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Microsoft word - p450 chart.doc

This is an illustrative guide to the cytochrome P450 contribution to drug interactions likely for medication pairs that are
substrates, inhibitors or inducers of the same enzyme. More than one-half of patients also carry genetic variations in
CYP 1A2, 2C9, 2C19, and 2D6 genes that can dramatically alter patient drug exposures, and for which DNA testing can
be ordered. The GeneMedRx drug interaction software provides a more complete and automated tool for comprehensive
medication management, with optional input of genetic variations, OTCs, foods, herbals, and other relevant patient
factors to produce drug interaction reports based on the cumulative effect of all known drug metabolism variables. Obtain
a fully functional 30-day free trial at www.GeneMedRx.com or call 1-800-837-8362.
P450 DRUG-INTERACTIONS SUBSTRATES TABLE (compiled by Jessica Oesterheld, M.D.)
Substrates (primary enzyme for metabolism) italics = brand name {brackets} = minor or less potent bold = potent (p) = pro-drug > = entire class or group
Psychotropics:
Psychotropics:
Psychotropics:
Psychotropics:
Psychotropics:
Medication:
>Calcium Channel
Blockers
Hormones/chemo
Anticonvulsants:
therapeutics:
Proton Pump
Inhibitors:
Hypoglycemics:
Antihistamines:
abuse/treatment:
Beta Blockers:
>Cough
Medicines
Opiates:
Antibiotics/
Antifungals:
Anticonvulsants:
Antihistamines:
3101 Western Ave, Suite 100, Seattle, WA 98121 This is an illustrative guide to the cytochrome P450 contribution to drug interactions likely for medication pairs that are substrates, inhibitors or inducers of the same enzyme. More than one-half of patients also carry genetic variations in CYP 1A2, 2C9, 2C19, and 2D6 genes that can dramatically alter patient drug exposures, and for which DNA testing can be ordered. The GeneMedRx drug interaction software provides a more complete and automated tool for comprehensive medication management, with optional input of genetic variations, OTCs, foods, herbals, and other relevant patient factors to produce drug interaction reports based on the cumulative effect of all known drug metabolism variables. Obtain a fully functional 30-day free trial at www.GeneMedRx.com or call 1 877 431-4362. P450 DRUG-INTERACTIONS INHIBITORS TABLE (compiled by Jessica Oesterheld, M.D.)
Inhibitors (reduces or blocks the ability of the enzyme to metabolize the substrates)
clopidogrel
gemfibrozil
Plavix
atazanavir
ciprofloxacin
Reyataz
enoxacin
enoxacin
cinacalcet
clarithromycin
delavirdine
flutamide
fluvoxamine
ticlopidine
lomefloxacin
Ticlid
mexiletine
Mexitil
fluoxetine
norfloxacin
goldenseal
indinavir
sulfaphenazole
itraconazole
ketoconazole
nefazodone
propafenone
nelfinavir
ritonavir and
boosted PIs
paroxetine
saquinavir
telithromycin
quinidine/quinine
voriconazole
ritonavir {sertraline} terbinafine thioridazine ticlopidine P450 DRUG-INTERACTIONS INDUCERS TABLE (compiled by Jessica Oesterheld, M.D.)
Inducers (increases the ability of the enzyme to metabolize the substrates)
primidone rifampins St John’s Wort pioglitazone Actos topiramate at >200 mg/d 3101 Western Avenue, Suite 100, Seattle, WA 98121

Source: http://genelex.com/Druglist.pdf

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