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Microsoft word - rx consultant patent expiration table 010711.doc

Estimated dates are subject to change due to patent litigation, additional patents, exclusivities…

Estimated Dates of Possible First Time Generic/ Rx-to-OTC Market Entry
2009 US Retail Sales:
Brand Name
Generic name
(in millions)^

Information current as of January 2011. Estimated dates are subject to change due to patent
litigation, additional patents, exclusivities…

Medco is a registered trademark of Medco Health Solutions, Inc.
2011 Medco Health Solutions, Inc. All rights reserved.
Estimated dates are subject to change due to patent litigation, additional patents, exclusivities…

2009 US Retail Sales:
Brand Name
Generic name
(in millions)^

Information current as of January 2011. Estimated dates are subject to change due to patent
litigation, additional patents, exclusivities…

Medco is a registered trademark of Medco Health Solutions, Inc.
2011 Medco Health Solutions, Inc. All rights reserved.
Estimated dates are subject to change due to patent litigation, additional patents, exclusivities…

2009 US Retail Sales:
Brand Name
Generic name
(in millions)^

Information current as of January 2011. Estimated dates are subject to change due to patent
litigation, additional patents, exclusivities…

Medco is a registered trademark of Medco Health Solutions, Inc.
2011 Medco Health Solutions, Inc. All rights reserved.
Estimated dates are subject to change due to patent litigation, additional patents, exclusivities…

2009 US Retail Sales:
Brand Name
Generic name
(in millions)^

Information current as of January 2011. Estimated dates are subject to change due to patent
litigation, additional patents, exclusivities…

Medco is a registered trademark of Medco Health Solutions, Inc.
2011 Medco Health Solutions, Inc. All rights reserved.
Estimated dates are subject to change due to patent litigation, additional patents, exclusivities…

2009 US Retail Sales:
Brand Name
Generic name
(in millions)^

Information current as of January 2011. Estimated dates are subject to change due to patent
litigation, additional patents, exclusivities…

Medco is a registered trademark of Medco Health Solutions, Inc.
2011 Medco Health Solutions, Inc. All rights reserved.
Estimated dates are subject to change due to patent litigation, additional patents, exclusivities…

2009 US Retail Sales:
Brand Name
Generic name
(in millions)^

Information current as of January 2011. Estimated dates are subject to change due to patent
litigation, additional patents, exclusivities…

Medco is a registered trademark of Medco Health Solutions, Inc.
2011 Medco Health Solutions, Inc. All rights reserved.
Estimated dates are subject to change due to patent litigation, additional patents, exclusivities…

2009 US Retail Sales:
Brand Name
Generic name
(in millions)^
^ Dollar amount reflects combined sales of all strengths and formulations of the product, unless otherwise indicated; source IMS Health 1 Several companies have announced the settlement of patent litigation relating to Desloratadine Tablets, 5 mg (Clarinex). Pursuant to these settlements, the generic manufacturers will have the right to market Desloratadine Tablets, 5 mg, in the U.S. on July 1, 2012, or earlier in certain circumstances. Clarinex and Clarinex D will likely be switched to OTC availability prior to generic availability. 2 Lexapro’s '712 patent was originally slated to expire in December 2009, which included an additional six months of pediatric exclusivity. The U.S. Patent & Trademark Office granted the patent an 828-day extension in March 2006. Therefore, the estimated date for generic availability changed to March 2012. A recent patent litigation decision has also sided with Forest, upholding the validity of a key patent on Lexapro and keeping generics off the market until patent expiration in 2012. 3 Generic Plavix was approved 1/20/06 with paragraph IV certification giving Apotex 180-day exclusivity. Apotex launched their generic “at risk” on August 8, 2006. A preliminary injunction was granted on August 31, ordering Apotex to halt its sales of generic Plavix. The judge did not require Apotex to recall clopidogrel that had already
Information current as of January 2011. Estimated dates are subject to change due to patent
litigation, additional patents, exclusivities…

Medco is a registered trademark of Medco Health Solutions, Inc.
2011 Medco Health Solutions, Inc. All rights reserved.
Estimated dates are subject to change due to patent litigation, additional patents, exclusivities…
been distributed. Bristol-Myers Squibb/Sanofi’s patent infringement trial against Apotex
began January 22, 2007.
4 Mylan launched their first-time generic for Xopenex inhalation solution 0.25% with 180
day exclusivity in September 2009. In April 2008, Breath Limited received FDA
approval for their generic Xopenex inhalation solution 0.021%, .0042%, and 0.0103%.
Sepracor settled a patent dispute with them which will allow Breath to market generic
versions of the drug beginning August 2012 with a 180-day exclusive license. In March
2009, Sepracor entered into a Settlement and License Agreement with Teva and Barr.
The agreement permits Barr and Teva to launch generic versions of Xopenex inhalation
solution dosages under terms of a non-exclusive license commencing on February 17,
2013.
5 Diovan received pediatric exclusivity, extending the drug's patent protection in the US
until September 2012.
6 Patent litigation between Teva and Merck is ongoing. The U.S. Court of Appeals for the
Federal Circuit court is reviewing an appeal by Merck. If the Appeals court agrees that
Merck’s patent is unenforceable, Teva may launch their generic at any time.
7 Warner Chilcott sued Watson for patent infringement in 2006. A settlement was
reached in January 2009. Warner Chilcott sued Lupin for patent infringement in
September 2009.
8 In October 2007, Teva received FDA approval of its ANDA for Actonel 5 mg, 30 mg,
and 35 mg tablets but did not launch due to ongoing patent litigation. In February 2008,
the U.S. District Court for the District of Delaware found Procter & Gamble’s U.S. Patent
No. 5,538,122 covering Actonel to be valid. Teva intends to appeal this decision.
9 Boehringer Ingelheim sued Teva/Barr for patent infringement in July 2007. The
companies announced a settlement agreement in August 2008.
Note: Pulmicort dry powder inhalation and Advair have been removed from the table.
These both contain inhaled corticosteroids, and the FDA has not determined a standard
for bioequivalence for inhaled corticosteroids in multi-dose inhalers (MDIs) or dry
powder inhalers (DPIs). Therefore, generic availability may be significantly delayed. At
this time, there is no estimated date of generic approval.

Information current as of January 2011. Estimated dates are subject to change due to patent
litigation, additional patents, exclusivities…

Medco is a registered trademark of Medco Health Solutions, Inc.
2011 Medco Health Solutions, Inc. All rights reserved.

Source: http://media.arkansasonline.com/news/documents/2011/08/06/anticipatedfirsttime_generics.pdf

lab.univet.es

The WALTHAM International Nutritional Sciences SymposiaBovine Colostrum Increases Proliferation of Canine Skin Fibroblasts1,2Celina Torre,*3 Isabelle Jeusette,* Montserrat Serra,y Pilar Brazis,y and Anna Puigdemontz* R&D Department, Affinity Petcare, Barcelona, Spain; yUnivet, Cerdanyola, Spain by Univet, Barcelona,Spain; and zDepartment de Farmacologia, Universitat Auto`noma de Barcelon

Microsoft word - amerighi.doc

“Ascolta la voce del mio grido o mio re e mio Dio perché ti prego, Signore. Al mattino ascolta la mia voce fin dal mattino t’invoco e sto in attesa.” Questa notte non ho chiuso occhio. Il picchiettio fastidioso e gelido e irregolare di un ramo sulla mia finestra mi ha costretto ad uno strano stato di allerta, come quello di una sentinella che se ne sta lì ad aspettare qualcosa che forse

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