Present address UPCM CR7 Université Pierre et Marie Curie, INSERM U1135, CNRS ERL 8255, Pitié-Salpêtrière, 91 Bd de l’Hôpital, 75013 Paris, France. Tel: +33 6 85 31 06 49 e-ma Positions since 2000 2000-2004
Senior Researcher, then DR2 CNRS (URA 2581), in the laboratory of Dr.
Pierre Druilhe, Unité de Parasitologie Biomédicale, Institut Pasteur, 25 Rue Du Dr. Roux, 75724 Paris Cedex 15, France.
2004-2008
Head of USM0307 (IFR101), Unité de Parasitologie Comparée et Modèles
Expérimentaux, Muséum National d'Histoire, CP52, 61 Rue Buffon, 75231 Paris Cedex 5, France.
2008-2013
Senior Scientist at the UPMC/INSERM UMR S 945 (previously UMR S 911)
“Immuno-Biologie Cellulaire et Moléculaire des Infections Parasitaires”, Université Pierre et Marie Curie (Paris VI), Centre Hospitalo-Universitaire Pitié-Salpêtrière, 91 Boulevard de l’Hôpital-75643 Paris Cedex 13, France.
(2008-2011)Visiting Senior Research Fellow, Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, National University of Singapore, Singapore. (2008-2011) Visiting Senior Researcher, Laboratory of Malaria Immunobiology, Singapore Immunology Network, A*STAR - Biopolis, Singapore. 2014-Co-Head of the CIMI’s Team 6 “Malaria: identification and pre-clinical validation of novel
therapeutics”UPCM CR7 Université Pierre et Marie Curie, INSERM U1135, CNRS ERL 8255, Pitié-Salpêtrière, 91 Bd de l’Hôpital, 75013 Paris, France.
Selected Publications (past 10 years) H factor: 41
1. Belnoue E, Costa FTM, Frankenberg T, Vigário AM, Voza T, Leroy N, Rodrigues MM, Landau I,
Snounou G, & Rénia L (2004) Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment.Journal of Immunology172, 2487- 295.
2. Imwong M, Pukrittayakamee S, Grüner AC, Rénia L, Letourneur F, Looareesuwan S, White NJ, &
Snounou G (2005) Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1.Malaria Journal4, 20.
3. Grüner AC, Hez-Deroubaix S, Snounou G, Hall N, Bouchier C, Letourneur F, Landau I, & Druilhe
P (2005) Insights into the P. y. yoelii hepatic stage transcriptome reveal complex transcriptional patterns.Molecular and Biochemical Parasitology142, 184-192.
4. Voza T, Vigário AM, Belnoue E, Grüner AC, Deschemin J-C, Kayibanda M, Delmas F, Janse CJ,
Franke-Fayard B, Waters AP, Landau I, Snounou G, & Rénia L (2005) Species-specific inhibition of cerebral malaria in mice coinfected with Plasmodium spp.Infection and Immunity73, 4777- 4786.
5. Carraz M, Jossang, A, Franetich, JF, Siau A, Ciceron L. Hannoun L, Sauerwein R, Frappier F,
Rasoanaivo P, Snounou G & Mazier D (2006) A plant-derived morphinan as a novel lead compound active against malaria liver stages. PLoS Medicine 3, e513.
6. Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JR, Nandy A, Guthmann JP,
Nosten F, Carlton J, Looareesuwan S, Nair S, Sudimack D, Day NP, Anderson TJ & White NJ
(2007) Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. Journal of Infectious Diseases 7, 927-933.
7. Yamauchi LM, Coppi A, Snounou G & Sinnis P (2007) Plasmodium sporozoites trickle out of the
injection site. Cellular Microbiology 9, 1215-1222.
8. Grüner AC, Mauduit M, Tewari R, Romero JF, Depinay N, Kayibanda M, Lallemand E, Chavatte
JC, Crisanti A, Sinnis P, Mazier D, Corradin G, Snounou G & Rénia L (2007) Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS ONE 2, e1371.
9. Roestenberg M, McCall M, Hopman J, Wiersma J, Luty AJF, Van Gemert G-J, Van de Vegte-
Bolmer M, Van Schaijk B, Teelen K, Arens T, Spaarman L, De Mast Q, Roeffen W, Snounou G, Rénia L, Van der Ven A, Hermsen CC & Sauerwein R (2009) Protection against a malaria challenge by sporozoite inoculation. New England Journal of Medicine361, 468-477.
10. Mazier D, Rénia L & Snounou G (2009) A pre-emptive strike against malaria's stealthy hepatic
forms. Nature Reviews. Drug Discovery8, 854-64.
11. Krief S, Escalante AA, Pacheco MA, Mugisha L, André C, Halbwax M, Fischer A, Krief J-M,
Kasenene JM, Crandfield M, Cornejo OE, Chavatte J-M, Lin C, Letourneur F, Grüner AC, McCutchan TF, Rénia L & Snounou G (2010) On the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from bonobos. PLoS Pathogens6, e1000765.
12. Sutherland CJ, Tanomsing N, Nolder D, Oguike M, Jennison C, Pukrittayakamee S, Dolecek C,
Tran Tinh Hien, Do Rosário VE, Arez AP, Pinto J, Michon P, Escalante AA, Nosten F, Burke M, Lee R, Blaze M, Otto TD, Barnwell JW, Pain A, Williams J, White NJ, Day NPJ, Snounou G, Lockhart PJ, Chiodini PL, Imwong M & Polley SD (2010) Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. Journal of Infectious Diseases 201, 1544-1550.
13. Carvalho BO, Lopes SCP, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite
JA, Rodrigues MM, Soares IS, Oliveira TR, Wunderlich G, Lacerda MVG, Del Portillo HA, Araújo MOG, Russell B, Suwanarusk R, Snounou G, Rénia L & Costa FTM (2010) On the cytoadhesion of Plasmodium vivax-infected erythrocytes. Journal of Infectious Diseases202, 638- 647.
14. Dembélé L, Gego A, Zeeman A-M, Franetich J-F, Silvie O, Rametti A, Le Grand R, Dereuddre-
Bosquet N, Sauerwein R, van Gemert G-J, Vaillant J-C, Thomas AW, Snounou G, Kocken CHM & Mazier D (2011) Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery. PLoS ONE6, e18162.
15. Russell B, Suwanarusk R, Borlon C, Costa FTM, Chu CS, Rijken MJ, Sriprawat K, Warter L, Koh
EGL, Malleret B, Colin Y, Bertrand O, Adams JH, D'Alessandro U, Snounou G, Nosten F & Rénia L (2011) A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. Blood118, e74-e81.
16. Obeid M, Franetich J-F, Lorthiois A, Gego A, Grüner AC, Tefit M, Boucheix C, Snounou G &
Mazier D (2013) Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria. EMBO Molecular Medicine5, 250-263.
17. Snounou G & Pérignon J-L (2013) Malariotherapy - Insanity at the service of malariology. Advances in Parasitology81, 223-255.
18. Dembélé L, Franetich JF, Lorthiois A, Gego A, Zeeman AM, Kocken CH, Le Grand R, Dereuddre-
Bosquet N, Sauerwein R, van Gemert GJ, Vaillant JC, Hannoun L, Fuchter MJ, Malmquist NA, Scherf A, Snounou G, Mazier D. (2014) Persistence and activation of malaria hypnozoites in long- term primary hepatocyte cultures. Nature Medicine 2014, Feb 9.
General Summary This guide instructs the methods, reaction principles and points for attention for the use of Uritest Reagent Strips. Uritest Reagent Strips are made for urinalysis of both qualitative and semi-quantitative, which are in vitro reagent for diagnostics. The strips are for professional use only. Reagent Strips are the primary testing product for the diseases of abnormal kidney
D: SGA: birth weight < 20th percentile for gestational age or < 2.5 kg. LGA: birth weight > 90th percentile for gestational age or > 4 kg. A: SGA: may be familial, constitutional, or due to IUGR. IUGR is defined as either symmetrical or asymmetrical:Asymmetrical IUGR: relative sparing of head circumference in relation toweight and length:. Due to impaired uteroplacental function 28
Present address UPCM CR7 Université Pierre et Marie Curie, INSERM U1135, CNRS ERL 8255,