Curriculum vitae

CURRICULUM VITAE
DATE AND PLACE OF BIRTH: December 25th, 1963, Siena, Italy.
ADDRESS: Via E.S. Piccolomini, 63 - 53100 SIENA - ITALY.
(office): +39-0577-234438(lab): +39-0577-234455/6fax: +39-0577-234446e-mail: [email protected] EDUCATION:
• 1982 - High School Diploma (Liceo Scientifico, Siena, Italy).
• 1991 - Degree in Pharmaceutical Chemistry and Technology (Pharmacy), University of Siena, Italy, 110/110 cum laude, with experimental thesis: "Antioxidant phenol derivatives: calcium antagonistic properties and interaction with mitochondrial oxidative phosphorylation".
1995 - Ph.D. in Pharmaceutical Sciences, with a Scholarship from the Italian Ministry of the University and the Scientific Research (MURST), in the Institute of Pharmacological Sciences, University of Siena, Italy.
• English: written, read (7 years).
RESEARCH EXPERIENCE:
1989-present - Institute of Pharmacological Sciences, Department of Biomedical Sciences, Department of Neurosciences, Department of Life Sciences, University of Siena, Italy. Prof. G. Sgaragli's laboratory. Experimental research on novel natural as well synthetic modulators of ionic currents in smooth muscle cells (patch-clamp technique), in vitro antioxidant properties of some phenol derivatives, cyclooxygenase activity of hemoglobin and peroxidases, interaction of taurine and related compounds with mitochondrial oxidative phosphorylation.
FELLOWSHIPS ABROAD:
Oct./Dec. 1989 - Department of Biochemistry, Trinity College, Dublin, Ireland. Dr. T. Mantle's laboratory. Studies on biochemical enzymology. ERASMUS Fellowship (ICP-89-I-0062, EU).
Nov. 1990/Jan. 1991 - Department of Biochemistry, Trinity College, Dublin, Ireland. Dr. M.P. Murphy's laboratory. Studies of the interaction of antioxidant phenol derivatives with mitochondrial oxidative phosphorylation. ERASMUS Fellowship (ICP-90-I-0072/12, EU).
Feb./Apr. 1993 - Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. Prof. K.K. Boev's laboratory. Studies on the interaction of some antioxidant phenol derivatives with smooth muscle cells. TEMPUS Fellowship (JEP-0789-92/93 EU).
Nov. 1993/May 1994 - Research Associate at the Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, IL, USA. Prof. E. Giacobini's laboratory. Studies on CNS concerning the development of new drugs for the treatment of patients affected by Alzheimer's disease.
Mar./Sep. 1995 - Research Associate at the Department of Pharmacology, University of Cambridge, U.K. Dr. B.A. Callingham's laboratory. Studies on semicarbazide-sensitive amino oxidases in deer digital artery and mesanglial cell; studies on adenosine receptors in guinea pig aorta.
FELLOWSHIPS IN ITALY:
May/Oct. 1991 - Convention with the Department of historical-social and philosophic stud-ies, University of Siena, Italy.
• Feb./Mar. 1995 - Research Associate in the Institute of Pharmacological Sciences, Nov. 1995 - Contract at the Institute of Pharmacological Sciences, University of Siena, Italy.
• Jan./Mar. 1996 - Research Associate at the Institute of Pharmacological Sciences, University of Siena, Italy. Project BIOMED I (Eurotaurine: regulation and function of taurine in the mammalian central nervous system. BMH1-CT94-1402).
• Apr. 1996/Mar. 1998 - Research Fellowship from the University of Siena.
• Aug 1997/Gen. 1999 - Technical assistant in the Institute of Pharmacological Sciences, University of Siena, Italy, under the joint project Italy-Bulgaria entitled “Chemical and physiopathological relationships in cerebral ischaemia: development of new therapeutic strategies”.
• Feb. 1999 - Oct. 2002"Assegno di Ricerca per l'Area Scientifica Farmacologica" (D.R. n. 449 del 21-7-1998) in the Institute of Pharmacological Sciences, University of Siena, Italy.
Feb. 2001 - Department of Neuroscience, Physiology Section, University of Turin, Italy. Prof. E. Carbone's laboratory. Studies on Ca2+ currents (single channel) with the patch-clamp technique in smooth muscle as well as neuroendocrine cells.
• Nov. 2002 – Researcher at the University of Siena, Italy.
HONOURS:
• Dic. 1996 - Member of the Italian Pharmacological Society.
• Nov. 1997 - Qualified as Technical assistant - VII qualification (D.R. n.362, 29.4.1997 - G.U. n.39 (4° serie speciale) 20.5.1997).
Nov. 2004 - Dec. 2012 – Member of Comitato per la Didattica del Corso di Laurea in Chimica e Tecnologia Farmaceutiche.
• Referee for Biochemical Pharmacology, Journal of Pharmacological Sciences, Pharmacological Research, Pharmacology, Journal of Pharmacy and Pharmacology, Life Sciences.
INVITED LECTURES:
Jun. 2012 - The Hyacinthaceae: Chemistry, Pharmacology, Taxonomy and Ethnobotany. An International, Multidisciplinary Symposium. 14th June - 15th June 2012, University of Surrey, Guildford, United Kingdom.
TEACHING:
Oct. 1993 - Lecturer at the "Training Course in Biochemical Pharmacology", Certosa di Pontignano, Siena, Italy (COMETT Programme, EU).
May 1999 - Lecturer at the "Recent advances in Neurobiology", Istituto di Scienze Farmacologiche, University of Siena, Italy (Programme SOCRATES, European Union).
2000/2001: - Module "Farmacologia dei Canali Ionici" (n.° 6 ore) (Course: Farmacologia e Farmacoterapia I; Degree in Pharmacy).
2001/2002: - Module "Farmacologia dei Canali Ionici" (n.° 10 ore) (Course: Farmacologia e Farmacoterapia I; Degree in Pharmacy).
2001/2002: - Module "Standardizzazione Biologica dei Farmaci" (n.° 10 ore) (Course: Farmacologia e Farmacoterapia I; Degree in Pharmacy).
2002/2003: - Statistica applicata alla ricerca biomedica (Course: Esercitazioni di statistica; Degree in Tecniche erboristiche, Farmacia, Controllo di qualità nel settore industriale farmaceutico, Scienza e tecnologia dei prodotti cosmetici).
2004: - Lecturer at the Training course “Terapia convenzionale e nuove classi di farmaci nel trattamento dell’ipertensione”, Sala Euclide, Matera, Italy, March 13-14, 2004.
2007-2010: - Principi di statistica e interpretazione scientifica dell’analisi statistica (Ph.D. school in Physiology, pharmacology, molecular and cellular toxicology).
2003/present: - Saggi e Dosaggi Farmacologici (Corso di Laurea in Chimica e Tecnologia Farmaceutiche); 2003/present: - Statistica Medica (Master Avanzato di II livello in Scienza e Tecnologia Cosmetiche).
UPERVISION OF Ph .D
. STUDENTS
Jan. 2007 - Dr. Donata Iozzi (Doctor europæus), Doctorate in physiology, pharmacology, molecular and cellular toxicology, XIX cycle. Title: Analysis of the mechanisms underlying the vasorelaxant action of two natural related flavonoids: quercetin and (+/-)-naringenin.
Feb. 2008 - Dr.ssa Caterina Lacava (Doctor europæus), Doctorate in physiology, pharmacology, molecular and cellular toxicology, XX cycle. Title: Pharmacological profile of 3,5-di-t-butylcatechol in the mammalian skeletal muscle and its use in the diagnosis of malignant hyperthermia.
Feb. 2009 - Dr.ssa Antonella Ferrara, Doctorate in physiology, pharmacology, molecular and cellular toxicology, XXI cycle. Title: Effect of de-alcoholated red wine in isolated rat heart: protective action in myocardial ischemia-reperfusion injury.
Nov. 2012 - Dr. Paolo Mugnai, Doctorate in physiology, pharmacology, molecular and cellular toxicology, XXV cycle. Title: The flavonoid quercetin stimulates the vascular smooth muscle Cav1.2 current: new insight into its mechanism of action.
Nov. 2013 - Dr.ssa Miriam Durante, Doctorate in physiology, pharmacology, molecular and cellular toxicology, XXVI cycle. Provisional title: Studio dei potenziali effetti vascolari di estratti di piante medicinali vietnamite.
RESEARCH PROJECT FUNDED
Agency: Italian Ministry of Foreign Affairs - Executive programme of scientific and technological co-operation between Italy and South Africa. Period: 2005-2007. Title: "Investigations of isolates from the Hyacinthaceae family for cardiovascular activity". Principal investigators: Dr. Fabio Fusi, Ph.D., and Prof. Dulcie Mulholland, University of KwaZulu-Natal, South Africa.
For the exchange of researchers Agency: Italian Ministry of Foreign Affairs - Significant research projects selected within the frame of the IV Executive programme of scientific and technological co-operation between Italy and Vietnam. Period: 2009-2011. Title: "Discovery of novel cardiovascular active agents from selected Vietnamese medicinal plants ". Principal investigators: Dr. Fabio Fusi e Dr. Nguyen Hai Nam, Hanoi University of Pharmacy, Vietnam.
Year 2010: € 35.000.
Year 2011: € 30.000.
Agency: Italian Ministry of Foreign Affairs - Significant research projects selected within the frame of the II Executive programme of scientific and technological co-operation between Italy and Slovakia. Period: 2009-2011. Title: "Molecular mechanisms underlying the cardiovascular and neuronal protective effects of a flavonoid-rich diet". Principal investigators: Dr. Fabio Fusi e Dr. Lubica Lacinova, Slovak Academy of Sciences, Institute for Molecular Physiology and Genetics, Slovakia.
Contract for research project with Rottapharm S.p.A. Title: “Effect of Andolast on KCa3.1 currents in RBL-2H3 cells”.
Year 2010: € 5.500.
COURSES:
June 15, 1992 - Mini Course on "Reactive species in vascular injury", Prof. Bruce A. Freeman, Institute "Mario Negri", Milan, Italy.
Sept. 5-9, 1994 - XIV Advanced Course in Pharmaceutical Chemistry: i) "Cerebral ischemia: new therapeutical approaches"; ii) "Carbohydrates: glycotecnologies and drug design". University of Urbino, Italy.
Ph.D. THESIS
Derivati fenolici di origine naturale o sintetici con proprietà antiossidanti e calcioantagonistiche come farmaci per la prevenzione dei danni tessutali da ischemia-riperfusione PUBLICATIONS
1) Fusi F., Valoti M., Sgaragli G.P. and Murphy M.P. (1991). The interaction of antioxidants
and structurally related compounds with mitochondrial oxidative phosphorylation. Methods
Find. Exp. Clin. Pharmacol., 13 (9), 599-603.
2) Fusi F., Sgaragli G.P. and Murphy M.P. (1992). Interaction of butylated hydroxyanisole
with mitochondrial oxidative phosphorylation. Biochem. Pharmacol., 43 (6), 1203-1208.
3) Sgaragli G.P., Valoti M., Fusi F., Palmi M., Mantovani P., De Santi M.M., Lorenzini L.
and Tosi P. (1993). Toxic injury to rat gut musculature following intraperitoneal administration
of 2-t-butyl-4-methoxyphenol. Eur. J. Pharmacol., 248, 121-129.
4) Sgaragli G.P., Valoti M., Gorelli B., Fusi F., Palmi M. and Mantovani P. (1993). Calcium
antagonist and antiperoxidant properties of some hindered phenols. Br. J. Pharmacol., 110,
369-377.
5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M. and
Sgaragli G.P. (1994). Cyclooxygenase activity of hemoglobin. Methods Enzym., 231, 562-573.
Hemoglobins, Part B. J. Everse Eds., Academic Press.
6) Silvestri R., Pagnozzi E., Valoti M. and Fusi F. (1994). Non-steroidal antiinflammatory
agents. Synthesis and enzyme inhibition of 2-[4-(heteroarylmethyl)phenil] propanoic acids and
analogues. Il Farmaco, 49 (10), 625-632.
7) Mori F., Lai C., Fusi F. and Giacobini E. (1995). Cholinesterase inhibitors increase
secretion of APPs in rat brain cortex. NeuroReport, 6, 633-636.
8) Petkov G., Fusi F., and Boev K.K. (1995). Effects of cyclopiazonic acid on the phasic and
tonic contractions in the smooth muscles of the guinea-pig and cat stomach. Compt. Rend.
Bulg. Acad. Sci., 48 (8), 57-60.
9) Palmi M., Fusi F., Youmbi G., Frosini M., Bianchi L., Della Corte L., Sgaragli G.P. and
Tipton K.F. (1996). Effects of taurine and structurally-related analogues on Ca2+-uptake and
respiration rate in rat liver mitochondria. Adv. Exp. Med. Biol., 403, 117-124.
10) Fusi F., Marazova K., Pessina F., Petri C. and Sgaragli G.P. (1997). Can food
antioxidants prevent cancer and cardiovascular diseases? Acta Phytotherapeutica, 3, 10-20.
11) Palmi M., Youmbi G., Fusi F., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and
Tipton K.F. (1998). Antagonism by taurine on the ruthenium red-induced and 6-
hydroxydopamine plus 1-methyl-4-phenylpyridinium-induced Ca2+ release from rat liver
mitochondria. Adv. Exp. Med. Biol., 442, 91-98.
12) Fusi F., Gorelli B., Valoti M., Marazova K. and Sgaragli G.P. (1998). Effects of 2,5-di-t-
butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle. Eur. J. Pharmacol., 346,
237-243.
13) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1998). Myorelaxant activity
of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus. Eur. J. Pharmacol., 360,
43-50.
14) Fusi F., Valoti M., Frosini F. and Sgaragli G.P. (1999). 2,5-Di-t-butyl-1,4-
benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta. Eur. J.
Pharmacol., 366, 181-187.
15) Frosini M., Sesti C., Valoti M., Palmi M., Fusi F., Parente L. and Sgaragli G. (1999).
Rectal temperature and prostaglandin E2 increase in cerebrospinal fluid of conscious rabbits
after intracerebroventricular injection of hemoglobin. Exp. Brain Res., 126, 252-258.
16) Palmi M., Youmbi G., Fusi F., Sgaragli G.P., Dixon H.B.F., Frosini M. and Tipton K.F.
(1999). Potentiation of mitochondrial Ca2+ sequestration by taurine. Biochem. Pharmacol., 58,
1123-1131.
17) Palmi M., Tchuisseu Youmbi G., Sgaragli G.P., Meini A., Benocci A., Fusi F., Frosini M.,
Della Corte L., Davey G. and Tipton K.F. (2000). The mitochondrial permeability transition
and taurine. Adv. Exp. Med. Biol., 483, 87-96.
18) Frosini M., Sesti C., Palmi M., Valoti M., Fusi F., Mantovani P., Bianchi L., Della Corte
L. and Sgaragli G.P. (2000). The possible role of taurine and GABA as endogenous cryogens
in the rabbit. Adv. Exp. Med. Biol., 483, 335-344.
19) Valoti M., Fusi F., Frosini M., Pessina F., Tipton K.F. and Sgaragli G.P. (2000).
Cytochrome P450-dependent N-dealkylation of l-deprenyl in C57BL mouse liver microsomes:
effects of in vivo pretreatment with ethanol, phenobarbital, β-naphthoflavone and l-deprenyl.
Eur. J. Pharmacol., 391, 199-206.
20) Fusi F., Marazova K., Pessina F., Gorelli B., Valoti M., Frosini M. and Sgaragli G.P.
(2000). On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta
rings. Eur. J. Pharmacol., 394, 109-115.
21) Frosini M., Sesti C., Palmi M., Valoti M., Fusi F., Mantovani P., Bianchi L., Della Corte
L. and Sgaragli G. (2000). Heat-stress-induced hyperthermia alters CSF osmolality and
composition in conscious rabbits. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 279,
R2095-R2103.
22) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (2001). Effects of some sterically
hindered phenols on whole-cell Ca2+ current of guinea pig gastric fundus smooth muscle cells.
Br. J. Pharmacol., 132, 1326-1332.
23) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (2001). 2,5-Di-t-butyl-1,4-
benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion
generation. Br. J. Pharmacol., 133, 988-996.
24) Pessina F., Kalfin R., Esposito L., Fusi F., Valoti M., Ponticelli F. and Sgaragli G. (2001).
Neuroprotection afforded by some hindered phenols and α-tocopherol in guinea-pig detrusor
strips subjected to anoxia-glucopenia and reperfusion-like conditions. Naunyn Schmiedeberg's
Arch. Pharmacol., 364, 462-471.
25) Petkov G.V., Fusi F., Saponara S., Gagov H., Sgaragli G.P. and Boev K.K. (2001).
Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells
from rat tail main artery. Acta Physiol. Scand., 173, 257-265.
26) Fusi F., Tzankova V., Valoti M., Pessina F. and Sgaragli G.P. (2001). 3,5-Di-t-butyl-4-
hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca2+-
ATPase. Biochem. Pharmacol., 62, 1613-1619.
27) Saponara S., Sgaragli G. and Fusi F. (2002). Quercetin as a novel activator of L-type Ca2+
channels in rat tail artery smooth muscle cells. Br. J. Pharmacol., 135, 1819-1827.
28) Fusi F., Saponara S., Sgaragli G., Cargnelli G. and Bova S. (2002). Ca2+ entry blocking
and contractility promoting actions of norbormide in single rat caudal artery myocytes. Br. J.
Pharmacol., 137, 323-328.
29) Fusi F., Saponara S., Pessina F., Gorelli B. and Sgaragli G. (2003). Effects of quercetin
and rutin on vascular preparations. A comparison between mechanical and electrophysiological
phenomena. Eur. J. Nutr., 42, 10-17.
30) Bova S., Cavalli M., Cima L., Luciani S., Saponara S., Sgaragli G., Cargnelli G. and Fusi
F. (2003). Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular
smooth muscles. Eur. J. Pharmacol., 470, 185-191.
31) Valoti M., Frosini M., Dragoni S., Fusi F., and Sgaragli G.P. (2003). Pharmacokinetics of
diphenhydramine in healthy volunteers with a dimenhydrinate 25 mg chewing gum formulation.
Methods Find. Exp. Clin. Pharmacol., 25, 377-381.
32) Fusi F., Saponara S., Frosini M., Gorelli B. and Sgaragli G. (2003). L-type Ca2+ channels
activation and contraction elicited by myricetin on vascular smooth muscles. Naunyn
Schmiedeberg's Arch. Pharmacol., 368, 470-478.
33) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G. and
Fusi F. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7)
as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle
contractility. Br. J. Pharmacol., 141, 415-422.
34) Fusi F., Iozzi D., Sgaragli G. and Frosini M. (2005). 3,5-Di-t-butylcatechol (DTCAT) as
an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC). Biochem.
Pharmacol., 69, 485-491.
35) Fusi F., Sgaragli G. and Saponara S. (2005). Mechanism of myricetin stimulation of
vascular L-type Ca2+ current. J. Pharmacol. Exp. Ther., 313, 790-797.
36) Fusi F., Saponara S., Valoti M., Dragoni S., D’Elia P., Sgaragli T., Alderighi D., Kawase
M., Shah A., Motohashi N. and Sgaragli G. (2006). Cancer cell permeability-glycoprotein as a
target of MDR reverters: possible role of novel dihydropyridine derivatives. Curr. Drug
Targets, 7, 949-959.
37) Carosati E., Cruciani G., Chiarini A., Budriesi R., Ioan P., Spisani R., Spinelli D.,
Cosimelli B., Fusi F., Frosini M., Matucci R., Gasparrini F., Ciogli A., Stephens P.J. and
Devlin F.J. (2006). Calcium channel antagonists discovered by a multidisciplinary approach. J.
Med. Chem., 49, 5206-5216.
38) Saponara S., Testai L., Iozzi D., Martinotti E., Martelli A., Chericoni S., Sgaragli G., Fusi
F. and Calderone V. (2006). (+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa)
channel opener in vascular smooth muscle cells. Br. J. Pharmacol., 149, 1013-1021.
39) Fusi F., Ferrara A., Sgaragli G. and Saponara S. (2007). Mechanisms of the antispasmodic
activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles. Eur. J.
Pharmacol., 561, 112-120.
40) Saponara S., Ferrara A., Gorelli B., Shah A., Kawase M., Sgaragli G. and Fusi F. (2007).
3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug
resistance inhibitor devoid of effect on Langendorff-perfused rat heart. Eur. J. Pharmacol.,
563, 160-163.
41) Fusi F., Ferrara A., Zalatnai A., Molnar J., Sgaragli G. and Saponara S. (2008). Vascular
activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance
reverting agents in cancer cells. Cancer Chemother. Pharmacol., 61, 443-451.
42) Fusi F., Ferrara A., Koorbanally C., Crouch N.R., Mulholland D.A. and Sgaragli G.
(2008). Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly
mediated by activation of soluble guanylyl cyclase. J. Pharm. Pharmacol., 60, 489-497.
43) Carosati E., Budriesi R., Ioan P., Ugenti M.P., Frosini M., Fusi F., Corda G., Cosimelli
B., Spinelli D., Chiarini A. and Cruciani G. (2008). Discovery of novel and cardioselective
diltiazem-like calcium channel blockers via virtual screening. J. Med. Chem., 51, 5552-5565.
44) Saponara S., Sgaragli G. and Fusi F. (2008). Quercetin antagonism of Bay K 8644 effects
on rat tail artery L-type Ca2+ channels. Eur. J. Pharmacol., 598, 75-80.
45) Bova S., Saponara S., Rampa A., Gobbi S., Cima L., Fusi F., Sgaragli G., Cavalli M., De
los Rios C., Striessnig J. and Bisi A. (2009). Anthracene based compounds as new L-type Ca2+
channel blockers: design, synthesis, and full biological profile. J. Med. Chem., 52, 1259-1262.
46) Budriesi R., Cosimelli B., Ioan P., Ugenti M.P., Carosati E., Frosini M., Fusi F.,
Saponara, S., Cruciani G., Novellino E., Spinelli D. and Chiarini A. (2009). L-Type calcium
channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one
derivatives. J. Med. Chem., 52, 2352-2362.
47) Carosati E., Budriesi R., Ioan P., Cruciani G., Fusi F., Frosini M., Saponara S., Gasparrini
F., Ciogli A., Villani C., Stephens P.J., Devlin F.J., Spinelli D. and Chiarini A. (2009).
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-
(2-thienyl)pyrrolidine, a new L-type calcium channel blocker. J. Med. Chem., 52, 6637-6648.
48) Fusi F., Cavalli M., Mulholland D., Crouch N.R., Coombes P., Dawson G., Bova S.,
Sgaragli G. and Saponara S. (2010). Cardamonin is a bifunctional vasodilator that inhibits
Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes. J. Pharmacol. Exp.
Ther., 332, 531-540.
49) Saponara S., Carosati E., Mugnai P., Sgaragli G. and Fusi F. (2011). The flavonoid
scaffold as a template for the design of modulators of the vascular Cav1.2 channels. Br. J.
Pharmacol., 164, 1684-1697.
50) Saponara S., Gorelli B., Tzankova V., Martelli C., Teodori·E., Sgaragli G. and Fusi F.
(2011). The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl
esters are devoid of vascular effects. Pharmacology, 88, 137-141. (I.F. 1.788)
51) Lacava C., Sgaragli G. and Fusi F. (2012). 3,5-Di-t-butylcatechol as a ryanodine receptor
agonist in rat intact skeletal muscle fibers. Drug Dev. Res., 73, 138-145.
52) Fusi F., Sgaragli G., Ha L.M., Cuong N.M. and Saponara S. (2012). Mechanism of
osthole inhibition of vascular Cav1.2 current. Eur. J. Pharmacol., 680, 22-27.
53) Lacava C., Michalek-Sauberer A., Kraft B., Sgaragli G., Sipos E., Höller C., Kress H.G.,
Fusi F. and Weigl L.G. (2012). 3,5-Di-t-butyl catechol is a potent human ryanodine receptor 1
activator, not suitable for the diagnosis of malignant hyperthermia susceptibility. Pharmacol.
Res., 66, 80-87.
54) Saponara S., Fusi F., Sgaragli G., Cavalli M., Hopkins B. and Bova S. (2012). Effects of
commonly used protein kinase inhibitors on vascular contraction and L-type Ca2+ current.
Biochem. Pharmacol., 84, 1055-1061.
55) Durante M., Sgaragli G., Biasutto L., Mattarei A. and Fusi F. (2013). Quercetin
mitochondriotropic derivatives antagonize nitrate tolerance and endothelial dysfunction of
isolated rat aorta rings. Planta Med., 79, 465-467.
56) Iozzi D., Schubert R., Kalenchuk V.U., Neri A., Sgaragli G., Fusi F. and Saponara S.
(2013). Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1
channels. Acta Physiol., in press.
CHAPTERS OF BOOKS
1) Sgaragli G.P., Fusi F. and Gorelli B. (1993). Methods of investigation of calcium
metabolism in smooth muscle cells. Training Course in Biochemical Pharmacology, Book of
the Course.
2) Benocci A., Frosini M., Fusi F., Gorelli B., Marazova K. and Sgaragli G.P. Current
methods for studying cell calcium (1997). Biochemical Pharmacological Techniques:
Theoretical & Experimental Aspects. Book of the Course.
3) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (1999). The patch-clamp technique:
development and uses to investigate Ca2+ currents. Gli Atti dell'Accademia delle Scienze di
Siena detta de' Fisiocritici, serie XV, tomo XVIII, 89-99.
4) Valoti M., Fusi F. and Sgaragli G.P. (2001). Phenolic antioxidants with calcium antagonist
properties: the need for novel, more specific food antioxidant. Fair Conference on Food
Antioxidants and Human Health. Ed. Sgaragli G.P. and Valoti M. pp. 57-67.
5) Fusi F., Saponara S., Pessina F., Gorelli B. and Sgaragli G.P. (2002). Effects of wine
polyphenols on vascular functions: an electro-mechanic investigation. Bioactive Compounds in
Plant Foods. Health Effects and Perspectives for the Food Industry. Ed. Amadò R., Abt B.,
Bravo L., Goñi I. And Saura-Calixto F. pp. 108-109.
6) Fusi F., Saponara S. and Sgaragli G.P. (2004). Effetto della quercetina e di alcuni
flavonoidi ad essa strutturalmente correlati, sulle correnti di Ca2+ di tipo L in cellule muscolari
lisce isolate dall’arteria principale della coda di ratto. Annali piante officinali, vol. 8, pp. 46-47.
ABSTRACTS
1) Fusi F., Valoti M., Gorelli B., Mantovani P. and Sgaragli G.P. (1992). Calcium antagonist
properties on rat ileum longitudinal muscle of 2-t-butyl-4-methoxyphenol (BHA). Pharmacol.
Res., 26 (suppl. 1), 322.
2) Zilletti L., Gentilini M.G., Franchi-Micheli S., Mugnai S., Ciuffi M., Valoti M., Moneti G.,
Fusi F. and Sgaragli G.P. (1992). Cyclooxygenase activity of haemoglobin: a comparative
study in different species. Pharmacol. Res., 26 (suppl. 1), 266.
3) Valoti M., Fusi F., Gorelli B., Palmi M. and Sgaragli G.P. (1993). Nifedipine-like
properties in normal and skinned ileum longitudinal muscle in rat and antiperoxidant activities
of some hindered phenols. Pharmacol. Res., 27 (suppl. 1), 69-70.
4) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Effects of 2-t-butyl-4-
methoxyphenol (BHA) on plasmalemma and intracellular Ca2+ transport in guinea pig gastric
fundus smooth muscle. Br. J. Pharmacol., 111, 251P.
5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Mugnai S., Valoti M. and
Sgaragli G.P. (1994). Metabolism of arachidonate catalysed by haemoglobin. Br. J.
Pharmacol., 111, 73P.
6) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M.,
Mugnai S. and Sgaragli G.P. (1994). Metabolism of arachidonic acid catalysed by
haemoglobin. Pharmacol. Res., 30 (4), 347.
7) Valoti M., Fusi F. and Sgaragli G.P. (1994). Free radicals inactivation by some antioxidant
hindered phenols in biological systems. Pharmacol. Res., 30 (4), 348-349.
8) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Effects of BHA on
plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus. Pharmacol. Res.,
30 (4), 349-350.
9) Gorelli B., Pessina F., Fusi F., Valoti M., Marazova K. and Sgaragli G.P. (1995). Calcium
antagonist properties of some hindered phenols on rat aortic rings. Pharmacol. Res., 31
(suppl.), 206.
10) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1995). The effect of allylamine on
the tension responses of cervine digital arteries in vitro to noradrenaline. Br. J. Pharmacol.,
116, 414P.
11) Frosini M., Fusi F., Palmi M., Bianchi L., Della Corte L. and Sgaragli G.P. (1996).
Taurine and calcium changes in rabbit CSF during exposure to high temperatures. Eur. J.
Neurosci., 9 (suppl.), 41.
12) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and
Tipton K.F. (1996). Effects of taurine on Ca2+ uptake and oxidative phosphorylation in
mitochondria. Eur. J. Neurosci., 9 (suppl.), 41.
13) Fusi F., Galgani F., Gorelli B., Valoti M. and Sgaragli G.P. (1997). Pleiotypic effects of
2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. Pharmacol. Res., 35
(suppl.), 77.
14) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1997). The effect of allylamine on
cervine vascular reactivity. Pharmacol. Res., 35 (suppl.), 225-226.
15) White R., Fusi F., Scarlett J.A. and Callingham B.A. (1997). Seasonal differences in the
reactivity of fallow deer digital artery. J. Auton. Pharmacol., 17, 217.
16) Fusi F., Tzankova V., Galgani F., Valoti M. and Sgaragli G.P. (1999). Effect of 3,5-di-t-
butyl-4-hydroxyanisole (DTBHA) on sarcoplasmic reticulum Ca2+-ATPase of rat skeletal
muscle. Pharmacol. Res., 39 (suppl.), 26.
17) Fusi F., Saponara S., Gorelli B., Alov P., Pessina F. and Sgaragli G.P. (1999).
Antispasmodic and antioxidant properties of some newly synthesised hindered phenols.
Pharmacol. Res., 39 (suppl.), 88.
18) Petkov G.V., Gagov H.S., Fusi F., Corsi M., Sgaragli G.P. and Boev K.K. (1999).
Calcium current in freshly isolated smooth muscle cells from rat tail artery. Pharmacol. Res.,
39 (suppl.), 54.
19) Petkov G.V., Gagov H.S., Fusi F., Sgaragli G.P. and Boev K.K. (1999). Effects of t-butyl
phenols on calcium current in smooth muscle cells. Pharmacol. Res., 39 (suppl.), 54.
20) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (2001). 2,5-Di-t-butyl-1,4-
benzohydroquinone (BHQ) inhibition of vascular L-type Ca2+ channel is mediated by
superoxide anion. Pharmacol. Res., 43 (suppl. A), 23.
21) Saponara S., Fusi F., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. (2001). Effects of
quercetin on vascular smooth muscle. Pharmacol. Res., 43 (suppl. A), 24.
22) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G. and
Fusi F. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7)
as a new MDR reverter devoid of vascular effects. J Chemother., 16 (suppl. 1).
23) Dragoni S., Valoti M., Fusi F., Saponara S. and Sgaragli G.P. (2006). Red wine and
health. Phytother. Res., 20, 327-328.
24) Schubert R., Saponara S., Fusi F., Iozzi D. (2007). The flavonoid quercetin relaxes
arteries by decreasing cytosolic and stored calcium. Acta Physiol., 189 (suppl. 653) O02-2.
25) Saponara S., Iozzi D., Fusi F., Sgaragli G. (2008). Plant polyphenols as modulators of
vascular ion channels. Acta Biochim. Pol., 55 (suppl. 1), 26-27.
26) Saponara S., Fusi F., Sgaragli G. (2008). Quercetin antagonism of Bay K 8644 effects on
rat tail artery L-type Ca2+ channels. Fundam. Clin. Pharmacol., 22 (suppl 2), 62.
27) Lacava C., Michalek-Sauberer A., Kraft B., Sgaragli G., Sipos E., Höller C., Kress H-G., Fusi
F., Weigl L.G. (2009). 3,5-Di-t-butyl catechol (DTCAT) as an activator of the human skeletal
muscle ryanodine receptor Ca2+ channel and its evaluation as a test substance for the
assessment of susceptibility to malignant hyperthermia. BMC Pharmacology, 9 (Suppl 2):A22.
28) Fusi F. (2011). Vascular ion channels as targets of wine polyphenols and their metabolites:
a possible explanation for their beneficial health effects. Eur. J. Nutr., 50, 491.
NATIONAL AND INTERNATIONAL MEETINGS
1) Valoti M., Fusi F., Zilletti L. and Sgaragli G.P. (1990). Peroxidation under anaerobic
conditions of arachidonic acid catalyzed by horseradish peroxidase in the presence of
hydroperoxide(s) of arachidonic acid. 7th International Conference on Prostaglandins and
Related Compounds. Florence, Italy, May 28-June 1.
2) Valoti M., Fusi F., Gorelli B., Palmi M. and Sgaragli G.P. (1991). Nifedipine-like
properties in normal and skinned ileum longitudinal muscle in rat and antiperoxidant activities
of some hindered phenols.VI Meeting of the Italian Society of Pharmacognosy. Rome, Italy, October 10-12.
3) Fusi F., Valoti M., Gorelli B., Mantovani P. and Sgaragli G.P. (1992). Calcium antagonist
properties on rat ileum longitudinal muscle of 2-t-butyl-4-methoxyphenol (BHA). XXVI
National Congress of the Italian Society of Pharmacology. Naples, Italy, September 29-
October 3.
4) Zilletti L., Gentilini M.G., Franchi-Micheli S., Mugnai S., Ciuffi M., Valoti M., Moneti G.,
Fusi F. and Sgaragli G.P. (1992). Cyclooxygenase activity of haemoglobin: a comparative
study in different species. XXVI National Congress of the Italian Society of Pharmacology.
Naples, Italy, September 29-October 3.
5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M. and
Sgaragli G.P. (1993). Haemoglobin-catalyzed metabolism of arachidonic acid. Riunione
monotematica nazionale of the Italian Society of Pharmacology. Siena, Italy, May 24.
6) Valoti M., Fusi F. and Sgaragli G.P. (1993). Free radical inactivation by some antioxidant
hindered phenols in biological systems. Riunione monotematica nazionale of the Italian Society
of Pharmacology. Siena, Italy, May 24.
7) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1993). Effects of BHA on
plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus smooth muscle.
Riunione monotematica nazionale of the Italian Society of Pharmacology. Siena, Italy, May 24.
8) Fusi F., Valoti M., Gorelli B., and Sgaragli G.P. (1993). Calcium antagonist and
antiperoxidant properties of hindered phenols.International meeting on: Pathophysiology of the
prooxidant/antioxidant balance. Molecular basis of medical application. Siena, Italy, June
24-26.
9) Fusi F., Valoti M., Gorelli B. and Sgaragli G.P. (1993). Calcium antagonist properties of
antioxidant hindered phenols. International symposium on antioxidant and disease prevention.
Stockholm, Sweden, June 30-July 3.
10) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1993). Effects of BHA on
plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus smooth muscle. V
Joint meeting between the British and Italian Societies of Pharmacology. Rome, Italy,
September 13-16.
11) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Mugnai S., Valoti M. and
Sgaragli G.P. (1993). Metabolism of arachidonate catalyzed by haemoglobin. V Joint meeting
between the British and Italian Societies of Pharmacology. Rome, Italy, September 13-16.
12) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Meccanismi
dell'azione spasmolitica del BHA sulla muscolatura liscia isolata dal fondo di stomaco di cavia.
Metodi Innovativi in Farmacologia, Gruppo Nazionale MURST 40%. Florence, Italy, May 30.
13) Fusi F. (1994). Derivati fenolici di origine naturale o sintetici con proprietà antiossidanti e
calcioantagonistiche come farmaci per la prevenzione dei danni tissutali da ischemia-
riperfusione susseguenti a infarto miocardico e ictus cerebrale. National Meeting of Ph.D.
Students in Pharmaceutical Sciences, Urbino, Italy, September 5-9.
14) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Spasmolysis by 2-t-
butyl-4-methoxyphenol in guinea pig gastric fundus smooth muscle contracted with
cyclopiazonic acid or tetraethylammonium. 6th International Symposium on Pharmacological
control of calcium and potassium homeostasis. Florence, Italy, October 4-6.
15) Giacobini E., Mori F., Lai C-C., and Fusi F. (1995). The effect of cholinesterase inhibitors
on the secretion of APPs from in rat brain cortex. In: Novel Therapeutic Approaches to AD
and other Memory Disorders Associated with Aging. Zurich, Switzerland.
16) Gorelli B., Pessina F., Fusi F., Valoti M., Marazowa K. and Sgaragli G.P. (1995).
Calcium antagonist properties of some hindered phenols on rat aortic rings. First European
Congress of Pharmacology. Milan, Italy, June 16-19.
17) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Dixon H. and Tipton K.F.
(1995). Effects of taurine and structurally-related analogues on Ca2+-uptake and respiration
rate in rat liver mitochondria. International Taurine Symposium '95. Taurine: basic and clinical
aspects. Osaka, Japan, June 27-July 1.
18) Sgaragli G.P., Frosini M., Palmi M., Fusi F., Sesti C., Della Corte L., Bianchi L., Galeffi
F., Bolam P., Dixon H. and Tipton K.F. (1995). Behavioural and cellular studies on some
compounds structurally-related to taurine. International Taurine Symposium '95. Taurine: basic
and clinical aspects. Osaka, Japan, June 27-July 1.
19) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1995). The effect of allylamine on
the tension responses of cervine digital arteries in vitro to noradrenaline. Autumn Meeting of
the British Pharmacological Society, University of Strathclyde, Glasgow, U.K., September 6-8.
20) Fusi F., Gorelli B., Pessina F., Valoti M., Marazova K. and Sgaragli G.P. (1995).
Proprietà calcio antagonisctiche di alcuni derivati fenolici su anelli di aorta di ratto. Metodi
Innovativi in Farmacologia, Gruppo Nazionale MURST 40%. Florence, Italy, October 20-21.
21) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1995). The effect of allylamine on
cervine vascular reactivity. Riunione congiunta monotematica delle Società Italiane di
Farmacologia e di Tossicologia sul metabolismo degli xenobiotici. Siena, Italy, November 3-4.
22) White R., Fusi F., Scarlett J.A. and Callingham B.A. (1996). Seasonal differences in the
reactivity of fallow deer digital artery. 9th Meeting on Adrenergic Mechanisms. Porto,
Portugal, September 22-25.
23) Frosini M., Fusi F., Palmi M., Bianchi L., Della Corte L. and Sgaragli G.P. (1996).
Taurine and calcium changes in rabbit CSF during exposure to high temperatures. 2nd Meeting
of European Neuroscience. Strasbourg, France, September 24-28.
24) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and
Tipton K.F. (1996). Effects of taurine on Ca2+ uptake and oxidative phosphorylation in
mitochondria. 2nd Meeting of European Neuroscience. Strasbourg, France, September 24-28.
25) Frosini M., Fusi F., Palmi M., Bianchi L., Della Corte L. and Sgaragli G.P. (1996).
Concentrazioni di taurina e Ca2+ nel CSF di coniglio durante esposizione ad alte temperature.
V Convegno Nazionale Giovani Cultori delle Neuroscienze. Pisa, Italy, December 12-14.
26) Fusi F., Galgani F., Gorelli B., Valoti M. and Sgaragli G.P. (1997). Pleiotypic effects of
2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. XXVIII National
Congress of the Italian Society of Pharmacology. Bari, Italy, April 30 - May 3.
27) Palmi M., Youmbi G., Fusi F., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and
Tipton K.F. (1997). Effect of taurine on calcium transport in rat liver mitochondria.
International Taurine Symposium '97. Neurochemistry, biochemistry and pharmacology.
Tucson, Arizona, USA, July 15-19.
28) Fusi F., Galgani F., Gorelli B., Valoti M. and Sgaragli G.P. (1998). Pleiotypic effects of
2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. First Virtual
Congress about Pharmacy (IVCP), University of Granada, Faculty of Pharmacy, Research
Group of Pharmaceutical Physical Chemistry (PAI), Computing and Network Communications
Services Centre, Spain, January-December 1998.
29) Fusi F., Corsi M., Pessina F., Galgani F. and Sgaragli G.P. (1998). Effects of 2,5-di-t-
butyl-1,4-benzohydroquinone (BHQ) on rat aorta endothelium-dependent relaxation. 6th joint
meeting of the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-16.
30) Tchuisseu Youmbi G., Palmi M., Fusi F., Frosini M., Sgaragli G.P., Della Corte L. and
Tipton K.F. (1998). Effects of taurine on Ca2+ transport in rat liver mitochondria. 6th joint
meeting of the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-16.
31) Pessina F., Marazova K., Gorelli B., Fusi F. and Sgaragli G.P. (1998). Antispasmodic
effects of some sterically hindered phenols on rat aorta ring preparations. 6th joint meeting of
the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-16.
32) Fusi F., Corsi M., Pessina F., Galgani F. and Sgaragli G.P. (1998). Effects of 2,5-di-t-
butyl-1,4-benzohydroquinone (BHQ) on rat aorta endothelium-dependent relaxation.
International symposium on cell injury from reperfusion and oxidative stress: new
pharmacological strategies for neuroprotection. Siena, Italy, November 9.
33) Tzankova V., Fusi F., Galgani F., Valoti M. and Sgaragli G.P. (1998). Effect of some
phenol derivatives on sarcoplasmic reticulum Ca2+-ATPase of rat skeletal muscle. International
symposium on cell injury from reperfusion and oxidative stress: new pharmacological
strategies for neuroprotection. Siena, Italy, November 9.
34) Fusi F., Tzankova V., Galgani F., Valoti M. and Sgaragli G.P. (1999). Effect of 3,5-di-t-
butyl-4-hydroxyanisole (DTBHA) on sarcoplasmic reticulum Ca2+-ATPase of rat skeletal
muscle. XXIX National Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.
35) Fusi F., Saponara S., Gorelli B., Alov P., Pessina F. and Sgaragli G.P. (1999).
Antispasmodic and antioxidant properties of some newly synthesised hindered phenols. XXIX
National Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.
36) Petkov G.V., Gagov H.S., Fusi F., Corsi M., Sgaragli G.P. and Boev K.K. (1999).
Calcium current in freshly isolated smooth muscle cells from rat tail artery. XXIX National
Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.
37) Petkov G.V., Gagov H.S., Fusi F., Sgaragli G.P. and Boev K.K. (1999). Effects of t-butyl
phenols on calcium current in smooth muscle cells. XXIX National Congress of the Italian
Society of Pharmacology. Florence, Italy, June 20-23.
38) Palmi M., Tchuisseu Youmbi G., Davey G., Meini A., Benocci A., Fusi F., Frosini M.,
Sgaragli G.P. and Tipton K.F. (1999). Taurine and mitochondria Ca2+ accumulation.
International Taurine Symposium 1999. Taurine and Excitable Tissues. Siena, Italy, August
4-8.
39) Sesti C., Frosini M., Palmi M., Valoti M., Fusi F., Bianchi L., Della Corte L. and Sgaragli
G.P. (1999). Changes in cerebrospinal fluid composition in conscious rabbit exposed to high
ambient temperatures: the possible role of taurine and GABA as cryogens. International
Taurine Symposium 1999. Taurine and Excitable Tissues. Siena, Italy, August 4-8.
40) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (1999). The patch-clamp technique:
development and uses to investigate Ca2+ currents. Accademia dei Fisiocritici, Siena, Italy,
November 24.
41) Fusi F., Saponara S., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effetto dei
polifenoli del vino sulla contrazione e sulla corrente del calcio nel muscolo vascolare.
Convegno "Vino e Salute: aspetti economici, sociali e medici". Siena, Italy, 11 December
2000.
42) Fusi F., Saponara S., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effects of wine
polyphenols on vascular functions: an electro-mechanic investigation. European Conference.
Bioactive Compounds in Plant Foods. Health effects and perspectives for the food industry.
Tenerife, Canary Islands, Spain, 26-28 April 2001.
43) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. 2,5-Di-t-butyl-1,4-benzohydroquinone
(BHQ) inhibition of vascular L-type Ca2+ channel is mediated by superoxide anion. XXX
National Congress of the Italian Pharmacological Society. Genoa, Italy, May 30-June 2, 2001.
44) Saponara S., Fusi F., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effects of
quercetin on vascular smooth muscle. XXX National Congress of the Italian Pharmacological
Society. Genoa, Italy, May 30-June 2, 2001.
45) Saponara S., Fusi F., Pessina F., Gorelli B., and Sgaragli G. Effects of wine polyphenols
on vascular smooth muscle. Dietary phytochemicals and human health. Salamanca, Spain, April
18-20, 2002.
46) Valoti M., Ponticelli F., Fontani M., Fusi F., Saponara S., Pessina F. and Sgaragli G.P.
Effects of novel antioxidants, phenol derivatives on human erythrocytes under oxidative stress
promoted by AAPH. XIII National Congress of the Italian Toxicological Society. Urbino,
Italy, January 22-25, 2003.
47) Saponara S., Frosini M., Sgaragli G.P. and Fusi F. Interactions between two Ca2+ channel
activators, quercetin and BAY K 8644, in vascular smooth muscle. XXXI Congresso
Nazionale della Società Italiana di Farmacologia. Trieste, Italy, June 26-29, 2003.
48) Fusi F., Saponara S., Pessina F., Gorelli B. and Sgaragli G.P. Flavonoids: a new class of
vascular smooth muscle L-type Ca2+ channel modulators. XXXI Congresso Nazionale della
Società Italiana di Farmacologia. Trieste, Italy, June 26-29, 2003.
49) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G. and
Fusi F. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7)
as a new MDR reverter devoid of vascular effects. 1st ISC International Conference on Cancer
Therapeutics, Molecular Targets, Pharmacology and Clinical Applications. Florence, Italy,
February 19-21, 2004.
50) Fusi F., Saponara S. and Sgaragli G.P. (2004). Effects of quercetin and some flavonoids,
structurally related to it, on L-type Ca2+ current of rat tail main artery myocytes. "Flavonoidi
Chimica, Farmacognosia, Farmacologia ed Impiego Terapeutico". Naples, Italy, April 3, 2004.
51) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Fusi F. and
Sgaragli G. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine
(DP7) as a new MDR reverter devoid of effects on vascular smooth muscle contractility.
Giovanni Armenise-Harvard Foundation 8th Annual Symposium on Cancer Biology and
Genomics and Post-Genomics. Siena, Italy, May 21-23, 2004.
52) Fusi F., Saponara S. and Sgaragli G.P. Effects of quercetin and other structurally related
flavonoids on L-type Ca2+ current of rat tail main artery myocytes. European Workshop on
Cellular responses to bioactive plant compounds - implications for human health. Budapest,
Hungary, September 30-October 2, 2004.
53) Fusi F., Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K. and
Sgaragli G. 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a
new multidrug resistance reverting agent devoid of effects on vascular smooth muscle
contractility. Pharmacological strategies to overcome multidrug resistance in cancer
chemotherapy. Siena, Italy, November 22, 2004.
54) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G. and
Fusi F. 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new
multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility.
International Symposium on Reversal of Multidrug Resistance in Cancer Cells. Szeged,
Hungary, December 13, 2004.
55) Saponara S., Fusi F., Iozzi D., Lorusso F., Sgaragli G. Mechanism of myricetin
stimulation of vascular L-type Ca2+ current. XXXII Congresso Nazionale della Società Italiana
di Farmacologia. Naples, Italy, June 1-4, 2005.
56) Fusi F., Gelli M., D’Elia P., Saponara S., Molnar J. and Sgaragli G. Vascular effects of
new silicon compounds active as resistance modifier against multidrug-resistant cancer cells.
Pharmacological strategies to overcome multidrug resistance in cancer chemotherapy. II
Annual Symposium. Siena, Italy, November 22, 2005.
57) Ioan P., Budriesi R., Ugenti M.P., Chiarini A., Carosati E., Cruciani G., Spinelli D.,
Cosimelli B., Novellino E., Fusi F., Frosini M., Gasparrini F., Stephen P.J. Un Approccio
Multidisciplinare per lo Studio di Nuovi Modulatori dei Canali del Ca2+ di tipo-L. Med. Chem.
Division of the XXII Congresso Nazionale della Società Chimica Italiana. Florence, Italy,
September 10-15, 2006.
58) Fusi F., Saponara S., Testai L., Iozzi D., Martinotti E., Martelli A., Chericoni S., Sgaragli
G., Calderone V. (+/-)-Naringenin as KCa 1.1 channels opener in vascular smooth muscle cells.
Molecular and physiological effects of bioactive food compounds. Wien, Austria, October
11-14, 2006.
59) Sgaragli G., Fusi F., Saponara S. Functional interactions between two L-type Ca2+ channel
activators, quercetin and Bay K 8644, in rat tail artery myocytes. Molecular and physiological
effects of bioactive food compounds. Wien, Austria, October 11-14 2006.
60) Alderighi D., Gori M., Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi
F., Kawase M., Shah A., Motohashi N., Molnar J., Sgaragli G. Inhibition of P-gp/ATPase
activity of rat small intestine membrane vesicles by the novel, dihydropyridine MDR reverter
DP7. Pharmacological strategies to overcome multidrug resistance in cancer chemotherapy. III
Annual Symposium. Certosa di Pontignano, Siena, Italy, November 14, 2006.
61) Lacava C., Sipos E., Höller C., Kress H.G., Sgaragli G., Fusi F., Weigl L. Use of 3,5 di-t-
butylcatechol (DTCAT) in the diagnosis of malignant hyperthermia (MH). European Malignant
Hyperthermia Group 2007 Meeting, Certosa di Pontignano, Siena, Italy, May 20-23, 2007.
62) Alderighi D., Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi F., Shah
A., Kawase M., Motohashi N., Molnar J., Sgaragli G. Inhibition of P-gp/ATPase activity of rat
small intestine membrane vesicles by the novel, dihydropyridine MDR reverter DP7. XXXIII
Congresso Nazionale della Società Italiana di Farmacologia. Cagliari, Italy, June 6-9, 2007.
63) Ferrara A., Fusi F., Koorbanally C., Crouch N.R., Mulholland D.A., Sgaragli G. Vascular
activity of isolates from the hyacinthaceae of South Africa. XXXIII Congresso Nazionale della
Società Italiana di Farmacologia. Cagliari, Italy, June 6-9, 2007.
64) D’Elia P., Dragoni S., Valoti M., De Matteis F., Saponara S., Fusi F., Sgaragli G.
Inhibition studies of DP7, a novel MDR reverter,on CYP-dependent activities in human and rat
liver microsomes. Pharmacological strategies to overcome multidrug resistance in cancer
chemotherapy. IV Annual Symposium. Certosa di Pontignano, Siena, Italy, November 19-20,
2007.
65) Saponara S., Fusi F., Ricci L., Frosini M., Dragoni S., Valoti M., Valeri A., Pessina F.,
Sgaragli G. I polifenoli di origine naturale e la salute umana: effetti su rilevanti bersagli
farmacologici. Congresso Nazionale: Farmaci Naturali. Attualità e Prospettive Future.
Benevento, Italy, March 27-29, 2009.
66) Fusi F. (2011). Vascular ion channels as targets of wine polyphenols and their metabolites:
a possible explanation for their beneficial health effects. Seminario Scientifico sul bere
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Source: http://www.dsv.unisi.it/sites/st15/files/allegatiparagrafo/17-05-2013/fabiofusi.pdf