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DBSA MADISON CHAPTER
Volume 5, Issue 8
August 2010

Chapter News
Typical Anti-Psychotics – Part 2
In the June newsletter, typical anti-psychotic Our next meetins will take place on
August 12 and 26, from 6:30pm until
drugs were discussed in detail. As a recap, these drugs were the first anti-psychotics to 8:30pm, in the Magnolia A room.
be developed, and they typically have more We hope to see you there!!!
negative side effects than their cousins, The typical anti-psychotic drugs approved to treat bipolar disorder are Haldol, Thorazine, Navane, Orap, Prolixin, Stelazine, Triliphon, and Trilaton. Haldol, Thorazine, and Navane were covered in our previous issue. This newsletter will cover Orap, Prolixin, and Trilifon. Stelazine, Thioridazine, and Trilaton I N S I D E T H I S I S S U E
1 Chapter News
2 Typical Anti-Psychotics – Part 2
3- Typical Anti-Psychotics (continued)
6
DBSA MADISON CHAPTER 1
Orap is an antipsychotic agent. It works by  a history of liver or kidney problems, blocking the action of dopamine, a naturally  you are treating simple tics or tics  you are taking astemizole, cisapride, Orap. Tell your doctor or pharmacist if you have any medical conditions, especially if any  if you are taking any prescription or  if you have breast cancer, a blockage DBSA MADISON CHAPTER 2
 Involuntary and uncontrollable movements may develop in patients taking Orap . Occurrence is highest among the elderly, especially women. The risk of developing these involuntary movements and the likelihood they will become permanent are increased with long-term use and with high doses. However it is possible to develop these symptoms after short-term treatment at low doses. Contact your health care provider at once if any of the following occur: involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs.  LAB TESTS, including heart function tests and blood potassium and magnesium levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.  Use Orap with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.  PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Orap , discuss with your doctor the benefits and risks of using Orap during pregnancy. It is unknown if Orap is excreted in breast milk. Do not breast-feed while taking Orap . If you suddenly stop taking Orap, you may experience WITHDRAWAL symptoms, including involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements) or involuntary movements of the arms and legs. All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased sexual function; fever; involuntary movements of the tongue, mouth, face, or jaw; irregular heartbeat; muscle stiffness or spasm; trouble sleeping; unusual body movements; vision changes. Fluphenazine is an anti-psychotic medication in a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. What is the most important information I should know about fluphenazine? Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Fluphenazine is not for use in psychotic conditions related to dementia. Fluphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Do not use fluphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to fluphenazine or other phenothiazines. DBSA MADISON CHAPTER 3
Before you take fluphenazine, tell your doctor if you have heart disease or high blood pressure, a history of seizures, Parkinson's disease, liver or kidney disease, severe asthma or breathing problem, past or present breast cancer, adrenal gland tumor, enlarged prostate, urination problems, glaucoma, low levels of calcium in your blood, or if you have ever had a serious side effect while using fluphenazine or similar medicines. What should I avoid while taking fluphenazine? Fluphenazine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. It can increase some of the side effects of fluphenazine. Avoid exposure to sunlight or tanning beds. Fluphenazine can make yourmore sensitive to sunlight, and a sunburn may result. Wear sunscreen (SPF 15 or higher) and protective clothing if you must be outdoors. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using fluphenazine and call your doctor at once if you have a serious side effect such as:  twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;  tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or  feeling restless, jittery, or agitated;  feeling like you might pass out;  seizure (convulsions);  decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;  pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;  nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);  high fever, stiff muscles, confusionfast or uneven heartbeats, rapid breathing;  urinating less than usual or not at all;  joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or  slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).  dizziness, drowsiness, anxiety;  breast swelling or discharge;  sleep problems (insomnia), strange dreams;  blurred vision, headache;  changes in your menstrual periods;  impotence, trouble having an orgasm;  weight gain, swelling in your hands or feet;  dry mouth or a stuffy nose;  constipation; or  mild itching or skin rash. DBSA MADISON CHAPTER 4
Perphenazine is an anti-psychotic medication in a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. What is the most important information I should know about Trilafon (perphenazine)? Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Perphenazine is not for use in psychotic conditions related to dementia. Perphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Do not use perphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to perphenazine or other phenothiazines. Before you take perphenazine, tell your doctor if you have severe depression, heart disease or high blood pressure, liver or kidney disease, severe asthma or breathing problems, history of seizures, Parkinson's disease, past or present breast cancer, adrenal gland tumor, enlarged prostate or urination problems, glaucoma, low levels of calcium in your blood, or if you have ever had serious side effects while using chlorpromazine or similar medicines. What should I avoid while taking Trilafon (perphenazine)? Perphenazine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. It can increase some of the side effects of perphenazine. Avoid exposure to sunlight or tanning beds. Perphenazine can make yourmore sensitive to sunlight, and a sunburn may result. Wear sunscreen (SPF 15 or higher) and protective clothing if you must be outdoors. Trilafon (perphenazine) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using perphenazine and call your doctor at once if you have a serious side effect such as:  twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;  tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;  feeling restless, jittery, or agitated;  confusion, unusual thoughts or behavior;  feeling like you might pass out;  seizure (convulsions);  decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;  nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);  high fever, stiff muscles, confusion, fast or uneven heartbeats, rapid breathing;  pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;  urinating less than usual or not at all;  joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or  slow heart rate, weak pulse, fainting, slow breathing (breathing may stop). DBSA MADISON CHAPTER 5
 dizziness, drowsiness, anxiety;  blurred vision, headache;  sleep problems (insomnia), strange dreams;  constipation;  dry mouth or stuffy nose;  breast swelling or discharge;  changes in your menstrual periods;  weight gain, swelling in your hands or feet;  impotence, trouble having an orgasm; or  mild itching or skin rash. DBSA MADISON CHAPTER 6

Source: http://dbsamadison.org/Newsletters/2010August.pdf