Ark Pharm, Inc. MATERIAL SAFETY DATA SHEET 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION MSDS Name: Tretinoin CAS Number: 302-79-4 Catalog Numbers: AK-73126 Company Identification: 2. COMPOSITION, INFORMATION ON INGREDIENTS Molecular Formula: Molecular Weight: Component Concentration CAS Number 3. HAZARDS IDENTIFICATIONEMERGENCY OVERVIEW 3.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Specific target organ toxicity - single exposure (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Harmful if swallowed. Irritating to eyes, respiratory system and skin.
3.2 Label elements Labelling according Regulation (EC) No 1272/2008 [CLP]
IF IN EYES: Rinse cautiously with water for several
minutes. Remove contact lenses, if present and easy to do. Ark Pharm, Inc. According to European Directive 67/548/EEC as amended
Irritating to eyes, respiratory system and skin.
immediately with plenty of water and seek medical advice.
Wear suitable protective clothing and gloves. 3.3 Other hazards 4. FIRST AID MEASURES Eyes: Flush eyes with plenty of water occasionally lifting the upper and lower lids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is 5. FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide or chemical foam. 6. ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment. Spills/Leaks: Vacuum or sweep up material and place into suitable disposalcontainer. Avoid generating dusty conditions. 7. HANDLING AND STORAGE Handling: Avoid breathing dust, vapor, mist or gas. Avoid contact with eyes, skin. Storage: Storage temperature: 2 - 4 °C and Keep container tightly closed in a dry and well-ventilated place. 8. EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and safety
shower. Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear chemical safety goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Wear appropriate respirators where necessary. 9. PHYSICAL AND CHEMICAL PROPERTIES Ark Pharm, Inc. 10. STABILITY AND REACTIVITY Chemical Stability: This product is relatively unstable under normal temperature. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous combustion or Decomposition products: Carbon monoxide, carbon dioxide. 11. TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Acute toxicity Skin corrosion/irritation Serious eye damage/eye irritation Respiratory or skin sensitization Germ cell mutagenicity Carcinogenicity
No component of this product present at levels greater than or equal to 0.1% is identified as probable,
possible or confirmed human carcinogen by IARC. Reproductive toxicity Specific target organ toxicity - single exposure Specific target organ toxicity - repeated exposure Aspiration hazard Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
12. ECOLOGICAL INFORMATION 12.1 Toxicity 12.2 Persistence and degradability 12.3 Bioaccumulative potential 12.4 Mobility in soil 12.5 Results of PBT and vPvB assessment 12.6 Other adverse effects Ark Pharm, Inc. 13. DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal
service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator
equipped with an afterburner and scrubber.
Contaminated packaging 14. TRANSPORT INFORMATION 14.1 UN number 14.2 UN proper shipping name 14.3 Transport hazard class(es) 14.4 Packaging group 14.5 Environmental hazards 14.6 Special precautions for user 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture: Chemical Safety Assessment: No data available. 16. ADDITIONAL INFORMATION
The above information pertains to this product as currently formulated, and is based on the information available at this time.
Addition of reducers or other additives to this product may substantially alter the composition and hazards of the product. Since
conditions of use are outside our control, we make no warranties, express or implied, and assume no liability in connection
BASIC FIRE SAFETY Self-Study Guide OBJECTIVES OF THE BASIC FIRE SAFETY PROGRAM Upon completion of this self-study guide, you should be able to identify classes of fires, types of fire extinguishers and your role in the Basic Fire Safety Program. Successful completion of this program can be accomplished by completing the examination on the last page of this self-study guide with a s
Topical Tacrolimus and the 308-nm Excimer Laser A Synergistic Combination for the Treatment of Vitiligo Thierry Passeron, MD; Nima Ostovari, MD; Wassim Zakaria, MD; Eric Fontas, MD;Jean-Claude Larrouy, MD; Jean-Philippe Lacour, MD; Jean-Paul Ortonne, MD Objective: To compare the efficacy of combined tacro- Results: Forty-three lesions were treated (23 in group limus and 308-nm exci
Ark Pharm, Inc.
Ark Pharm, Inc.
Ark Pharm, Inc.
Ark Pharm, Inc.