid prn for breakthrough pain, shortness of breath, restlessness, agitation, cough. Note: many residents are unable to ask for prn medications; observe for signs of discomfort. Anxiety, dyspnea, agitation or restlessness – Ativan Intensol 2 mg/ml – small dose sublingual or oral, prn agitation, anxiety, shortness of breath (may be beneficial on a regular basis for symptoms or to augment pain control). Secretions – Scopolamine patch 1.5 mg – apply one to two patches q 72 hours prn secretions, and/or Glycopyrrolate 1 mg po TID prn secretions, and/or Atropine 1% ophthalmic 1 to 2 drops SL q 6 hours prn secretions. Constipation (prevention is key) – DSS 100mg or 250mg 1 to 2 BID Plus Senna 1 to 2 po BID, or Sorbitol 30 ml po daily or BID prn constipation. If severe, Lactulose 15 to 30 ml BID to TID. Nausea – PRN orders for compazine or phenergan. Ativan prn helps nausea. Agitation with psychosis, delirium – Haldol sublingual (SL) prn hallucination, confusion, severe restlessness. California POLST Education Program: Comfort Care Measures Overview
March 2012 Coalition for Compassionate Care of California
Materials made possible by a grant from the California HealthCare Foundation
End-of-Life Vital Signs:
“Routine vital signs” are usually discontinued when death is near and focus
o Machinery to assess routine vital signs may cause patient or family
o Information from routine vital signs, like respiratory rate and oxygen
saturation, are usually not helpful and may cause confusion about treatments.
“End-of-life vital signs” help assess comfort.
o Heart rate (apical pulse with stethoscope or palpated radial pulse) to
evaluate if tachycardia, often a sign of discomfort in the unconscious patient).
o Respirations, looking at quality and character, such as irregular or
apneic spells which show approaching death.
Note: Opioids should not be held for slow, shallow respirations in the dying patient.
o Secretions, wet respirations (gurgling, rattling, crackling) caused by
pooling of oral secretions, can be treated.
o Peripheral perfusion, inspecting/palpating extremities to evaluate
mottling and cooling, which are signs that death is near.
o Temperature, sweating and fever are common at the end of life and
can be treated with acetaminophen, removal of blankets, fan, etc.
Key Points to “Honor Wishes for Comfort”:
Relief of distressing symptoms and pain can improve comfort and quality of
Medications are often required to relieve symptoms in the last days or hours
Medications are to reduce pain and suffering, not to hasten death.
The patient is dying from the medical illness, not the medications.
Educating and supporting families can reduce suffering and distress during
their loved one’s death and afterwards.
California POLST Education Program: Comfort Care Measures Overview
March 2012 Coalition for Compassionate Care of California
Materials made possible by a grant from the California HealthCare Foundation
Page 1 of 3 WARFARIN Why is this medication prescribed? Warfarin is used to prevent blood clots (thrombosis) from forming or growing larger in the arteries or veins. Warfarin has an anticoagulant effect on the blood. It slows down the clotting process helping to prevent thrombosis from occurring or reoccurring. Blood clots can lead to stroke, heart attack o
Biochemical and Biophysical Research Communications 291, 1302–1308 (2002) doi:10.1006/bbrc.2002.6607, available online at http://www.idealibrary.com onMetformin Effects on Dipeptidylpeptidase IV Degradationof Glucagon-like Peptide-1¨ hn-Wache,† Torsten Hoffmann,† Raymond A. Pederson,*Christopher H. S. McIntosh,* and Hans-Ulrich Demuth†,1† Probiodrug Research, Biocenter, Weinbe